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Supplements and exercise: a new hope for frail seniors?

NCT ID NCT07275996

Disease control Sponsor: Universidad de Burgos Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding creatine and HMB supplements to a supervised exercise program can improve physical function, muscle mass, thinking skills, and quality of life in frail older adults living in nursing homes. Fifty people aged 65 and older are taking part, receiving either placebo, creatine, HMB, or both, plus exercise, for 12 weeks. The goal is to find a practical way to help seniors stay stronger and more independent.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
creatine monohydrate and β-hydroxy-β-methylbutyrate (HMB) dietary supplements
What this could lead to
If it works, this could point toward a simple, affordable supplement-plus-exercise strategy to help frail older adults maintain strength, mobility, and independence.
What could go wrong
This is a small, early-stage trial with only 50 participants, so results may not apply to all older adults. Supplements may have no added benefit over exercise alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Mar 2026

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Institutionalized older adults (≥65 years) residing in the Fuentes Blancas Nursing Home (Diputación de Burgos). * Clinical diagnosis of frailty or sarcopenia according to validated criteria (e.g., Fried phenotype, SPPB ≤ 9, or low ALMI by DEXA). * Ability to participate in an exercise program as assessed by the medical staff. * Written informed consent provided by the participant or, if cognitively impaired, by a legally authorized representative. Exclusion Criteria: * Severe renal insufficiency (eGFR \< 30 mL/min/1.73m²) or liver failure. * Advanced heart failure (NYHA class III-IV) or unstable cardiovascular disease. * Active cancer or other severe medical conditions that contraindicate participation. * Severe cognitive impairment (MMSE \< 10) precluding adherence to the program without caregiver support. * Known allergy or intolerance to creatine, HMB, or inulin. * Participation in another clinical trial within the past 3 months. * Any condition that, in the opinion of the medical team, may compromise safety or adherence to the intervention.

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Conditions

The condition(s) this trial relates to.

Frailty Inflammation nutritional deficiency disease Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Frailty Malnutrition elderly Sarcopenia

Contacts and locations

Locations

  • Residencia de Mayores Fuentes Blancas (Diputación Provincial de Burgos)

    Burgos, Castille and León, 09002, Spain

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