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Which antibiotic wins against MRSA in the blood? new trial aims to find out

NCT ID NCT06637332

Disease control Sponsor: Todd C. Lee MD MPH FIDSA Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 10, 2026 · Updated 4 times

Summary

This study compares two common antibiotics, daptomycin and vancomycin, to see which one works better for adults with MRSA bloodstream infections. About 300 participants will be randomly assigned to one of the two drugs. The goal is to find which treatment leads to fewer complications and better survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Nov 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

The participant must meet all inclusion and exclusion criteria for the SNAP Platform (NCT05137119) and also the following inclusion and exclusion criteria: Inclusion Criteria: * Methicillin-resistant S. aureus bacteremia Exclusion Criteria: * Severe allergy or non-severe rash to vancomycin or daptomycin * Suspected or confirmed MRSA pneumonia * Known vancomycin minimum inhibitory concentration (MIC) greater than or equal to 2mg/L or daptomycin MIC greater than or equal to 1mg/L

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Conditions

The condition(s) this trial relates to.

bacterial endocarditis methicillin-resistant staphylococcus aureus infectious disease staphylococcus aureus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

S. aureus bacteremia S. aureus bloodstream infection Staphylococcus aureus bacteremia Staphylococcus aureus endocarditis Staphylococcus aureus septicemia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    20 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Blacktown Hospital

    RECRUITING

    Blacktown, New South Wales, NSW 2148, Australia

  • Box Hill Hospital

    RECRUITING

    Box Hill, Victoria, 3128, Australia

  • Concord Repatriation and General Hospital

    RECRUITING

    Concord, New South Wales, 2139, Australia

  • Fiona Stanley Hospital

    RECRUITING

    Murdoch, Western Australia, 6150, Australia

  • Flinders Medical Centre

    RECRUITING

    Bedford Park, South Australia, 5042, Australia

  • Fraser Health Authority (Surrey Memorial Hospital)

    RECRUITING

    Surrey, British Columbia, V3V1Z2, Canada

  • Hamilton Health Sciences (Hamilton General Hospital and Juravinski Hospital)

    RECRUITING

    Hamilton, Ontario, L8L 2X2, Canada

  • Jewish General Hospital

    RECRUITING

    Montreal, Quebec, H3T 1E2, Canada

  • John Hunter Hospital

    RECRUITING

    Newcastle, New South Wales, 2305, Australia

  • McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)

    RECRUITING

    Montreal, Quebec, H4A3S1, Canada

  • Middlemore Hospital

    RECRUITING

    Otahuhu, Auckland, New Zealand

  • Monash Health - Casey Hospital

    RECRUITING

    Berwick, Victoria, 3806, Australia

  • Monash Medical Campus (Monash Medical Centre + Jesse McPherson Private Hospital)

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • Newfoundland Health Services (Health Sciences Centre and St. Clare's Mercy Hospital)

    RECRUITING

    St. John's, Newfoundland and Labrador, Canada

  • Royal Brisbane and Women's Hospital

    RECRUITING

    Herston, Queensland, 4029, Australia

  • Royal Melbourne Hospital

    RECRUITING

    Parkville, Victoria, 3050, Australia

  • Royal Perth Hospital

    RECRUITING

    Perth, Western Australia, 6000, Australia

  • Sunnybrook Health Sciences Centre

    RECRUITING

    Toronto, Ontario, M4N 3M5, Canada

  • University of Alberta Hospital

    RECRUITING

    Edmonton, Alberta, Canada

  • Westmead Hospital

    RECRUITING

    Westmead, New South Wales, 2145, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.