Could a High-Fat, Low-Carb diet ease schizophrenia?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18- 64 years 2. Diagnostic and Statistical Manual (DSM-IV/DSM 5) diagnosis of schizophrenia or schizoaffective disorder 3. Antipsychotic regimen with no dose change in last 14 days 4. Minimum score of 45 on BPRS 5. Body mass index \> 18.5 6. Ability to consent determined by a score of 10 or greater on the Evaluation to Sign Consent. Exclusion Criteria: 1. Pregnant or lactating females 2. Type I diabetes or insulin dependent Type II diabetes 3. Current diagnosis of DSM 5 eating disorder 4. Heart failure 5. corrected QT interval (QTc) prolongation greater than or equal to 500ms 6. Significant kidney disease Indicators for possible acute kidney injury (AKI) or moderate chronic kidney disease (CKD) based on some factors below. Each is not used individually but a clinician will determine based on the following: * Creatinine \> 1.3mg/dL * Glomerular Filtration Rate (GFR) \< 60 mL/min/1.73 m2 * Renal tubular disorders * History of kidney transplantation 7. Significant liver disease. Indicators for possible acute or chronic liver disease. Each is not used individually but a clinician will determine based on the following: * Prolonged International Normalized Ratio (INR) greater than or equal to 1.5, elevated bilirubin and aminotransferases (3x normal upper limit) and/or Complete Blood Count (CBC) abnormalities (thrombocytopenia, anemia) * Physical examination abnormalities (jaundice, icteric sclera, asterixis) * Alcohol use disorder (AUD) based on DSM 5 criteria for moderate AUD * History of liver disease (cirrhosis, Wilson disease, Gilbert disease, chronic hepatitis, autoimmune hepatitis, primary biliary cirrhosis (PBC), primary Sclerosing Cholangitis (PSC) alpha-1 antitrypsin deficiency, hereditary hemochromatosis, Budd-Chiari syndrome) * History of liver transplantation 8. Porphyria 9. Genetic disorders that affect fat metabolism (Gaucher disease, Tay-Sachs disease, medium-chain acyl-CoA dehydrogenase deficiency (MCADD) 10. Carnitine deficiency syndromes (primary carnitine deficiency, carnitine palmitoyltransferase deficiency, carnitine translocase deficiency) 11. Pyruvate kinase deficiency 12. Gastroparesis 13. Refusal to eat intervention diet, food allergies or restrictions that the kitchen cannot accommodate, and/or dietary noncompliance with dietary energy needs