Diet soda ingredient may mess with your meds, study warns
NCT ID NCT03407079
First seen Jan 06, 2026 · Last updated Jun 19, 2026 · Updated 27 times
Summary
This study looks at whether sucralose, a common artificial sweetener, affects how the body absorbs and breaks down certain medications. Researchers will give healthy overweight volunteers either sucralose or a placebo for 28 days and measure changes in drug levels, hormones, gut bacteria, and fat cells. The goal is to understand if artificial sweeteners can interfere with medicine, which could have important implications for people who take regular medications.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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National Institutes of Health Clinical Center
RECRUITINGBethesda, Maryland, 20892, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
sucralose
What this could lead to
If it works, this could help doctors understand whether artificial sweeteners like sucralose affect how well medications work, leading to better dosing guidelines.
What could go wrong
This is an early-phase study with only 150 participants, so results may not apply to everyone. It's designed to gather knowledge, not to test a treatment.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.