University Of Maryland, Baltimore

This study tests whether adding a drug called bavituximab to the immunotherapy pembrolizumab can help shrink tumors or slow cancer growth in people with advanced head and neck cancer that has gotten worse after standard treatments. The trial enrolled 7 adults whose cancer had pro…

This study tests whether suvorexant, a sleep aid, can lower the desire for drugs in people with opioid use disorder. Researchers will measure how much drug participants choose at different prices. The trial is in early stages and is currently on hold.

This early-stage trial is testing the safety of combining adaptive radiation with immunotherapy (durvalumab) and standard chemotherapy for people with extensive-stage small cell lung cancer that has stopped responding to platinum chemotherapy. The study aims to see how many patie…

This study looks at three different ways to treat deep cavities in children's baby molars without pulling the tooth. The treatments are two types of pulpotomy (removing part of the tooth nerve) and an indirect pulp cap (leaving some decay and sealing it). The goal is to see which…

This study tests a program to help 750 people with HIV in Botswana stop smoking. The program combines counseling and a medication called varenicline. Quitting smoking can reduce the harmful effects of HIV and prevent early death. The study also looks at how to make this help avai…

This large study in Mali, West Africa, tests whether giving the antibiotic azithromycin to pregnant women and their babies can prevent stillbirths and infant deaths. Over 99,000 participants are involved. The goal is to find a simple, low-cost way to save lives in an area with ve…

This study looks at whether a moderate exercise program can help children with sickle cell disease improve their strength, balance, and walking ability. Twenty children aged 6 to 17 will take part in a targeted training program. The goal is to see if the program is feasible and h…

This study looks at whether chewing sugar-free gum during colonoscopy bowel prep can help people feel less nausea, bloating, and discomfort. About 100 adults aged 45-75 scheduled for a colonoscopy will be randomly assigned to chew gum or not. The goal is to see if this simple, lo…

This study tests whether a ketogenic diet (low-carb, high-fat) can reduce symptoms in people with schizophrenia or schizoaffective disorder. Fifty adults aged 18-64 will be randomly assigned to either the ketogenic diet or a control diet for several weeks. Researchers will measur…

This early study tests whether MRI-guided focused ultrasound can safely treat severe facial pain (trigeminal neuralgia) that hasn't responded to medication. Ten adults with chronic pain will receive a precise ultrasound beam to a small brain area involved in pain. The goal is to …

This study looks at how immersive virtual reality affects chronic pain, especially in people with temporomandibular disorder (TMD). Researchers want to see if VR works differently than a placebo to reduce pain. About 259 adults aged 18-88 with TMD for at least 3 months will take …

This early-stage study looks at whether a single dose of diclofenac, a common pain reliever, can alter a specific brain chemical in people with alcohol use disorder. Twelve adults with mild to severe alcohol use disorder will receive either diclofenac or a placebo in a double-bli…

This study looks at how being physically active during pregnancy affects the placenta, the organ that supports the baby's growth. Researchers will collect samples and health information from 40 pregnant women to see if regular activity improves placental function. The goal is to …

This study looks at small tooth-colored bumps called attachments that help Invisalign aligners move teeth. Researchers want to see if newer 'optimized' attachments are placed more accurately and last longer than traditional ones. About 30 adults starting Invisalign will have thei…

This study looks at how the typhoid vaccine changes the immune system and bacteria in the gut. About 87 adults who are already having a colonoscopy will either get the vaccine before or after the procedure, or not get it at all. Researchers will collect tissue, blood, saliva, and…

This pilot study looks at two common surgeries for a certain type of hip fracture in people 60 and older: hip replacement or using screws/pins to hold the bone in place. The main goal is not to decide which is better, but to see if a larger study is possible by checking how many …

This study teaches healthcare workers and researchers how to use a medical ketogenic diet to improve mental health. Participants first attend an education class, then have the option to follow the diet themselves for 4 weeks with group support. The goal is to help professionals f…

This study checks for atrial fibrillation (an irregular heartbeat) in women aged 70 and older who have never been diagnosed with it. Researchers want to see how common it is and whether finding it leads to more use of blood thinners to prevent strokes. Participants wear a heart m…

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help older adults on hormone therapy for prostate or breast cancer stay stronger and more resilient. Researchers will measure frailty and how well the body handles stress. The goa…

This study looks at how a person's genes might influence their body's response to canagliflozin, a drug used for type 2 diabetes. Healthy volunteers of Amish descent will take the drug for five days, and researchers will measure how much sugar is passed in urine and check other h…