National Institute On Alcohol Abuse And Alcoholism (niaaa)

This study tests whether the drug apremilast can help reduce alcohol cravings in people with moderate to severe alcohol use disorder. About 100 adults seeking treatment will take either a low or high dose of apremilast or a placebo daily for several weeks. Researchers will measur…

This study explores whether suvorexant, a drug currently used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. Researchers will compare suvorexant to a placebo in 180 adults (ages 18-75) with AUD who are underg…

This study tests whether tirzepatide, a drug approved for weight management, can help people with alcohol use disorder and related liver disease drink less and improve liver health. About 120 adults will receive weekly injections of tirzepatide or a placebo for 12 weeks. Research…

This study looks at how the FDA-approved drug acamprosate affects brain function in people with moderate to severe alcohol use disorder. About 48 adults aged 21 to 65 will stay in the clinic for 21 days, taking either acamprosate or a placebo. Researchers will use EEG to measure …

This study looks at how a specific gene (CHRNA5) affects the way people experience alcohol and how their brains respond to alcohol-related cues. Researchers will give alcohol to healthy adults aged 21-60, including both smokers and non-smokers, and use brain scans and self-report…

This study follows up to 7,500 adults with and without alcohol use disorder to learn more about the condition. Researchers will collect health information, blood samples, and brain scans to better understand the biology and genetics behind alcohol problems. The goal is to improve…

This study looks at how a gene called ZIP8 may influence alcohol drinking and brain activity. Healthy volunteers aged 21 to 60 with European ancestry will receive alcohol through an IV and can press a button to get more. They will also have brain scans and complete tasks. The goa…

This study looks at whether the artificial sweetener sucralose changes how the body absorbs and processes certain medicines. Researchers will give healthy overweight Black and Hispanic women a daily sucralose capsule or a placebo for four weeks, then measure drug levels, hormones…

This study looks at how alcohol use disorder (AUD) affects a person's sense of taste and smell. Researchers will compare people with and without AUD using taste tests, smell tests, and brain activity measurements. The goal is to better understand these sensory changes, not to tes…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. About 1,000 adults aged 18 and older will participate in a single visit. No trea…

This early-stage study looks at whether tirzepatide, a drug used for diabetes and weight loss, changes brain activity related to alcohol cravings. About 176 adults with alcohol use disorder and healthy volunteers will receive tirzepatide or a placebo and undergo brain scans. The …

This study tests whether a drug called alirocumab, currently used for high cholesterol, is safe in people who drink heavily. About 100 healthy adults aged 21-65 who drink 20 or more alcoholic drinks per week will receive either the drug or a placebo. Researchers will monitor side…

This study aims to improve MRI and EEG techniques for studying how the brain works, especially related to addiction. Healthy adults aged 18 and older will undergo brain scans and perform simple tasks. The goal is to develop better methods for future research, not to treat any dis…

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorder and healthy volunteers. Participants will complete tasks either inside or outside an MRI scanner to see how the brain works. The goal is to d…

This study follows 1500 adults to understand how the COVID-19 pandemic has changed their drinking habits and stress levels. Participants complete surveys online or by phone over 2 years, reporting on alcohol use, mental health, and quality of life. No treatments or medications ar…