University Of Maryland, Baltimore

This large phase 3 trial is testing a typhoid conjugate vaccine (Vi-TCV) in 30,000 healthy children aged 9 months to 12 years in Malawi. Half get the typhoid vaccine, half get a meningitis vaccine for comparison. The goal is to see if the typhoid vaccine prevents blood-confirmed …

This study tests a telehealth platform called Medherent for people with serious mental illness living in the community. The platform helps with medication reminders, health monitoring, and virtual doctor visits. Researchers will track whether it reduces hospitalizations and impro…

This study tests a mobile app called HealthMPowerment (HMP) designed to help young men who have sex with men (ages 15-24) start HIV prevention (PrEP) or stay on treatment. 1,500 participants will either get the app right away or after a delay. Researchers will check if the app im…

This study tests a program to help people living with HIV in Botswana stop smoking. It combines counseling with a medication called varenicline. The goal is to see if this approach helps them quit and improves their health. The study involves 750 participants who are daily smoker…

This study tests whether having more postpartum visits with an obstetric provider or nurse helps mothers with high blood pressure or diabetes manage their health during the first year after giving birth. 100 mothers with Medicaid insurance are taking part. The goal is to see if t…

This early-phase study tests a new type of CAR T-cell therapy that targets three different markers on cancer cells (CD19, CD20, and CD22) to treat people with B-cell lymphomas that have come back or not responded to standard treatments. About 15 adults will receive these speciall…

This early-phase trial tests a new drug called CRD3874-SI that activates the STING protein to help the immune system fight cancer cells. It is for adults with acute myeloid leukemia that has come back or not responded to standard treatments. The main goals are to check safety and…

This early-phase trial tests whether giving higher doses of radiation to the prostate in fewer sessions (while also treating pelvic lymph nodes) is safe for men with intermediate- to high-risk prostate cancer. The study enrolls 18 adults and uses proton beam therapy delivered fou…

This study tests whether adding bavituximab to pembrolizumab can help shrink tumors in people with advanced head and neck cancer that has continued to grow despite prior immunotherapy. About 7 participants will receive both drugs intravenously. The main goal is to see how many pa…

This study tests a digital health system that reminds people with inflammatory bowel disease (IBD) to take their medication and lets them report symptoms. About 123 adults starting a new oral or injectable treatment will use the system or get standard care for 12 months. The goal…

This study looks at three different ways to treat deep cavities in children's baby molars without pulling the tooth. The treatments are two types of pulpotomy (removing part of the tooth nerve and placing a material on it) and an indirect pulp cap (leaving some decay and sealing …

This study looks at men whose prostate cancer has come back in a few spots (oligometastatic) and who have certain gene mutations. It compares standard care (hormone therapy plus radiation) against the same treatment plus a 6-month course of two drugs (niraparib and abiraterone wi…

This early-stage trial tests the safety of combining precise radiation (SBRT) with immunotherapy (durvalumab) and two chemotherapy drugs (platinum and etoposide) for people with extensive-stage small cell lung cancer that has stopped responding to platinum chemo. The study aims t…

This study is testing whether a wearable heart monitor (Zio patch) worn for two weeks can detect undiagnosed atrial fibrillation in women aged 70 and older. Atrial fibrillation is a common heart rhythm problem that raises stroke risk, especially in older women. The goal is to see…

This study tests whether giving the antibiotic azithromycin to pregnant women and their babies during routine care can prevent stillbirths and infant deaths in Mali, a country with very high infant mortality. Over 99,000 participants are involved in this large, placebo-controlled…

This study tests a personalized support program (C4) to help Black men who have sex with men take their HIV prevention medication (PrEP) consistently. About 350 men will either get the program or standard care. The program addresses personal needs like mental health and housing t…

This study explores whether immersive virtual reality can help reduce chronic pain in people with temporomandibular disorder (TMD). About 259 participants will experience active VR, a sham VR, or no VR while their pain tolerance is measured. The goal is to understand how VR works…

This study tests whether a ketogenic diet—low in carbs, high in fat—can reduce symptoms in people with schizophrenia or schizoaffective disorder. Fifty adults will be randomly assigned to either the ketogenic diet or a regular diet for several weeks. Researchers will measure chan…

This study is testing whether a moderate exercise program can improve strength, balance, and endurance in children with sickle cell disease. Twenty children ages 6 to 17 will take part in strengthening and endurance exercises. Researchers will measure changes in muscle strength, …

This study tests if chewing sugar-free gum during colonoscopy bowel preparation can reduce side effects like nausea and bloating. About 100 adults scheduled for a colonoscopy will either chew gum or not during their prep. The goal is to see if this simple trick helps people finis…

This early-phase study tests whether MRI-guided focused ultrasound can safely reduce severe facial pain in people with trigeminal neuralgia that hasn't responded to medication. Ten adults aged 21-75 with chronic pain for over 6 months will receive a precise ultrasound treatment t…

This observational study at the University of Maryland will follow 40 pregnant women to see how their physical activity levels influence the development and function of the placenta. Participants will provide biological samples and health information during pregnancy and at deliv…

This early-stage study planned to test whether a drug called glucagon-like peptide-1 (GLP-1) could protect blood vessels from damage caused by repeated low blood sugar in people with type 1 diabetes. The researchers aimed to enroll 40 adults aged 18–50. However, the study was wit…

This study looks at whether patients with surgically treated leg, pelvis, or hip socket fractures can safely start walking right away instead of waiting 6-12 weeks. About 100 adults will be randomly assigned to immediate weightbearing or delayed weightbearing. The goal is to see …

This study looks at how low blood sugar (hypoglycemia) affects blood vessel function in people with type 2 diabetes and healthy adults. Researchers want to learn if a natural gut hormone called GLP-1 can change these effects. The study involves 28 participants and measures change…

This study looks at how accurately small tooth-colored bumps (attachments) used with Invisalign aligners match their planned shapes and sizes. Researchers are comparing two designs—optimized and conventional—in 30 adults starting Invisalign treatment. Digital scans taken right af…

This study tests whether a drug can help red blood cells work better in low-oxygen (hypoxia) and cold (hypothermia) conditions, which are common in high-altitude or military environments. Researchers will measure how the drug affects red blood cell energy and antioxidant defenses…

This study teaches clinicians and researchers how to start and follow a medical ketogenic diet to improve mental health. Participants first attend a mastery class, then optionally try the diet themselves for 4 weeks with group support. The goal is to help professionals feel confi…

This study was designed to see if a new method for fitting breast pump flanges (the part that goes over the breast) helps parents of babies in the NICU produce more milk and feel more satisfied with pumping. Researchers planned to compare the new fitting method to standard instru…

This study looks at whether modern medicines (like statins and newer blood thinners) can keep the one-year stroke rate below 5% in people with narrowed neck arteries who have already had a minor stroke or warning signs. About 114 participants are being followed to see how well th…

This study looks at how the typhoid vaccine changes immune cells and bacteria in the gut. About 87 adults scheduled for routine colonoscopies will either get the vaccine before or after the procedure, or not at all. Researchers will collect tissue, blood, saliva, and stool sample…

This study looks at whether a person's genes can predict how their body responds to canagliflozin, a drug used for type 2 diabetes. About 700 healthy Amish adults will take the drug for five days, and researchers will measure changes in urine sugar and other markers. The goal is …

This study aimed to compare two devices—ultrasound and a near-infrared device called Vein Viewer—to see which helps emergency room staff start IVs faster in patients with difficult veins. The goal was to reduce delays in care. However, the study was withdrawn before enrolling any…

This study looks at two common surgeries for a certain type of hip fracture in people aged 60 and older: hip replacement or using screws/pins to hold the bone together. The main goal is to see if a larger study is possible by checking how many people join, how well the treatments…

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help older adults on hormone therapy for prostate or breast cancer stay stronger and more resilient. Researchers will track 30 people over 55 to see if this eating pattern is prac…

This study looks at whether a single dose of diclofenac, a common pain reliever, can change a specific brain chemical in people with alcohol use disorder. Twelve adults with mild to severe alcohol use disorder will receive either diclofenac or a placebo in a double-blind fashion.…

This study aimed to find the best length of time for patients to take antibiotics after surgery for an infected joint replacement. It planned to compare different antibiotic durations to see which works best to prevent the infection from coming back and to avoid antibiotic resist…