A new protocol after heart attacks could slash risk of repeat events
NCT ID NCT07773272
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This trial tests whether starting a comprehensive, guideline-based treatment plan immediately after a heart attack can reduce the chance of another heart attack, stroke, or death. The plan targets key risk factors like high cholesterol, high blood pressure, and diabetes using a combination of medications. About 1,200 adults who had a heart attack and underwent a stent procedure will be enrolled. Half will receive this rapid protocol, while the other half gets standard care, and outcomes are compared over two years.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Rapid ESC-guideline-based secondary prevention protocol including lipid-lowering, antihypertensive, SGLT-2 inhibitors, and GLP-1 agonists
- What this could lead to
- If effective, this approach could become a standard protocol to prevent recurrent heart attacks and strokes, improving survival and quality of life.
- What could go wrong
- The trial is testing a protocol, not a single drug, so results may vary. It's uncertain whether the rapid approach will outperform standard care in reducing events.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 1,215 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Mar 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The study population consists of patients, hospitalised in Zuyderland, who underwent a percutaneous coronary intervention due to an acute coronary syndrome (unstable angina (UA), ST-elevation myocardial infarction (STEMI), or non ST-elevation myocardial infarction (non-STEMI)).
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age \> 18 years * Hospitalised with acute coronary syndrome * Underwent percutaneous coronary intervention Exclusion Criteria: * Acute coronary syndrome secondary to other diseases * Life expectancy \< 1 year based on the clinician's expertise
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Cardiology
RECRUITINGHeerlen, Limburg, 6419 PC, Netherlands
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