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Old stroke data gets a modern check: do newer drugs lower risk?

NCT ID NCT05300737

Knowledge-focused Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether modern medicines (like statins and newer blood thinners) can keep the one-year stroke rate below 5% in people with narrowed neck arteries who have already had a minor stroke or warning signs. About 114 participants are being followed to see how well these drugs work alone, without surgery. The goal is to update knowledge from 30-year-old studies that didn't have today's treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 114 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with 50-99% symptomatic carotid stenosis and low risk clinical or radiologic features

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥40 years plus stroke or TIA ipsilateral to 50-99% ICA stenosis In addition, patients must have at least one clinical or radiologic marker of reduced stroke risk Clinical Reduced Stroke RISK: 1. Retinal ischemia only (amaurosis fugax, branch retinal artery occlusion (BRAO), central retinal artery occlusion (CRAO) 2. Female sex 3. Most recent stroke or TIA \>1 week ago Radiologic Reduced Stroke RISK: 1. Transcranial Doppler (TCD) study demonstrating lack of microembolic signals 2. Cross-sectional MRI plaque imaging demonstrating absence of intraplaque hemorrhage 3. For patients with TIA: brain MRI shows no DWI lesion Exclusion Criteria: Atrial fibrillation or other high-risk sources of cardiac embolism unless it is device detected AF only or duration \<6 minutes Alcohol and substance abuse within the prior 24 months Clinically significant bleeding diathesis (platelet count \<100K, prothrombin time \>14 seconds) Clear indication for therapeutic anticoagulation (for example, DVT or pulmonary embolism within past 3 months) Left ventricular ejection fraction \<20% Known allergy or intolerance to aspirin or clopidogrel Life expectancy less than 12 months Moderate/severe dementia (Mini-mental or MOCA score \<22 Modified Rankin score of \>4 Nonatherosclerotic cause of carotid stenosis Most recent symptomatic event \>180 days from the time of enrollment \-

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Conditions

The condition(s) this trial relates to.

carotid stenosis ischemic stroke transient ischemic attack

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid stenosis Ischemic stroke Transient ischemic attack

Contacts and locations

Locations

  • Baylor Medicine

    Houston, Texas, 77030, United States

  • Baystate Medical Center

    Springfield, Massachusetts, 01199, United States

  • CHUM

    Montreal, Quebec, H2X 0C1, Canada

  • Calgary Health Sciences Center

    Calgary, Alberta, Canada

  • Emory University Hospital

    Atlanta, Georgia, 30322, United States

  • Hartford Hospital

    Hartford, Connecticut, 06102, United States

  • Northern Ontario School of Medicine

    Greater Sudbury, Ontario, Canada

  • Northwestern Memorial Hospital

    Chicago, Illinois, 60611, United States

  • Rhode Island Hospital

    Providence, Rhode Island, 02903, United States

  • Rush Medical Center

    Chicago, Illinois, 60612, United States

  • University of Alberta

    Edmonton, Alberta, Canada

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Manitoba

    Winnipeg, MN, Canada

  • University of Maryland Medical Center

    Baltimore, Maryland, 21201, United States

  • University of Massachusetts Medical Center

    Worcester, Massachusetts, 01655, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • Vancouver General Hospital

    Vancouver, British Columbia, Canada

  • Western University/London Health Sciences Center

    London, Ontario, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.