Can head position and cooling boost brain recovery after cardiac arrest?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Master Platform Eligibility: * Adult patients aged 18 years or older * Return of spontaneous circulation after cardiac arrest * Persistent coma after return of spontaneous circulation (GCS motor score \<6) * Requirement for intensive care management Head Positioning Domain Eligibility: * Non-traumatic out-of-hospital or in-hospital cardiac arrest * Systolic blood pressure ≥80 mmHg or mean arterial pressure ≥65 mmHg (fluid resuscitation and vasopressor use permitted; transient hypotension recoverable within 20-30 minutes is acceptable) Temperature Control Domain Eligibility: * Initial non-shockable cardiac arrest rhythm * Systolic blood pressure ≥80 mmHg or mean arterial pressure ≥65 mmHg (fluid resuscitation and vasopressor use permitted; transient hypotension recoverable within 20-30 minutes is acceptable) * Ability to initiate temperature control therapy within 240 minutes after return of spontaneous circulation Exclusion Criteria: Master Platform Exclusion: * Refusal of intensive care management * Extracorporeal cardiopulmonary resuscitation (ECPR) * Pregnancy or possible pregnancy * Cardiac arrest due to intracranial hemorrhage, subarachnoid hemorrhage, cerebral infarction, acute aortic dissection, or terminal cancer (including suspected cases) * Severe chronic obstructive pulmonary disease requiring home oxygen therapy * Poor pre-arrest neurological function (CPC 3-4) or poor overall functional status (OPC 3-4) * Pre-existing do-not-attempt-resuscitation (DNAR) order * Expected early death * Inability to obtain consent from a legally acceptable representative or the participant * Enrollment judged inappropriate by the investigator Head Positioning Domain Exclusion: * Body temperature \<30°C on hospital arrival * Refusal of consent for participation in the head positioning domain * Enrollment judged inappropriate by the investigator * Patients using Impella® (a percutaneous mechanical circulatory support catheter) at the time of ICU admission * Patients using an intra-aortic balloon pump (IABP) at the time of ICU admission * Patients for whom feedback-controlled device-based temperature management or fever prevention is not being performed and is not planned at the time of ICU admission Temperature Control Domain Exclusion: * rCAST \<4.5 * rCAST ≥17.0 * Traumatic cardiac arrest * Body temperature \<30°C on hospital arrival * Refusal of consent for participation in the temperature control domain * Enrollment judged inappropriate by the investigator