University Of Maryland, Baltimore

This study tests an experimental drug called Imdusiran (AB-729) in 10 adults with chronic hepatitis B. Participants receive four injections over 24 weeks and undergo two liver biopsies to see how well the drug works inside the liver. The goal is to understand how the drug affects…

This study is for people with HPV-related throat cancer. It tests whether a blood test (ctDNA) can identify patients who are at very low risk of their cancer returning after surgery. If the test is negative, they may not need radiation, which has serious side effects. The goal is…

This study tests two methods for managing severe open fractures of the shin bone: an antibiotic bead pouch or a vacuum-sealed wound dressing. About 312 adults with these serious injuries will be randomly assigned to one treatment. Researchers will check healing, infections, and n…

This study tests whether trained peers can help Black individuals living with or at high risk for HIV stay on track with long-acting injectable HIV medication and reduce substance use. About 186 participants will receive either peer-led support or standard care. The goal is to se…

This study tests a two-step treatment for people whose brain tumors (gliomas) have returned after standard care. First, a laser is used to heat and destroy tumor tissue, followed by a short course of targeted radiation. The goal is to see if this approach is safe and can help con…

This study is testing a single, focused dose of radiation given before surgery to remove early-stage breast cancer. The radiation is delivered using a special machine called the GammaPod, which targets the tumor precisely and spares healthy tissue. The goal is to find a safe and …

This early-phase study tests whether adding deep heat therapy and a special type of radiation to standard chemoimmunotherapy is safe and doable for people with advanced bile duct cancer that cannot be removed by surgery. About 15 adults will receive the standard drugs gemcitabine…

This early-phase study tests a special MRI that uses a natural sugar-like substance (pyruvate) to see how tumors use energy. Cancer cells often consume more sugar than normal cells, and this scan aims to make that visible. About 25 adults with known tumors will be scanned to see …

This study tests a special MRI scan that uses a natural substance (pyruvate) to see if it can better diagnose brain tumors called gliomas. About 5 adults with suspected or known gliomas will get this extra scan before their planned surgery. The goal is to see if the new MRI is sa…

This study tests a personalized training program to help older adults at high risk of falling. About 40 people aged 60 to 85 who have fallen before will receive exercises tailored to their specific balance problems. The goal is to reduce falls and improve safety at home.

This study looks at whether giving the drug daratumumab as a shot in the thigh works as well as the usual shot in the belly for people with plasma cell disorders like multiple myeloma. Daratumumab helps the immune system kill abnormal plasma cells. The goal is to find a less pain…

This study tests whether a prebiotic (a type of fiber that feeds good gut bacteria) can reduce inflammation and improve thinking and memory in people with schizophrenia or schizoaffective disorder. Researchers will enroll 60 adults who are stable on antipsychotic medication. The …

This study tests a home-based robot that stretches and moves the ankle, combined with mild electrical stimulation to activate leg muscles, for people who had a stroke at least 6 months ago. The goal is to improve walking, range of motion, and muscle strength. 60 participants will…

This early-phase study tests whether diclofenac, an FDA-approved pain reliever, can help people with alcohol use disorder by changing brain chemistry. Researchers will give 24 adults either a placebo or one of three doses of diclofenac and measure its effects on craving, mood, an…

This study tests whether using virtual reality (VR) alongside standard care can reduce pain for adults with sickle cell disease who are in the emergency department for a painful crisis. About 30 participants will be split into three groups to compare pain scores and comfort. The …

This early-stage study tests whether MRI-guided focused ultrasound can safely treat task-specific focal hand dystonia, a condition causing involuntary cramping during activities like writing or playing an instrument. Ten adults who haven't improved with standard treatments will r…

This study looks at whether it's safe for people having hip or knee replacement to go home the same day without a final physical therapy (PT) check. Instead, patients get PT training before surgery and walk with a nurse after. The goal is to see if this approach leads to more fal…

This study tests two methods of notifying family members about their risk for inherited heart conditions like Long QT Syndrome and Familial Hypercholesterolemia. About 200 adults who carry a specific gene variant will be randomly assigned to either contact their relatives themsel…

This study tests a program to help nursing home staff better assess and manage pain in residents with dementia. The program includes staff education, mentoring, and regular check-ins over 12 months. Researchers will compare this program to standard education alone in 12 communiti…

This study looks at eye changes in cancer patients who have dry eye disease from graft-versus-host disease (a complication of bone marrow transplants). Researchers will collect eye samples from 150 adults to find risk factors, markers, and possible treatment targets. The goal is …

This study looks at leftover tissue from people with a rare, life-threatening windpipe narrowing caused by scarring. Researchers will analyze the tissue's RNA to understand what makes the scarring happen. The goal is to find new ways to treat or prevent this condition. About 10 a…

This study looks at whether measuring blood flow in the back of the eye can help find early signs of glaucoma, a leading cause of blindness. Researchers will compare blood flow in people with early glaucoma and healthy volunteers. The goal is to develop a new, non-invasive way to…

This study is creating a registry and biobank for 350 adults with autosomal dominant polycystic kidney disease (ADPKD). Researchers will collect medical images, blood, urine, and DNA samples, and track quality of life. The goal is to build a resource that helps scientists design …

This pilot study tests whether a type of brain stimulation called repetitive TMS can increase natural inhibition in the brain's motor area. Researchers will measure changes in brain activity and thinking in 34 people with schizophrenia. The goal is to understand how brain inhibit…

This study looks at how different levels of low blood sugar (hypoglycemia) affect blood vessels in healthy adults. Researchers will measure changes in blood vessel function before and after controlled low blood sugar. The goal is to understand the body's response, not to treat a …

This study looks at whether learning to play a pretend musical instrument can help repair brain wiring in people with schizophrenia. The researchers will use brain scans to see if training changes the brain's white matter, which helps different areas communicate quickly. Poor whi…

This study tests whether an attachment-based parenting program (ABC) can improve health outcomes in 260 low-income Latino children starting at 9 months old. Researchers will track common illnesses, sleep, weight, and inflammation over 15 months, comparing the program to a reading…

This study explores whether virtual reality exercise can help older adults (55+) stay physically active and maintain muscle function during a hospital stay. Researchers will enroll 140 participants to test if this approach is acceptable and effective. The goal is to prevent the c…

This pilot study uses Brillouin microscopy, a non-contact imaging method, to measure how stiff the cornea is in people with glaucoma. Researchers will compare corneal stiffness between patients with high-tension glaucoma, normal-tension glaucoma, and healthy volunteers. The goal …