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Triple threat: new CAR t-cells take on Hard-to-Treat lymphomas

NCT ID NCT07168486

First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 34 times

Summary

This early-phase study tests a new type of CAR T-cell therapy that targets three different markers on cancer cells (CD19, CD20, and CD22) to treat people with B-cell lymphomas that have come back or not responded to standard treatments. About 15 adults will receive these specially engineered immune cells to see if they are safe and effective. The goal is to improve cancer control and reduce the chance of relapse.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • University of Maryland, Baltimore

    Baltimore, Maryland, 21201, United States

Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia B-cell neoplasm Burkitt lymphoma diffuse large B-cell lymphoma follicular lymphoma Lymphoma, B-Cell, Marginal Zone mantle cell lymphoma marginal zone lymphoma primary mediastinal large B-cell lymphoma Recurrence Richter transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.