Typhoid vaccine study seeks immune clues

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years and older * Good general health as determined by a screening evaluation within 28 days before blood donation * Informed, written consent Exclusion Criteria: * History of any of the following medical illnesses: * Diabetes * Cancer in past 5 years (except for basal cell carcinoma of the skin and cervical carcinoma in situ) * Heart disease (Hospitalization for a heart attack, coronary artery bypass graft, arrhythmia, or syncope, within past 5 years. Current symptoms of heart disease - dyspnea, angina, orthopnea) * Recurrent infections (more than 3 hospitalizations for invasive bacterial infections such as pneumonia or meningitis) * Current drug or alcohol abuse * Active ulcer disease or ongoing intestinal condition * Treatment for anemia in last 6 months * Currently being treated with anti-malarial drugs * Any of the following laboratory abnormalities detected during medical screening: * WBC \<0.81 x LLN or \> 1.09 x ULN * Hemoglobin \<0.91 x LLN or \>1.18 x ULN (women) or \<0.92 x LLN or \>1.18 x ULN (men) * Platelet count \<0.8 x LLN or \> 1.2 x ULN * (For leukopheresis or blood unit donations, the following lab values are exclusionary: * WBC \<3.5 or \>11 x 103/mm3; * Hemoglobin \<12.5 or \>18 g/dl * Platelet count \<150 or \>500 x 103/mm3) * SGOT or SGPT \>1.5 times normal * Positive serology for hepatitis C or HIV antibody or hepatitis B surface antigen * Positive serology for hepatitis B core antibody * Poor peripheral venous access for blood donation * Positive RPR * Other condition that in the opinion of the investigator would jeopardize the safety or rights of a volunteer participating in the trial or interfere with the scientific integrity of study. * Positive urine pregnancy test (HCG) on day of vaccination. Prior to each blood donation -females with menstrual history consistent with pregnancy. Pregnant women will not be enrolled, because immunological changes that occur during pregnancy may interfere with laboratory assays.