Could a gut hormone protect your blood vessels during low blood sugar?
NCT ID NCT01858896
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how low blood sugar (hypoglycemia) affects blood vessel function in people with type 2 diabetes and healthy adults. Researchers want to learn if a natural gut hormone called GLP-1 can change these effects. The study involves 28 participants and measures changes in blood vessel health during controlled low blood sugar episodes.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
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About 28 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2013
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 14 (7 males, 7 females) healthy controls age 30-60 yr. * 14 (7 males, 7 females) people with type 2 DM age 30-60 yr. * For type 2 DM: HbA1c 6-10.0% * No significant diabetic tissue complications (i.e. history of retinopathy, neuropathy, stasis ulcers, etc.) * Body mass index \>25kg • m-2 Exclusion Criteria: \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Maryland, Baltimore
Baltimore, Maryland, 21201, United States
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Other studies related to the condition(s) this trial covers.
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