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Double trouble for staph: could two antibiotics beat one?

NCT ID NCT07376889

Disease control Sponsor: Intermountain Health Care, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 26, 2026 · Updated 2 times

Summary

This study looks at whether using a combination of antibiotics is more effective than a single antibiotic for treating serious staph infections in the blood. About 2,096 adults with either methicillin-sensitive or methicillin-resistant staph will be randomly assigned to one group or the other. The main goal is to see which approach leads to better overall outcomes, including fewer complications and deaths within 30 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
combination of antibiotics (beta-lactam plus vancomycin or daptomycin)
What this could lead to
If it works, this could show that using two antibiotics together is more effective than one for treating serious staph bloodstream infections, potentially reducing complications and deaths.
What could go wrong
This is a large phase 4 trial, but results may not apply to all patients. Combination therapy could increase side effects or antibiotic resistance without improving outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 2,096 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * Alive and admitted to an Intermountain Health (IH) hospital acute care unit at enrollment * Initial positive blood culture with either methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-susceptible Staphylococcus aureus (MSSA), collected: 1. on or during the index admission to an IH hospital, or 2. in an ambulatory setting (laboratory, clinic or emergency department) within 48 hours of the index admission, or 3. at a non-IH network hospital within 24 hours of subsequent transfer to an IH hospital Exclusion Criteria: * Patient requests that patient health data not be included in the analysis

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Conditions

The condition(s) this trial relates to.

staphylococcus aureus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Staphylococcus aureus bacteremia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    13 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Good Samaritan Hospital

    NOT_YET_RECRUITING

    Lafayette, Colorado, 80026, United States

  • Holy Rosary Hospital

    NOT_YET_RECRUITING

    Miles City, Montana, 59301, United States

  • Intermountain Medical Center

    RECRUITING

    Murray, Utah, 84107, United States

  • LDS Hospital

    NOT_YET_RECRUITING

    Salt Lake City, Utah, 84143, United States

  • Lutheran Medical Center

    NOT_YET_RECRUITING

    Wheat Ridge, Colorado, 80401, United States

  • McKay-Dee Hospital

    NOT_YET_RECRUITING

    Ogden, Utah, 84403, United States

  • Platte Valley Hospital

    NOT_YET_RECRUITING

    Brighton, Colorado, 80601, United States

  • Saint Joseph Hospital

    NOT_YET_RECRUITING

    Denver, Colorado, 80218, United States

  • St. George Regional Hospital

    NOT_YET_RECRUITING

    St. George, Utah, 84790, United States

  • St. James Hospital

    NOT_YET_RECRUITING

    Butte, Montana, 59701, United States

  • St. Mary's Regional Hospital

    NOT_YET_RECRUITING

    Grand Junction, Colorado, 81501, United States

  • St. Vincent Regional Hospital

    NOT_YET_RECRUITING

    Billings, Montana, 59101, United States

  • Utah Valley Hospital

    NOT_YET_RECRUITING

    Provo, Utah, 84604, United States

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