Can alcohol abuse ruin your sense of taste and smell? new study investigates

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: To be eligible to participate in this study, an individual must meet all the following criteria: * Individuals between 18 to 65 years of age. Although the age range of participants recruited in the NIAAA Natural History protocol is between 18-77 years, due to documented knowledge that taste and smell diminishes with age, we will limit age to this range. * Individuals with a diagnosis of AUD (for the AUD cohort) OR without a diagnosis of AUD (for the non-AUD cohort) per clinician assessment * Able to provide their own consent. * Due to the extensive questionnaires (administered in English language only) that participants must complete independently, fluency in the English language is needed. Hence, participants must be able to read and understand English. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * Diagnosis by a medical professional of morbid obesity or BMI \> 40 or renal disease. * Any history of chronic rhinitis, eating disorder, chronic upper respiratory infection, chronic allergic rhinitis, or nasal polyps in the last 6 months of screening, or current daily use of nasal sprays. * Altered cranial nerves associated with taste and olfaction identified by neurological evaluation during physical exam (screening visit). * Positive pregnancy test, currently pregnant or breastfeeding. * Hypoglycemic drug intake. * Currently using medications known to inhibit taste response (GLP1 agonists). * Currently experiencing temporary change/loss of taste and/or smell (individual may be rescreened when symptoms resolve). * Persistent loss of taste and/or smell due to COVID-19 or other reason. * NIAAA employees/staff or subordinates/relatives/co-workers of NIAAA employees/staff or study investigators. fMRI Exclusion Criteria * Claustrophobia * Ferromagnetic metal in the cranial cavity or eye, e.g., aneurysm clip implanted neural stimulator, cochlear implant, ocular foreign body. * Presence of implanted cardiac pacemaker or auto-defibrillator. * Individuals with an insulin pump. * Presence of an irremovable body piercing. * Individuals who are pregnant or breastfeeding during screening, or who become pregnant during the study, will be excluded from participation due to risk of exposing the fetus to undue magnetic field hazards associated with MRI.