HEALTHY VOLUNTEERS

This early-stage study aimed to test the safety and immune response of a new investigational vaccine designed to protect against Meningitis B, a serious bacterial infection. It involved 576 healthy volunteers, including infants, toddlers, adolescents, and adults, comparing the ne…

This was the first study to test a new oral drug called ASP5502 in people. The main goal was to check its safety and how the body processes it. It involved healthy adults and people with primary Sjögren's syndrome, an autoimmune disease that causes severe dryness and fatigue. The…

This study aimed to discover proteins or other substances in blood and urine that appear when a person's kidneys are damaged but not when they are healthy. Researchers enrolled 226 adults and children, including healthy volunteers, people at risk for kidney failure, and those wit…

This study tested a new drug, PF-07258669, to see if it is safe and can help older adults who are losing weight without trying. The goal was to improve appetite and nutrition. It was a small, early-stage trial that was later stopped.

This study aimed to understand the safety and body's response to breathing low-oxygen air for an extended period. Six healthy volunteers stayed in a hospital setting for seven days, breathing air with reduced oxygen for five of those days. Researchers closely monitored their vita…

This early study aimed to develop a child-friendly liquid version of the antiviral drug maribavir. Researchers tested two powder formulas in 20 healthy adults to see how the body absorbs them compared to adult tablets, and to check their taste and safety. The goal was to gather i…

This early-stage study aimed to check the safety of a new drug called AMG 378 and see how the body absorbs and processes it. It involved 48 healthy adults who received either the drug or a placebo. The trial was terminated, meaning it was stopped early, and its main goal was to g…

This was the first human study of an experimental drug called iCP-NI, designed to block inflammation at the cellular level. Researchers tested single and multiple doses in 24 healthy adults to check for safety, side effects, and how the body processes the drug. The study was term…

This study aimed to develop new MRI hardware and software that uses safe, inhaled tracer gases to take pictures of lung function. The goal was to create clearer images without using harmful radiation, which could help doctors better understand lung health in the future. The study…

This study aimed to understand how mindfulness training might affect the brains of teenagers who vape nicotine. Researchers used brain scans to see if an app-based mindfulness program changed connections in brain areas linked to craving and self-control. They also checked if any …

This study aimed to understand why teens vape and how parents feel about it. Researchers surveyed over 700 teens and parents about vaping habits, mental health, and stress. The goal was to gather information to help address the rise in teen vaping, not to test a treatment.

This early-stage study aimed to test if a new radioactive tracer, used during PET scans, could create clearer pictures of inflammation in the body. It involved people with rheumatoid arthritis or inflammatory muscle diseases, as well as healthy volunteers. The goal was to see if …