HEALTHY VOLUNTEERS

This study is testing a new vaccine designed to protect against four types of meningococcal bacteria (A, C, Y, W) that can cause serious meningitis and blood infections. It will involve about 1,602 healthy children and adolescents aged 2 to 17 in China. Researchers will compare t…

This study is testing a new version of a vaccine that protects against serious bacterial infections like pneumonia and meningitis. It will compare the safety and immune response of the new 21-strain vaccine against a currently licensed 20-strain vaccine in healthy infants. Babies…

This is an early safety study for a new drug called TAK-781. It will first test the drug in healthy volunteers to see if it is safe and how the body processes it. Then, a small group of people with a serious liver disease called primary sclerosing cholangitis (PSC) will receive a…

This is the first human study testing an experimental drug called CPTX2309. Researchers want to see if it's safe and how the body handles it in healthy volunteers and people with moderate to severe rheumatoid arthritis or lupus. The study will test different doses given through a…

This early-stage study is testing a new oral medication called RO7763505 to see if it's safe for people. Researchers will give the drug to healthy volunteers and people with stable coronary artery disease to check for side effects and how the body processes it. The study will hel…

This early-stage study is testing a new drug called BMS-986470 in healthy volunteers and people with sickle cell disease. Researchers want to understand if the drug is safe, how it moves through the body, and whether it can help increase healthy hemoglobin levels in sickle cell p…

This early-stage study is testing whether gentle electrical stimulation applied to the skin over nerves and the spinal cord can help improve arm, hand, or leg movements in people with paralysis or weakness. Researchers are recruiting 64 adults with conditions like stroke or spina…

This is the first time a new drug called BGB-45035 is being tested in people. The main goal is to check if it is safe and how the body processes it. The study will first give the drug to healthy volunteers at different doses. Later, a small group of adults with itchy skin conditi…

This is a very early-stage study testing an experimental drug called ALN-PNP in healthy adults and people with a common fatty liver disease (MASLD). The main goal is to check the drug's safety, how the body processes it, and see if it can reduce liver fat. Researchers will also s…

This is the first time a new drug called NNC4004-0002 is being given to people. The study aims to see if it is safe and how well the body tolerates it in adults with high uric acid levels but no symptoms. Researchers will also check if a single injection can lower uric acid in th…

This early-stage study aims to find out if a new drug called IGT-303 is safe for people. It will test single and multiple doses given as shots under the skin or into a vein. Researchers will compare the drug to a placebo in about 94 healthy volunteers and people with chronic kidn…

This is the first study in people to test the safety of an experimental oral drug called Leucettinib-21. It will first be given to healthy volunteers to check for side effects and how the body processes it. Later, a single dose will be given to a small group of men with Down synd…

This study is testing a new prototype device that aims to measure blood pressure continuously and comfortably. It uses light sensors on the skin to track pulse waves instead of squeezing the arm with a cuff. Researchers are enrolling 27 healthy volunteers to see if this new metho…

This study is testing a new type of PET scan that uses much less radiation to detect and monitor neuroendocrine tumors. Researchers want to see if they can reduce the radiation dose by 10 to 100 times while still getting clear images. The trial will enroll 200 people, including b…

This study is testing a new device called the pneuRIP that monitors breathing without being invasive. It uses soft bands around the chest and belly to measure breathing patterns wirelessly. Researchers are comparing this new device to an older system in 10 healthy children and 10…

This study is testing whether new software called 'Motion Reset' can prevent or reduce motion sickness (cybersickness) in people using virtual reality. Healthy volunteers will try different VR experiences and then play a game, reporting any discomfort like nausea or dizziness. Th…

This study is testing whether a non-invasive brain stimulation technique can reduce chronic pain in people with fibromyalgia. Researchers will compare brain activity in people with fibromyalgia to healthy volunteers, then test if targeted stimulation can change this activity and …

This study is testing if a special elastic tape applied to the breathing muscles helps people get more benefit from high-intensity interval training (HIIT). Thirty trained adults will do an 8-week cycling workout program, with half also getting the tape before each session. Resea…

This study is testing whether a 12-week program combining modern dance with mindfulness practices can improve mental wellbeing in adults who dance for fun. About 160 participants will either take the weekly dance-mindfulness classes or continue their usual activities for comparis…

This study is testing whether taking a combination of antioxidant and multivitamin supplements for 12 weeks can improve skin health and how people feel about their overall physical health. It will involve 120 healthy Chinese adults who don't eat many fruits and vegetables. Partic…

This study is testing a new drug called ABCL635, given as an injection under the skin, to see if it can safely reduce hot flashes and night sweats in postmenopausal women. Researchers will first test it in healthy men and women, then specifically in women with moderate-to-severe …

This study collects blood, cheek cell, and bone marrow samples from healthy volunteers to support laboratory research. The samples help scientists study how blood cells form normally, investigate viral blood diseases, and understand genetic risk factors for conditions like aplast…

This is an early safety study testing a new drug called LAD106 in healthy volunteers. The main goal is to see how safe the drug is, how the body processes it, and what side effects might occur. Researchers will test different single and multiple doses in small groups of healthy a…

This is an early safety study testing a new oral medication called Alpha-0261 in healthy volunteers. Researchers will give single doses to 60 healthy adults to check for side effects and see how the body processes the drug. The main goal is to determine if the tablet is safe and …

This study aims to collect biological samples from healthy volunteers to help researchers develop and improve laboratory tests used in medical research. Participants ages 3-80 will provide blood, saliva, stool, and skin/mucus swabs during visits over several years. The samples wi…

This study aims to collect blood and urine samples from healthy adults and patients with certain heart, lung, or blood vessel conditions. The samples will be used by researchers to develop new laboratory tests and to better understand how genes, proteins, and other substances in …

This research aims to understand why people from different racial backgrounds experience and assess pain differently. The study involves healthy volunteers who will either experience mild pain or observe others in pain, while researchers measure their reactions. The goal is to id…

This study is preparing for future research by testing different brain and body scan procedures. Researchers will work with healthy volunteers, people with Parkinson's disease, and people with paralysis to see if the scans are practical and comfortable. The goal is to figure out …

This study aims to collect blood, bone marrow, urine, and tissue samples from patients with cancer or blood disorders, as well as from some of their family members. The samples will be used in laboratory research to help scientists better understand these diseases, evaluate curre…

This is an early safety study testing an experimental drug called ABBV-243 in healthy volunteers. Researchers want to understand how safe the drug is and how the body processes it. The study involves 66 healthy adults who will receive either the drug or a placebo, with special at…

This is the first time researchers are testing a new biologic drug called MT-701 in people. The study aims to check if the drug is safe and how the body handles it in 78 healthy volunteers. Participants will receive either the drug or a placebo, and researchers will monitor for a…

This study aims to develop better MRI scanning methods and create new imaging techniques. Researchers are recruiting 1,000 healthy volunteers and people with cardiac risk factors to undergo MRI scans that will help optimize scanning parameters. Participants will have one or more …

This is the first study in people to test the safety of a new drug called SL-325. It will involve 72 healthy volunteers who will receive either the drug or a placebo. The main goal is to see how safe the drug is and how the body processes it, starting with low doses and gradually…

This study aims to understand the biological processes of aging by collecting detailed health data and samples from 900 adults over many years. Participants, including healthy, non-frail, and frail individuals, will undergo regular tests like blood draws, scans, and biopsies ever…

This early-stage study aims to understand the safety and radiation exposure of an experimental imaging agent called RAD301. It will involve 9 participants, including both healthy volunteers and people with certain solid tumors like pancreatic or lung cancer. Participants will rec…

This study aims to collect blood, urine, saliva, and tissue samples from people with bladder/urinary tract cancer and healthy volunteers. Researchers will compare these samples to understand what genetic and cellular changes cause this cancer to develop. The goal is to identify n…

This is the first study testing CLYM116 in people. Researchers want to see if this experimental antibody is safe and how it behaves in the body. The study will enroll 48 healthy adults who will receive either the drug or a placebo. The main goal is to check for side effects and m…

This study aims to understand how damage to a specific brain area affects vision, movement, and daily life in people with optic ataxia. Researchers will compare 160 participants—some with optic ataxia and some healthy—using simple movement and perception tests. The goal is to lea…

This study aims to understand how energy drinks affect heart rhythm and other health measures in healthy adults. Three participants will try different drinks and ingredients while researchers monitor their heart activity, blood pressure, and blood sugar. The goal is to gather saf…

This study aims to establish normal score ranges for French-language tests used to diagnose spatial neglect, a common attention disorder after a stroke. Researchers will recruit 210 healthy volunteers, grouped by age and gender, to complete a series of paper-and-pencil tests. The…

This study aims to understand how sleep helps people learn visual skills. Researchers will scan the brains of 10 healthy volunteers while they nap, before and after visual training. The goal is to see if the brain processes specific visual information during sleep, which could ex…

This is the first study testing a new drug called RBD1119 in humans. Researchers will give increasing doses to 32 healthy volunteers to check if it's safe and how the body processes it. The main goal is to see what side effects occur and how the drug affects blood clotting pathwa…

This is the first study in humans for a new drug called MTX-101. Researchers want to understand its safety, how long it stays in the body, and how it affects immune cells. The study will involve healthy adults and people with type 1 diabetes to gather initial data.

This study aims to develop new, at-home rehabilitation methods for people with a brain injury condition called 'unilateral neglect,' which affects spatial awareness. Researchers are testing whether virtual reality or mental imagery exercises can work as well as current hospital-b…

This is the first study testing the experimental drug ABBV-277 in humans. Researchers will give single doses to 40 healthy volunteers to check for safety and see how the body processes the drug. The main goal is to understand side effects and how long the drug stays in the bloods…

This study aims to understand how the brain makes decisions about putting in effort for a reward. Researchers will use safe, non-invasive brain scans and stimulation techniques on 204 healthy volunteers to see which brain circuits are involved. The goal is to build knowledge that…

This study aims to understand how our internal body clock and sleepiness affect how we perceive time. Healthy adult volunteers will stay awake for about 36 hours in a controlled lab while taking regular tests on time perception, alertness, and mood. By measuring these changes alo…

This study aims to see how well emergency room doctors can use ultrasound machines to clearly see the layers of abdominal wall muscles. The goal is to understand if they could use this view to perform a specific type of pain-blocking injection called a TAP block. Researchers are …

This is the very first study in people for a new drug called MT-251. Its main goal is to check if the drug is safe and how the body processes it in 70 healthy volunteers. Researchers will give participants either the drug or a placebo and closely monitor them. The results will he…

This is the first study in humans to test a new inhaled compound called RCS-21. The main goal is to check if it is safe and how the body processes it. Healthy volunteers will inhale a single dose and be closely monitored for side effects. This is an early, basic safety study, not…

This study aims to see how reliable a simple grip strength test is for measuring a body's sense of position and movement (proprioception). Healthy volunteers aged 18-24 will squeeze a hand-held device to match specific force levels in two sessions one week apart. The goal is to v…

This early-stage study aims to check if an experimental drug called BMS-986278 affects the heart's electrical rhythm. Researchers will give the drug to 32 healthy adults and carefully monitor their heart activity. The main goal is to gather safety data before testing the drug in …

This research study aims to understand how our brains predict the timing of sounds and speech. Researchers will measure brain activity in healthy volunteers while they listen to different sounds and speech patterns. The goal is to learn how we use past patterns to anticipate what…

This is a very early, first-in-human study to understand how a new drug called YN001 moves through the body and how safe it is. It will involve 24 healthy adult volunteers who will receive a single dose. The main goal is to measure the drug's levels in the blood over time and che…

This study aims to understand how a wearable robotic hip exoskeleton changes the way people walk. Researchers will measure step length, walking speed, joint movement, and muscle activity in 15 healthy adults while they use the device. The goal is to gather basic knowledge about h…

This early-stage study aims to understand how eating a standard meal affects how the body absorbs and processes a single dose of an investigational capsule called VV119. It will involve 16 healthy Chinese adult volunteers who will take the capsule either with or without food in a…

This is the first study in humans to test a new drug called KLA478. It aims to check if the drug is safe and how the body absorbs and processes it. The study will involve 40 healthy volunteers who will receive a single dose. The main goal is to gather initial safety data and unde…

This study is testing a new, non-invasive brain stimulation technique called Temporal Interference (TI) on healthy volunteers. Researchers want to see if TI can safely and precisely activate deep brain areas without affecting the surface of the brain, using an MRI scanner to meas…

This study aims to find out if consuming the artificial sweetener sucralose changes how the body absorbs and processes certain medications. Researchers are enrolling 150 overweight or obese Black and Hispanic women to take either sucralose or a placebo pill for a month. They will…

This is the first study in humans for the investigational drug ALN-4285. It aims to test the safety and how the body processes a single injection of the drug in 76 healthy adult volunteers. The study will start with low doses and gradually increase them to find a safe range for f…

This is the first study testing a new drug called selonabant in people. Researchers want to see if it's safe and how the body handles it when given through an IV. They're enrolling 40 healthy adults aged 18-30 who will receive either the drug or a placebo. The main goal is to che…

This study is testing whether adding a natural compound called nitrate to common foods like cereal bars, porridge, and biscuits can help the body produce more nitric oxide, which may lower blood pressure. Thirty healthy volunteers will try all three fortified foods in a random or…

This early-stage study aims to check the safety of a new drug called ARGX-124 in healthy adults. Researchers will measure how much of the drug stays in the blood and how the body's immune system reacts to it. The study will involve about 104 healthy volunteers who will be monitor…

This early-stage study aims to understand how two common medications (itraconazole and rifampin) affect the body's processing of an experimental drug called AR-LDD. The research involves 42 healthy adult male volunteers who will take AR-LDD alone and then with each of the other m…

This study is not a treatment trial. Its main purpose is to screen a large number of people—including those with mood or anxiety disorders and healthy volunteers—to understand these conditions better and to find suitable participants for future research studies. Participants unde…

This early-stage study aims to understand how the body absorbs a new drug called ENX-104. It will test 12 healthy volunteers to see if taking the drug as a liquid or a pill, and with or without a high-fat meal, changes how much drug gets into the bloodstream. The main goals are t…

This study aims to understand how psychological factors like expectations and emotions change how we feel pain. Researchers will recruit 500 healthy volunteers to undergo brain scans and simple tests involving mild, brief pain or other sensations. The goal is to map how the brain…

This is the first study testing a new drug called ZP9830 in humans. Researchers will give the drug to 124 healthy volunteers to check for side effects and see how the body handles it. The study will compare people who get the real drug to those who get a placebo (inactive substan…

This study aims to collect blood samples from healthy adults to help researchers better understand and test for blood vessel and immune system diseases. Researchers will use these samples to establish what 'normal' looks like, which helps them develop more accurate tests and stud…

This is the first time researchers are testing a new drug called ABCL575 in people. The study will check if the drug is safe and how the body handles it in 40 healthy volunteers. Participants will receive either the drug or a placebo (inactive substance) in gradually increasing d…

This is a first-in-human study to understand how a new inhaled drug, RJ026, moves through the body and how safe it is. It will enroll 84 people, including healthy volunteers and patients with interstitial lung disease (ILD), a condition that causes lung scarring. Researchers will…

This is the first study in humans to test the safety and how the body processes a new tablet called HW241045. The trial involves 56 healthy volunteers who will receive either the tablet or a placebo. Researchers will monitor for side effects and measure how the drug moves through…

This study aims to understand what causes various skin diseases by collecting biological samples from participants. Researchers will gather skin, blood, saliva, and other samples from people with skin conditions, their family members, and healthy volunteers. The collected samples…

This study aims to understand the many factors that influence body weight by observing and measuring physical and behavioral traits in adults. Researchers are recruiting 2,000 healthy adults of all body sizes—lean, overweight, and obese—to participate. The study involves detailed…

This is the very first study to give the experimental drug MRT-8102 to people. Its main goal is to check if the drug is safe and how the body processes it. The study will involve 100 healthy adults and adults with risk factors for heart disease who have a specific blood marker (C…

This is an early safety study to see if a single dose of an investigational drug called balinatunfib affects the electrical timing of the heart in healthy people. It will involve 44 healthy adult volunteers who will receive the drug, a placebo, and a comparison drug in a specific…

This study aims to create detailed reference images of what healthy hearts and livers look like at different ages and between sexes. Researchers will use MRI and ultrasound scans on 2,400 healthy French adults to establish normal ranges for heart function, liver fat, and body fat…

This is an early safety study for a new pill called PBK_M2301, which combines two ingredients for cough. It aims to see how the drug moves through the body and if it's safe. Researchers will give the pill to 32 healthy adults and compare it to two separate reference drugs. The ma…

This study aims to understand how a new drug called KarXT changes the way the body processes three other common medications: midazolam (a sedative), fexofenadine (an allergy medicine), and digoxin (a heart medicine). It will involve 60 healthy adult volunteers. Researchers will m…

This early-stage study aims to understand how eating food and taking a common stomach acid medicine (rabeprazole) affect how the body absorbs a new drug called ZN-A-1041. It will involve 48 healthy volunteers who will take the drug under different conditions (like with a high-fat…

This is a very early, first-in-human study to check if a new drug called RO7806881 is safe for people and to see how the body handles it. The study will give single and multiple doses to 128 healthy volunteers and compare them to people who receive a placebo. The main goal is to …

This study aims to understand how a non-invasive brain stimulation technique called TMS affects brain activity in healthy people. Researchers will use MRI scans to watch brain changes while applying magnetic pulses to the forehead area. The knowledge gained could help design bett…

This study aims to understand how three new drugs are absorbed and processed by the body and to check their safety. It involves 36 healthy adult volunteers who will take the drugs after a meal. This is an early-stage trial to gather basic information before testing in patients wi…

This is the first study in humans for a new oral drug called AN2-502998. The main goal is to check if the drug is safe and to see how the body absorbs and processes it. The study will involve 72 healthy adults, who will receive either the drug or a placebo. Researchers will monit…

This study is testing a new, non-invasive brain stimulation technique called temporal interference (TI) on healthy volunteers. The goal is to see if TI can safely and precisely target deep brain areas without affecting the surface, using brain scans (fMRI) to measure its effects.…

This study aims to develop better tools for measuring what people eat by testing if stable isotopes in blood, hair, and fat can track sugar intake from soda. For 13 weeks, 60 healthy adults will live at the NIH and follow controlled diets with different amounts of soda. Researche…

This study aims to understand how the number of calories you eat changes the energy your body uses to digest and process food. Healthy volunteers will live in a clinic for about 35 days, eating controlled diets while researchers measure their metabolism in special rooms. The goal…

This study aims to understand how the body's natural process of breaking down and rebuilding proteins changes as we age. Researchers will enroll 75 healthy adults over age 20. Participants will drink safe, labeled water for three weeks and provide small tissue samples to measure …

This is an early safety study to see if a new drug called LIFE-001 is safe for healthy adults and how their bodies process it. Researchers will give increasing doses to small groups of volunteers and closely monitor for any side effects. The study will help determine if the drug …

This study aims to measure how much KarXT medication passes into breast milk when taken by healthy nursing mothers. Researchers will track medication levels in both breast milk and blood over time to understand potential infant exposure. The study involves 8 healthy lactating par…

This study is testing a new, very detailed camera system called adaptive optics to take pictures of the retina at the back of the eye. Researchers want to see if these super-clear images can help doctors find and understand eye diseases much earlier than is currently possible. Th…

This study is testing a new idea: that training your brain with a physical skill, like a motor task, might make it easier to learn a new language. Researchers are recruiting over 1,100 healthy French-speaking adults to see if the brain changes from motor training can boost langua…

This study aims to collect white blood cells from healthy volunteers to supply researchers studying the immune system and aging. Up to 10,000 participants will donate cells using a safe machine that separates and returns most of their blood. The goal is to provide high-quality ce…

This early-stage study aims to check if a new drug called ARGX-213 is safe for people. It will involve 80 healthy adults who will receive either the drug or a placebo. Researchers will track side effects and measure how the drug moves through the body over about 21 weeks.

This early-stage study aims to see if combining the psychedelic compound psilocybin with a supplement called D-Serine is safe for healthy people. Researchers will give the combination to 10 healthy volunteers to check for side effects and measure how it changes their thoughts, fe…

This study aims to develop better MRI scanning methods to see the heart and arteries in more detail without using radiation. Researchers will compare these new MRI techniques to standard heart tests in up to 4000 adults, including both healthy volunteers and people with or at ris…

This long-term study aims to understand why some children develop unhealthy eating patterns and weight gain by following 1,500 kids aged 8-17 for up to six years. Researchers will track factors like sleep, mood, genetics, and brain activity to see how they influence eating behavi…

This early-stage study aims to understand how the body processes new versions of the drug combination KarXT. It will involve 72 healthy adult volunteers to measure drug levels in the blood and check for safety. Researchers will compare new pill forms to existing ones and see if t…

This is an early safety study testing a new drug called BB-025, both by itself and after another drug called BB-031. The main goal is to see how safe these drugs are and how they move through the body in 72 healthy volunteers. Participants will be monitored for 28 days to check f…

This study aims to understand how HIV behaves in different body tissues, not just the blood. Researchers will collect small tissue samples from the tonsils, lymph nodes, intestines, and lungs of HIV-positive patients, patients with a rare immune condition (ICL), and healthy volun…

This early-stage study is testing whether a daily supplement containing a natural sugar from human milk can increase beneficial gut bacteria and improve markers linked to heart health. It will enroll 100 healthy adults who eat a typical Western diet. Participants will take the su…

This study is investigating whether suvorexant, a medication approved for sleep problems, can change brain chemistry related to addiction in people with alcohol use disorder (AUD). Researchers will compare brain scans, sleep patterns, and cravings in people with AUD receiving eit…

This early-stage study aims to understand how the body breaks down and eliminates the experimental drug E2086. Ten healthy male volunteers will receive a single, traceable dose. Researchers will measure how much of the drug is absorbed, how long it stays in the body, and how it i…

This study is testing whether a specific hands-on therapy for the muscles between the ribs can improve breathing strength and walking endurance in healthy young adults. Researchers will compare the technique against a fake treatment and no treatment in 90 participants aged 18-30 …

This study aims to understand how the body absorbs and processes Kaempferol, a natural substance found in many fruits and vegetables. Researchers will give Kaempferol to 120 healthy adults and measure its levels in blood and urine over time to learn about its safety and how it mo…

This study aims to understand how a person's genetic makeup affects how their body processes an experimental drug called KarXT. Researchers will enroll 56 healthy adults who have different genetic profiles related to drug metabolism. The main goal is to measure drug levels in the…

This early-stage study aims to understand how the body absorbs different tablet versions of an experimental drug called BMS-986435. It will also test if eating food affects how the chosen tablet works. The study involves 140 healthy adult volunteers to gather basic safety and abs…

This is the first study in humans to test the safety and drug levels of a new oral medication called BMS-986521. Healthy adult volunteers will take single and multiple doses to see how their bodies handle the drug and check for side effects. The study will also examine whether ta…

This study aims to gather basic information about how laser light interacts with different parts of the healthy human eye. Researchers will shine safe, low-power lasers into the eyes of 20 healthy volunteers and measure how the light reflects. The goal is to improve the safety an…

This study collects blood samples from healthy volunteers and people with HIV to support laboratory research on infectious diseases and immune function. Participants undergo a special blood collection procedure called apheresis, which allows researchers to obtain larger quantitie…

This is the first study in people for a new drug called VV261. Its main purpose is to check the safety and see how the body absorbs and eliminates the drug. The study will enroll 58 healthy volunteers in China who will receive a single dose of either the drug or a placebo. Resear…

This early-stage study aims to understand how the body processes and tolerates three new drug compounds (DWJ1622, DWC202313, and DWC202314). It will enroll 40 healthy adult volunteers to measure drug levels in the blood and check for side effects. The main goal is to gather basic…

This study aims to understand what happens in the brain when someone thinks about or attempts suicide. Researchers will compare brain scans, sleep patterns, and blood tests from people with different levels of suicidal thoughts to healthy volunteers. Some participants currently i…

This is an early safety study testing an experimental nasal spray called CHF6467 in 68 healthy adults. Researchers want to see if the spray is safe and how the body processes it, including whether it reaches the fluid around the brain and spinal cord. The study will test single d…