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Heart infection treatment: could less be more?

NCT ID NCT07253688

First seen Jan 08, 2026 · Last updated May 21, 2026 · Updated 28 times

Summary

This study looks at whether not giving the antibiotic rifampin is as safe and effective as giving it for people with a serious heart valve infection caused by S. aureus bacteria. About 330 adults with infected prosthetic heart valves will be randomly assigned to receive or skip rifampin alongside standard care. The goal is to see if avoiding rifampin reduces side effects without increasing complications like death, need for heart surgery, or new infections.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)

    RECRUITING

    Montreal, Quebec, H4A4S1, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact

Conditions

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