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Virtual reality may offer Drug-Free pain relief for jaw disorder sufferers

NCT ID NCT04851301

Symptom relief Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study explores whether immersive virtual reality can help reduce chronic pain in people with temporomandibular disorder (TMD). About 259 participants will experience active VR, a sham VR, or no VR while their pain tolerance is measured. The goal is to understand how VR works in the brain compared to placebo, potentially leading to new non-drug pain treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
virtual reality
What this could lead to
If it works, this could point toward a non-drug, low-risk way to manage chronic pain using virtual reality.
What could go wrong
This is an early-phase study (Phase 1/2) with a small sample, so results may not apply broadly. The sham VR group helps test if effects are just placebo, and naloxone is used to explore pain mechanisms, not as a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

259 people

The number who actually took part.

Started

Nov 2021

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 88 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age (18-88 years) * English speaker (written and spoken) * Temporal Mandibular Disorder (TMD) for at least 3 months Exclusion Criteria: * Present or past degenerative neuromuscular disease * Cardiovascular, neurological diseases, pulmonary abnormalities, kidney disease, liver disease, history of cancer within past 3 years * Cervical pain other than TMD related (e.g. stenosis, radiculopathy) * Any personal (or family first degree) history of mania, schizophrenia, or other psychoses * Severe psychiatric condition (e.g., schizophrenia, bipolar disorders, autism) leading to hospitalization within the last 3 years. * Use of antidepressants, ADHD medication, non-over-the-counter painkillers, methadone, benzodiazepines, barbiturates, and/or narcotics during the past 3 months * Lifetime alcohol/drug dependence or alcohol/drug abuse in the past 3 months * Pregnancy or breastfeeding * Color-blindness * Pain in jaw or temple in last 3 months due to toothache or infection * Any facial trauma that has occurred in the last 6 weeks * History of severe facial trauma in the last 3 months * Impaired or uncorrected hearing * Conditions that would interfere with the VR mask placement (e.g. trauma, burn, infection) * Known history of severe motion sickness * High blood pressure or symptomatic low blood pressure * History of fainting * History of angioedema * Failed drug test (testing for opiates, cocaine, methamphetamines, amphetamines, and THC)

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Conditions

The condition(s) this trial relates to.

Pain temporomandibular joint disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain Placebo Temporomandibular disorder Virtual reality

Contacts and locations

Locations

  • Luana Colloca

    Baltimore, Maryland, 21201-1512, United States

More trials for these conditions

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