HEALTHY VOLUNTEERS

This early-stage study tests the safety of a new drug called CPTX2309 in healthy people and those with moderate to severe rheumatoid arthritis or lupus. Researchers will give the drug through a vein and watch for side effects, changes in lab tests, and how the body responds. The …

This study explores whether suvorexant, a drug currently used for sleep problems, can help people with alcohol use disorder (AUD) by changing how the brain's dopamine system works. Researchers will compare suvorexant to a placebo in 180 adults (ages 18-75) with AUD who are underg…

This early-stage study tests whether IGT-303 is safe for people with chronic kidney disease. About 94 healthy volunteers and kidney disease patients will receive either the drug or a placebo. Researchers will monitor side effects and how the drug moves through the body.

This early-stage study tests an experimental drug called ALN-PNP in healthy adults and people with a type of fatty liver disease (MASLD) who have a specific gene variant. The main goal is to check the drug's safety and how well the body tolerates it. Researchers will also measure…

This study tests a new drug called JUV-161 in healthy volunteers aged 40 to 65 who will have one leg immobilized for several weeks. The goal is to see if the drug can prevent muscle loss and is safe. Participants receive weekly injections of either the drug or a placebo for about…

This early study tests a device that sends mild electrical pulses to the spinal cord and limbs to help people with paralysis or weakness from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend up to 5 sessions per week for a year, performing task…

This early-stage study tests a new drug, NNC4004-0002, in 60 adults with high uric acid but no symptoms. Participants receive either the drug or a placebo as a single injection under the skin. The main goal is to check safety and how the drug works in the body over about 7 months…

This study is the first time the drug Leucettinib-21 is being tested in humans. It will check the drug's safety in healthy volunteers and in people with Down syndrome or Alzheimer's disease. The goal is to see if the drug is safe and how the body processes it, which is a step tow…

This early-stage study tests a new medicine called BMS-986470 in healthy volunteers and people with sickle cell disease. The main goal is to check safety and how the body processes the drug. About 184 participants will take either the drug or a placebo to gather initial data on d…

This study is the first time MRT-8102, an experimental pill, is being tested in humans. It aims to check the drug's safety in 100 healthy adults and people at risk for heart problems with high CRP levels. Participants will take single or multiple doses of the drug or a placebo ov…

This early-phase study tests whether the experimental drug TAK-781 is safe and tolerable. First, healthy volunteers receive either the drug or a placebo. Then, a small group of people with primary sclerosing cholangitis (PSC) receive the drug. The study also measures how the body…

This early-stage study tests an experimental oral drug called RO7795081 in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to treat the condition. Participants will receive either the dru…

This early-stage study is testing a new medicine called NNC0581-0001 for people with fatty liver and suspected liver inflammation. About 48 adults will receive either the drug or a placebo as a monthly injection for three months. The main goal is to check safety and how the drug …

This early-stage study tests a new drug called MTX-101 in healthy adults and people with type 1 diabetes. The main goal is to check for side effects and see how the drug moves through the body. Researchers will also look at how MTX-101 affects immune cells. The study involves up …

This study tests a new PET imaging method that uses 10 to 100 times less radiation than standard scans to detect neuroendocrine tumors. Researchers will scan 200 healthy volunteers and tumor patients using a high-sensitivity scanner and a tracer that targets tumor proteins. The g…

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults, including healthy volunteers and those with memory problems, using a high-sensitivity scanner…

This study tests a new vaccine (PCV21) designed to protect babies against 21 types of pneumococcal bacteria, which can cause serious illnesses like pneumonia and meningitis. About 2,195 healthy infants will receive four doses of either the new vaccine or an existing one, starting…

This early-stage study tests a new drug, ABCL635, given as a shot under the skin. It first checks safety in healthy men and women, then looks at whether it can reduce the number and severity of hot flashes in postmenopausal women with moderate-to-severe symptoms. About 136 people…

This study tests a new drug called BGB-45035 for the first time in humans. It will check safety and how the body processes the drug in healthy volunteers, then test it in people with autoimmune skin diseases like eczema and prurigo nodularis. The goal is to see if the drug is saf…

This study tests whether a new software called Motion Reset can prevent or reduce cybersickness—symptoms like nausea, dizziness, and headache—in healthy adults using virtual reality. About 150 volunteers aged 18 to 60 will be split into three groups: one using the anti-sickness s…

This study tests whether a 12-week program combining modern dance with mindfulness practices can improve psychological wellbeing, reduce stress, and enhance body awareness in healthy adults. About 160 recreational dancers will be randomly assigned to either the dance-mindfulness …

This study looks at how your internal body clock changes the way you experience time when you stay awake for 36 hours. Healthy adults aged 23 to 45 will stay in a controlled lab, awake the whole time, with everything kept constant. Every two hours, they will do short tests on tim…

This early-stage study is testing a new drug called GenSci161 in 44 healthy adults aged 18 to 45. The main goal is to see if the drug is safe and how the body processes it after a single injection. Participants will be randomly assigned to receive either the drug or a placebo, an…

This study aims to make a Turkish version of a questionnaire that measures how sick people feel in virtual reality (VR). Researchers will ask 42 healthy volunteers to use VR and fill out the survey. The goal is to see if the Turkish version is as accurate as the original English …

This early-stage study tests an experimental drug called RO7763505 in healthy people and those with stable coronary artery disease. The main goal is to check safety and how the body processes the drug, not to treat the disease. About 196 participants will receive either the drug …

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to lean individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns, and collect genetic samples. About 2,000 healthy adu…

This study screens up to 16,000 people aged 3 to 99 with mood or anxiety disorders, as well as healthy volunteers, to see if they qualify for other research studies at the National Institute of Mental Health. Participants undergo interviews, medical exams, brain scans, and lab te…

This study is testing a new device that uses light to measure pulse wave velocity and blood pressure without needing a traditional cuff. Researchers will compare the device's readings to standard equipment in 27 healthy adults. The goal is to see if this light-based method is rel…

This study looks at whether a specific chest massage (intercostal mobilization) can improve breathing muscle strength, lung function, and walking performance in healthy adults. Researchers will divide 90 sedentary volunteers aged 18-30 into three groups: one receiving the massage…

This study looks at whether the artificial sweetener sucralose changes how the body absorbs and processes certain medicines. Researchers will give healthy overweight Black and Hispanic women a daily sucralose capsule or a placebo for four weeks, then measure drug levels, hormones…

This study collects blood, stool, saliva, and skin swabs from 600 healthy volunteers aged 3 to 80. The samples help researchers develop and improve laboratory tests. Participants are not treated for any condition; they simply donate samples over up to 5 years.

This early-stage study is testing a new drug, ME3241, in healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body processes it. About 104 participants will receive either the drug or a placebo. This study does not aim to treat any disease.

This study looks at how energy drinks change the heart's electrical signals in healthy adults aged 18-40. Only 3 people will take part, and each will try 8 different drinks or a placebo. The goal is to see if these drinks can cause unsafe changes in heart rhythm.

This study looks at how healthy adults use rhythm and timing to understand speech and other sounds. Researchers will use brain scans (EEG and MEG) and behavioral tests to measure brain activity. The goal is to learn more about how we predict when sounds will happen, which could h…

This early-stage study tests a single dose of an experimental drug called VV261 in 58 healthy adults aged 18 to 45. The goal is to see if the drug is safe and how the body processes it. Participants are randomly assigned to receive either the drug or a placebo, and no one knows w…

This study looks at whether putting a special tape on the diaphragm (the main breathing muscle) can make high-intensity interval training (HIIT) more effective. Thirty trained adults aged 18-35 will either do HIIT alone or HIIT with the tape for 8 weeks. Researchers will measure …

This study screens healthy adults aged 18 and older to see if they qualify for future infectious disease vaccine or treatment trials. Participants provide basic health information and demographics. The goal is to speed up enrollment into other research studies at the center.

This study looks at how things you're not aware of, like how a choice is presented or your age, can affect the decisions you make. Researchers will work with 200 healthy adults to measure things like how much you avoid losses versus seeking gains. The goal is to create a baseline…

This study looks at how healthy people's brains process social information, like understanding others' feelings. Researchers will use brain scans (fMRI) and brain wave recordings (EEG) to see which brain areas are active during social tasks. The goal is to create a baseline of no…

This study collects blood samples from 1,000 healthy adults aged 18 and older to help researchers understand blood vessel and immune system diseases. Participants donate about 10 tablespoons of blood and may return for up to 10 years. The samples are used to develop tests and stu…

This study aims to develop better ways to perform MRI scans by testing new imaging techniques in healthy volunteers and current NIH participants. Up to 1,000 adults aged 18 and older will have one or more MRI scans, each lasting 20 minutes to 2 hours, with some requiring contrast…

This early-stage study tests a single dose of VV913 capsules in 56 healthy Chinese men to see if it is safe and how the body processes it. Participants are randomly assigned to receive either the drug or a placebo. The study does not aim to treat any disease, but to gather import…

This study tests a new non-invasive technique called temporal interference (TI) to stimulate deep brain areas in 30 healthy adults aged 18-50. Researchers will use brain scans to see if TI can safely activate deep regions without affecting the brain's surface. The goal is to bett…

This study aims to create a large collection of medical images (MRI and ultrasound) from 2400 healthy volunteers across France. Researchers will analyze the heart, liver, and blood vessels to understand what normal aging looks like versus disease. The goal is to improve early det…

This study looks at how a new drug called KarXT changes the levels of three other drugs (midazolam, fexofenadine, and digoxin) in the body. It involves 60 healthy adults and aims to see if KarXT causes any drug interactions. The results will help doctors understand how to use Kar…

This study looks at whether adding natural nitrate (found in leafy greens and beetroot) to common foods like cereal bars, porridge, and biscuits can help the body produce more nitric oxide, which may lower blood pressure. Thirty healthy adults will eat these fortified foods in a …

This study looks at how consistent grip force sense measurements are when taken at different times in healthy adults aged 18-24. Researchers will use a simple hand-held device to measure how accurately people can match a target grip force. The goal is to see if this easy test can…

This study is the first time AKB-9090 is being tested in humans. It aims to check the drug's safety and how the body processes it in about 70 healthy adults. Participants receive either the drug or a placebo, and researchers monitor for side effects and measure drug levels in the…

This study looks at how eating a standard meal changes the way a new drug, VV119, is processed in the body. It involves 16 healthy Chinese adults who will take a single dose of VV119 with and without food. The goal is to see if food affects drug levels and safety, helping guide f…

This study looks at how different parts of the brain work together when people decide whether to put in effort for a reward. Researchers will use safe, non-invasive brain stimulation and brain scans in 204 healthy adults aged 18-40. The goal is to understand the brain circuits be…

This early-stage study tests whether a new drug called CHF6467, given as a nasal spray, is safe and tolerable in 68 healthy adults aged 18 to 55. Researchers will also measure how the drug moves in the blood and spinal fluid, and whether the body makes antibodies against it. The …

This early-stage study is testing a new drug called RO7806881 in 128 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor for side effects. The goal is to gather safety information,…

This study aims to define normal test results for spatial neglect, a common attention disorder after stroke. Researchers will test 210 healthy French-speaking volunteers aged 20 to 89 to see how age, sex, and education affect scores. These norms will help doctors better diagnose …

This study looks at how the length of your training sessions affects your body's ability to keep going during long exercise. Researchers will compare two groups of healthy volunteers: one doing long sessions and one doing short sessions. The goal is to see which group better main…

This early-stage study tests a new drug called HW241045 in 56 healthy adults to see if it is safe and how the body processes it. Participants receive a single dose and are monitored for side effects. This is a necessary first step before testing the drug in people with a lung con…

This early-stage study is testing a new drug, KLA478, in 40 healthy adults aged 18 to 45. The main goal is to see if the drug is safe and how the body processes it. Participants receive a single dose and are monitored for side effects and drug levels in the blood. No treatment fo…

This study looks at how two common drugs (itraconazole and rifampin) change the amount of AR-LDD (BMS-986365) in the blood of healthy adult men. About 42 participants will take AR-LDD alone and then with each other drug to compare levels. The goal is to understand drug interactio…

This early-phase study is testing the safety and how the body processes three experimental drugs (DWJ1622, DWC202313, and DWC202314) in 40 healthy adults. Participants take a single dose on an empty stomach and are monitored closely. The goal is to gather important safety and dru…

This early-stage study tests a single dose of Alpha-0261 tablets in 60 healthy adults aged 18 to 55. The main goal is to check the drug's safety and how the body processes it. No treatment is being given for any disease; this is a first step to see if the drug is safe enough for …

This early-stage study is testing whether a combination of psilocybin (the active ingredient in magic mushrooms) and D-serine (an amino acid) is safe and how it affects the mind. Ten healthy adults aged 25-60 will receive one of two dose levels. The goal is to see if D-serine can…

This early-phase study tests the safety and tolerability of a new drug called MT-251 in 70 healthy adults aged 19 to 55. Participants receive either the drug or a placebo to monitor side effects and how the body processes the drug. No treatment benefit is expected; the goal is to…

This study tests whether a new drug called B-3E07 works like the approved drug Forsteo in the body. It involves 48 healthy adult women who will receive a single dose of each drug at different times. The goal is to see if the new drug is similar enough to Forsteo to move forward i…

This study tests whether a synbiotic supplement (a powder containing a natural sugar from human milk) can increase helpful gut bacteria in healthy adults. One hundred participants aged 18 and older who eat a typical Western diet and take no regular medications will take the suppl…

This study looks at how a part of the brain called the posterior parietal cortex helps us combine vision and body position to reach for objects. Researchers will compare people with optic ataxia (a condition that affects reaching) and healthy volunteers using simple behavioral te…

This study aims to collect skin and gut samples from 5,000 healthy volunteers to create a detailed map of the bacteria and fungi living on and inside us. Researchers will look for unique patterns linked to factors like diet, medications, and where you live. The goal is to better …

This study collects blood, urine, saliva, and tumor tissue from 500 adults with or at risk for urothelial cancer (bladder, ureter, urethra). Researchers will analyze the DNA and other molecular features of these samples to understand what causes the cancer and how it responds to …

This study looks at how changing the amount of protein, fat, carbs, and total calories in your diet affects the energy your body uses to digest food. Healthy adults aged 18 to 60 will stay in a clinic for about 35 days, eating only provided meals and spending 9 separate 24-hour p…

This study looks at how certain brain activity patterns, called explosive synchronization, relate to chronic pain in people with fibromyalgia. Researchers will compare brain scans of 150 participants (fibromyalgia patients and healthy volunteers) and test whether a gentle, non-in…

This study tests a new way to track platelets after a transfusion using biotin (vitamin B7) and a small amount of radioactive material. Healthy volunteers donate their own platelets, which are labeled with biotin, stored for 3 days, then given back with a radioactive tag. Follow-…

This study looks at how healthy adults absorb and process kaempferol, a natural compound found in many plants. Researchers will give participants kaempferol and collect blood and urine samples to measure its levels in the body. The goal is to better understand how kaempferol work…

This study collects biological samples like blood, skin, and saliva from people with skin diseases, their family members, and healthy volunteers. The goal is to learn what causes different skin conditions and find better ways to treat them. Participants may also answer a survey a…

This study is for healthy adults to see how different tablet versions of the drug BMS-986435 are absorbed by the body. It also checks if eating food changes how the drug works. About 140 participants will take part to help researchers understand the best tablet form.

This early-stage study tests a single inhaled dose of RJ026 in 42 healthy volunteers and 42 people with interstitial lung disease (ILD). The goal is to measure how the drug moves through the body and check for side effects, not to treat the disease. Participants receive one of th…

This early-phase study is testing a new substance called RAD301 to see how it moves through the body and how much radiation it gives off. It involves 9 people: healthy volunteers and patients with certain cancers like pancreatic, lung, or ovarian cancer. The goal is to measure sa…

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy adults aged 18 to 64. Participants receive one dose and are closely monitored for side effects. The study does not aim to treat any disease, but to gather important safety and…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will use interviews, blood tests, brain scans, and sleep monitoring to compare four groups: people with recent suicidal thoughts or attempts, those with past suicida…

This study looks for better ways to measure what people eat, specifically sugar. Instead of relying on food diaries, researchers want to see if stable isotopes in blood, hair, and other samples can accurately track sugar intake. Sixty healthy adults will stay at a research center…

This study gives a single dose of a radiolabeled drug (E2086) to 10 healthy men to see how it is broken down and removed from the body. Researchers will measure the drug and its byproducts in blood, urine, and stool. The goal is to understand the drug's metabolism and excretion, …

This early-stage study is testing a new drug, MT-701, in 78 healthy adults aged 19 to 55. The goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor for side effects. This study does…

This study collects blood, bone marrow, and cheek cell samples from healthy volunteers ages 8 and older. Researchers use these samples to study blood cell formation, viral blood diseases, immune system function, and genetic risks for aplastic anemia. The goal is to provide essent…

This study tests a special imaging technique called adaptive optics to take super-detailed pictures of the retina. Researchers hope this can help find eye diseases earlier, before serious damage occurs. Up to 1,000 people aged 12 and older, with or without eye disease, will parti…

This early-stage study is testing a new drug called ABBV-243 in healthy adults to see if it is safe and how the body processes it. About 66 participants will receive either the drug or a placebo, given as an injection or IV. The study does not aim to treat any disease; it is pure…

This early-stage study tests an experimental drug called BMS-986521 in healthy adults to see if it is safe and how the body processes it. About 106 participants will receive either the drug or a placebo. The study does not aim to treat any disease; it simply gathers important saf…

This early-stage study checks if LIFE-001 is safe for people. About 150 healthy adults aged 18 to 65 will receive the drug and be monitored for side effects and how the drug moves through their body. The goal is to gather basic safety information before testing it in patients.

This early-stage study is testing a new drug, CLYM116, in 48 healthy adults aged 18 to 60. The main goal is to see if the drug is safe and how the body processes it after one or several injections under the skin. Participants will be randomly assigned to receive either the drug o…

This study looks at how social and cultural factors affect how people express pain and how others judge that pain. Researchers will measure pain responses in healthy volunteers and then test whether observers can accurately estimate someone else's pain. The goal is to understand …

This early-stage study is testing how safe three experimental drugs (DWJ1622, DWC202313, and DWC202314) are and how they move through the body. It involves 36 healthy adults who will take the drugs after a meal. The goal is to gather basic safety and drug-level information, not t…

This study uses brain scans (fMRI) and behavioral tests to understand how aging changes decision-making and self-control in healthy people. Researchers will recruit 150 adults to complete tasks and undergo imaging. The goal is to create a baseline for future studies on brain diso…

This study tests how a new drug called repinatrabit interacts with several common medications, including birth control pills, metformin, carbamazepine, rosuvastatin, and methotrexate. It involves 48 healthy volunteers and aims to measure drug levels in the blood. The results will…

This early-stage study is testing a new drug called YN001 in 24 healthy adults aged 18 to 65. The goal is to measure how the drug moves through the body, how long it stays, and whether it causes any side effects. Participants receive a single dose and are monitored closely. This …

This early-stage study tests the safety and how the body handles the experimental drug SEP-479 in 150 healthy adults aged 21 to 60. Participants receive single or multiple doses of the drug or a placebo. The goal is to check for side effects and measure drug levels in the blood, …

This study tests a new method called temporal interference (TI) that uses electrical stimulation to reach deep brain areas without surgery. Researchers will scan the brains of 30 healthy adults using fMRI to see how different stimulation patterns affect brain activity. The goal i…

This study looks at whether taking vitamin and mineral supplements for 12 weeks can improve skin health and how people feel about their overall health. It involves 120 healthy Chinese adults who don't eat many fruits and vegetables. Participants will be randomly assigned to take …

This study looks at how transcranial magnetic stimulation (TMS) changes brain activity in healthy adults. TMS uses magnetic pulses to stimulate the brain and is already approved for depression. Researchers want to understand these effects better to design treatments for drug addi…

This study is a planning step for future clinical trials. It will test brain imaging and heart monitoring equipment in 150 healthy volunteers, people with Parkinson's disease, and those with paralysis. The goal is to make sure the tools and procedures work well before larger stud…

This study aims to understand how laser light reflects from different parts of the eye, such as the cornea and retina. Researchers will measure the reflected laser radiation at various angles and wavelengths in 20 healthy volunteers aged 18-40. The goal is to improve the safety a…

This early-stage study is testing the safety of a new drug called ARGX-124 in healthy adults. Researchers will also measure how the drug moves through the body and how the immune system reacts. The study involves 104 participants and lasts up to 23 weeks. It does not aim to treat…

This study looks at how a person's genes (specifically CYP2D6) affect the way their body processes the drug KarXT. It involves 56 healthy adults who are grouped by their gene type. The goal is to understand drug levels and safety, not to treat any disease.

This study explores whether training your motor skills (like hand movements) can also improve your ability to learn a language. The idea is that the brain changes that happen during motor learning might also help with language functions that use the same brain areas. The study wi…

This early-stage study tests a new drug called RO7875913 in 40 healthy volunteers to see if it is safe and how the body processes it. Participants must be adults with a healthy weight and no serious medical conditions. The study does not aim to treat any disease, but to gather im…

This study follows 1,500 children ages 8-17 over several years to understand how genes, sleep, mood, and thinking skills affect eating behavior and health. Participants wear a wrist monitor, answer smartphone questions, and have yearly check-ups including body measurements, blood…

This study is creating a large, detailed database of healthy Caucasian knees using advanced CT scans, X-rays, and ultrasound. Researchers will measure knee shape, alignment, and ligament balance in 200 volunteers aged 20-35. The goal is to better understand normal knee anatomy to…

This study looks at how people use hearing versus physical sensation to monitor their speech. Healthy adults will complete speech tasks where their hearing is altered in real time, sometimes with a visual display. A computer model will estimate each person's reliance on hearing, …

This study tests whether virtual reality and mental imagery can replace traditional prism adaptation therapy for people with unilateral neglect after a brain injury. Researchers will first work with 480 healthy volunteers to see if these new methods work similarly to the standard…

This study looks at biomarkers—substances in blood and tissues—to understand how people age. Researchers will follow 900 healthy and frail adults for years, doing tests like blood draws, memory checks, and scans. The goal is to find ways to improve quality of life in old age.

This study collects blood and urine samples from healthy volunteers and patients to help researchers study genes, proteins, and other substances. The goal is to develop new lab tests and better understand diseases. Participants must be 18 or older and can join if they have certai…

This study looks at how a wearable robotic hip device affects the way healthy adults walk. Researchers will measure step length, speed, muscle activity, and foot pressure under different levels of assistance from the exoskeleton. The goal is to understand how the device changes n…

This study looks at how sleep improves visual learning. Ten healthy volunteers aged 18-30 will have their brains scanned with MRI while sleeping to see how the brain processes visual information. The goal is to understand the brain activity behind learning during sleep.

This early-stage study is testing a new drug, ZP9830, in 124 healthy volunteers aged 18 to 45. The main goal is to see if the drug is safe and how the body processes it. No treatment benefit is expected, as the study is designed to gather safety information before testing in pati…

This early-stage study is testing a new drug, LAD106, in 93 healthy adults aged 18 to 45. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo. This study does not aim to treat any disease, but to gath…

This study aims to understand how psychological factors, such as expectations and emotions, influence the way we perceive pain. Healthy volunteers aged 18-50 will undergo brain scans (MRI) and pain tests (heat or electric shocks) while their heart rate, breathing, and other respo…

This study looks at how much of the drug KarXT gets into the breast milk and blood of healthy women who are breastfeeding. Eight mothers will take KarXT and provide milk and blood samples over 24 hours. The goal is to estimate how much of the drug a nursing baby might receive and…

This study collects blood plasma and white blood cells from healthy volunteers, HIV patients, and their relatives using a procedure called apheresis. The samples are used for laboratory research on HIV and immune function. Participants must be 18 or older and enrolled in an NIH s…

This early-stage study is testing new versions of two experimental drugs, KarX and KarT, in 72 healthy adults. The goal is to measure how the body absorbs and processes these new formulas compared to the original versions, and to see if food changes how they work. This research d…

This study tests a new device called pneuRIP that measures breathing without needles or tubes. It will be used on 20 children—10 healthy and 10 with mild breathing problems from muscle diseases. The goal is to see if the new monitor works as well as an existing one.

This early-stage study tests a new drug called PBK_M2301 in 32 healthy adults aged 19 to 65. The goal is to measure how much of the drug gets into the blood and check for any safety issues. Participants will take the drug once and provide blood samples over time. This study does …

This study looks at whether emergency medicine doctors can use ultrasound to clearly see the muscle layers of the belly wall, which is needed for a type of pain block called a TAP block. About 118 healthy adults will have an ultrasound scan of their abdomen. The goal is to see if…

This early-stage study tests the safety and tolerability of a new drug called ALN-4285 in 76 healthy adults. Participants receive a single injection of either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The goal is to g…

This early-stage study is testing a new drug called ABCL575 for the first time in people. It involves 40 healthy adults who will receive either a single dose of ABCL575 or a placebo. The main goal is to check if the drug is safe and how the body handles it. No treatment benefit i…

This study collects white blood cells from healthy volunteers using a procedure called cytapheresis. The cells are used for lab research only, not to treat any disease. Participants must be at least 18 years old and can donate up to six times per year.

This study collects blood, bone marrow, urine, and tissue samples from people with cancer or blood disorders, as well as from their healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, improve treatments, and find ne…

This study tests whether the experimental drug BMS-986278 changes the heart's electrical activity in 32 healthy adults aged 18 to 55. Participants receive the drug, a placebo, and a positive control in random order. The goal is to check for heart rhythm risks, not to treat any di…

This study aims to develop better MRI techniques for imaging the heart and blood vessels, avoiding the radiation used in standard X-ray tests. Researchers will compare these new MRI methods with traditional angiography and CT scans in up to 4,000 adults, including healthy volunte…

This study aims to measure how quickly proteins in the body are replaced (protein turnover) in healthy adults of different ages. Participants will drink small amounts of safe heavy water for 21 days and undergo tests including muscle and fat biopsies, imaging scans, and strength …