HEALTHY VOLUNTEERS

This study tested whether a high-dose flu vaccine provides better protection for older adults than the standard-dose vaccine. Over 1,500 healthy volunteers aged 60 and older received either the high-dose or standard shot. Researchers measured the strength of the immune response a…

This study tested a booster vaccine for meningococcal disease in healthy toddlers aged 12 to 23 months. The children had already received their first meningococcal shots as babies. Researchers gave a single booster dose and checked the children's blood before and after to see how…

This study tested the safety and immune response of a new investigational vaccine designed to protect against five major groups (A, B, C, W, Y) of meningococcal bacteria, which can cause meningitis and bloodstream infections. It involved 1,215 healthy adolescents (10-17 years) an…

This study tested a new rabies vaccine (called VRVg-2) to see if it works as well as two already approved vaccines. It involved over 1,700 healthy children and adults in Thailand who received the vaccine before any potential exposure to rabies. Researchers measured the body's imm…

This study tested an experimental flu vaccine that contains an extra H3 influenza strain, in addition to the standard recommended strains. It involved 400 healthy adults in two age groups (18-49 and 60+) to check if the vaccine is safe and if it triggers a good immune response. T…

This study tested a new vaccine designed to protect infants and toddlers from four major strains of meningococcal disease, a serious bacterial infection that can cause meningitis. It involved over 1,500 healthy children in India and South Africa. Researchers compared the new vacc…

This study tested a new vaccine designed to protect against four types of meningococcal disease (A, C, W, Y) in healthy teenagers. Researchers compared the new vaccine to an already approved one to see if it worked just as well. They also checked if it was safe and effective when…

This study tested a new vaccine designed to protect against H7N9 influenza, a type of bird flu. Researchers compared two different strengths of the vaccine mixed with an immune-boosting ingredient (MF59) to the vaccine alone in 581 healthy adults. The main goal was to see which f…

This early-stage study tested the safety and immune response of new combination vaccines targeting multiple respiratory viruses. Healthy adults aged 18-49 received one injection of either a flu vaccine or a combined vaccine for RSV, hMPV, and parainfluenza. Researchers monitored …

This study tested a new vaccine designed to protect against two common respiratory viruses, RSV and human metapneumovirus (hMPV), in adults aged 60 and older. Researchers gave 646 healthy participants a single shot to check for safety and to see if it triggered a strong immune re…

This early-stage study tested the safety and immune response of a new mRNA-based flu vaccine in healthy adults. Researchers gave 233 participants different dose levels of the experimental vaccine and monitored them for side effects and antibody production for a year. The goal was…

This study tested several new versions of a flu vaccine to see how safe they were and if they could trigger a good immune response. It involved 210 healthy adults, split into groups receiving different formulas, some with an extra ingredient (adjuvant) to potentially boost effect…

This study tested the safety and immune response of a new oral vaccine designed to prevent diarrhoea caused by Shigella and ETEC bacteria. It involved 196 healthy Bangladeshi adults and children, starting with adults and then moving to younger age groups. Participants received th…

This study looked at whether it's safe and effective to give a high-dose flu shot and a Moderna COVID-19 booster shot at the same time to adults aged 65 and older. Researchers compared giving both shots together versus giving them separately. They measured side effects and how we…

This study tested if a high-dose flu shot given as a muscle injection works better than a standard-dose shot given under the skin for people aged 60 and older in Japan. It involved 2,100 healthy volunteers and measured their immune response and safety 28 days after vaccination. T…

This large, completed study tested whether a new two-dose vaccine could prevent dengue fever in healthy children and teenagers. Over 20,000 participants aged 4 to 16 received either the real vaccine or a placebo shot. Researchers tracked the children for years to see how well the…

This early-stage study tested the safety and immune response of a new mRNA vaccine designed to prevent serious lung infections caused by RSV and human metapneumovirus (hMPV). It involved 558 healthy adults, including people aged 60 and older, who received one of several different…

This study tested a new vaccine designed to prevent dengue fever. About 480 healthy children and adults in India received two shots of either the vaccine or a placebo (dummy shot) three months apart. The main goals were to check for side effects and see if the vaccine successfull…

This study tested a new vaccine designed to protect infants and toddlers from four types of serious meningococcal disease (A, C, W, and Y). It compared the new vaccine to an existing one to see if they worked equally well and were similarly safe. The study involved 840 healthy ba…

This study tested a single-dose vaccine designed to protect against four types of meningococcal disease (A, C, W, Y). It involved 447 healthy volunteers in Vietnam, aged 12 months and older, to see how well their immune systems responded and to check for side effects. Participant…

This early-stage study tested whether a new experimental vaccine for herpes simplex virus type 2 (HSV-2), which causes genital herpes, is safe for people. The trial involved 69 healthy adults, some with and some without prior herpes infections, who received three injections of ei…

This early-stage study tested whether a potential new medicine for sickle cell disease, called etavopivat, affects the heart's electrical activity. Researchers gave the drug at different doses to 33 healthy volunteers to check for safety, particularly looking at heart rhythm. The…

This study tested a new medication called Mim8, given as a weekly or monthly injection under the skin, to prevent bleeding episodes in people with severe hemophilia A. It involved 275 male participants, including those with and without inhibitors to standard treatments. The main …

This early-stage study checked how a new stomach acid drug (linaprazan glurate) interacts with a standard antibiotic combination used to treat H. pylori, a common stomach bacteria. It involved 56 healthy volunteers and people with the infection. Researchers measured drug levels i…

This was the first study in people to test the safety of a new drug called LAD191, which is being developed for autoimmune diseases. It involved 69 healthy volunteers and people with an autoimmune condition. The main goal was to see how safe different doses were and to understand…

This study tested how well a wearable motion sensor measures how high a person can jump. Researchers had 29 healthy women perform jumps while wearing the sensor and using a validated smartphone app at the same time. The goal was to see if the sensor's measurements matched the app…

This early-stage study is testing a new radioactive tracer called 18F-LNC1007 for PET/CT scans. The goal is to see how this tracer moves through the body, how much radiation it delivers, and if it's safe in a small group of 8 healthy volunteers and cancer patients with very small…

This study tested a new type of PET scan that uses a special tracer called [18F]APN-1607. The goal was to see if this scan could show different patterns in the brains of healthy people, people with mild memory problems, and people with Alzheimer's dementia. Researchers compared t…

This study aimed to improve the standard tuberculosis (TB) skin test. Researchers tested a new, easier-to-use needle and a non-invasive machine to read the results, hoping to make the test simpler and more consistent. The study involved 59 healthy volunteers to compare the new me…

This study tested whether replacing regular cookie ingredients with quinoa-based ones could help healthy people maintain better blood markers linked to obesity and metabolic syndrome. Sixty volunteers ate either regular cookies or quinoa-based cookies for 12 days each, with a bre…

This study tested whether a dietary supplement called Immulina could strengthen the body's natural defenses against flu viruses. Nearly 500 healthy adults took either Immulina or a placebo pill daily for 20 weeks. Researchers measured changes in key immune cells in the blood to s…

This study tested whether digital nutrition workshops could help hospital employees eat a more plant-based, sustainable diet. 64 healthy volunteers were randomly assigned to receive either an intensive online training program or basic digital information over 13 weeks. Researcher…

This study tested whether taking Rhodiola rosea (golden root) supplements for just 7 days could improve exercise performance and mental focus in adults who regularly lift weights. Twenty-seven participants tried different doses of the supplement, a placebo, and a no-pill period i…

This small pilot study explored whether a gentle movement practice called the Feldenkrais Method could help reduce stress and improve body fluid balance in healthy, sedentary women. Twenty-four women were split into two groups: one group attended eight daily movement sessions, wh…

This study aimed to find the safest and most effective moment to insert a camera tube into the stomach during a 'painless' exam. Researchers tested whether waiting for two specific signs from the patient—a relaxed jaw and a stable heart rate—was better than the usual single sign.…

This study tested whether a low dose of a medication used for ADHD (methylphenidate), when combined with 6 weeks of computerized brain training, could improve thinking skills and simulated driving performance in healthy older adults. The goal was to see if this combined approach …

This study tested if a short session of static neck stretching could lower blood pressure in healthy adults. Researchers measured blood pressure, tissue stiffness, and heart rate in 25 participants to see if stretching relaxes blood vessels. The goal was to see if this simple act…

This study tested whether adding a 12-week strength and power training program to regular dance practice improves movement quality, lower body strength, and overall performance in female college sports dancers. Thirty experienced dancers were randomly assigned to either do the ex…

This study tested whether walking in a green outdoor space helps people bounce back from mental tiredness and stress better than walking indoors. Researchers had 80 healthy young adults take a 30-minute walk, either outside in a forest park or inside on a treadmill in a plain roo…

This study measured how much nicotine enters the bloodstream when people use different products. It compared electronic cigarettes (both flavored and unflavored), a nicotine inhaler, and regular tobacco cigarettes. The goal was to understand how these products deliver nicotine to…

This study measured how well the body absorbs vitamin A when it's added to bouillon cubes, a potential strategy to combat vitamin A deficiency in low-income countries. Researchers compared absorption from three different fortified bouillon formulations against a standard oil-base…

This study aimed to understand how cooling the brain and the timing of brain stimulation affect brain activity. Healthy volunteers wore a cooling cap and received non-invasive magnetic brain stimulation while their brain waves and muscle responses were measured. The goal was to g…

This early-stage study aimed to check the safety and tolerability of a new injection called TAK-881 in healthy adults. The trial involved 64 healthy volunteers who received the injection under the skin to see how their bodies reacted. Researchers tested different dosing schedules…

This study aimed to understand how the body's endocannabinoid system, which is involved in appetite and mood, affects insulin production and action. Researchers tested two experimental drugs (nabilone and CP-945,598) in 45 healthy male volunteers to see how they changed insulin l…

This study aims to understand how healthy infants' brains and behaviors develop during their first year of life. Researchers will track 80 healthy babies at 3, 6, and 12 months using brain scans, brain wave measurements, and eye-tracking. The goal is to learn how early experience…

This study tested how an investigational cancer drug called repotrectinib affects the body's processing of several common medications. Researchers gave repotrectinib alongside drugs like metformin (for diabetes), digoxin (for heart conditions), and others to 30 healthy adult volu…

This study aimed to see if a new tablet form of a magnesium and vitamin B6 supplement (Magne-B6) gets into the bloodstream the same way as the existing liquid version. It involved 24 healthy adults who took both forms on separate occasions while fasting. Researchers measured the …

This study aimed to understand how short-term use of a steroid medication (hydrocortisone) affects memory and specific parts of the brain. Researchers gave 66 healthy adults and a small group with depression either the steroid or a placebo for three days. They used detailed brain…

This early study tested a new drug being developed for fatty liver disease. Researchers gave a single injection to 33 people, some with liver problems and some with healthy livers, to see how their bodies processed the drug and to check for side effects. The main goal was to unde…

This early study aimed to understand how two different versions of an experimental pill called BGB-43395 are absorbed by the body. It also tested whether eating food changes how the pill works. The study involved 51 healthy adult volunteers to gather this basic safety and absorpt…

This early-stage study tested how eating food affects the way the body absorbs an experimental prolonged-release drug called vamifeport. It involved 28 healthy adult volunteers who took the drug once with food and once without. The main goal was to measure drug levels in the bloo…

This was an early-stage study to check the safety of a new oral drug called ATH-399A, which is being developed to treat Parkinson's disease. Researchers gave the drug to 76 healthy adult volunteers to see how their bodies reacted to it and processed it, including whether taking i…

This study aimed to see if a new tablet version of an experimental drug called UCB0022 gets into the bloodstream as well as the original version. It involved 14 healthy adults who took each tablet form once, in a random order. The main goal was to measure and compare the drug lev…

This early-stage study tested a new drug called SAR441344 in healthy volunteers to see if it is safe and how the body handles it. The main goal was to check for side effects and measure drug levels in the blood over time. It was not designed to treat any specific disease.

This was an early-stage study to check the safety of a new drug called BMS-986419 in healthy people. Researchers gave the drug to 74 volunteers to see how their bodies handled it and to carefully measure if it had any effect on their heart rhythm. The main goal was to gather basi…

This study aimed to see if a new version of the drug dupilumab behaves the same way in the body as the current version. It involved 182 healthy adults who received a single injection of one of the two versions. Researchers then tracked the drug levels in the blood and monitored f…

This early study aimed to understand how a new drug called ITI-333 works in the brain. Researchers gave single doses to 12 healthy volunteers and used special brain scans to see how much of the drug attached to its target. They also checked how the body processed the drug and mon…

This study tested a new ultrasound method to see if it can measure blood flow inside bones. Researchers enrolled 30 healthy male volunteers to see how blood flow in the shin bone changes during simple physical tests, like squeezing a hand or having a blood pressure cuff inflated.…

This early-stage study tested how the body absorbs two different versions of the experimental drug centanafadine: a new sustained-release tablet and an existing extended-release capsule. The trial involved 62 healthy adult volunteers to measure and compare drug levels in the bloo…

This study tested how a new version of the common allergy medicine fexofenadine is absorbed by the body. Researchers compared the new tablet taken with or without water to the standard tablet taken with water. The goal was to see if the new formulation works similarly when taken …

This study aimed to understand how healthy adults' immune systems respond to seasonal and H1N1 (swine flu) vaccines. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination to measure immune changes. The goal was to gather detailed inform…

This study aimed to understand how the body processes a drug called risankizumab when it is injected using a new wearable device compared to a standard prefilled syringe. It involved 260 healthy volunteers who received the drug and were closely monitored. The main goal was to see…

This study aimed to understand how people with severe damage to both inner ears (bilateral vestibular hypofunction) use very fast, automatic eye movements to see clearly when they turn their heads. Researchers compared these quick eye movements in 12 patients with the condition t…

This is the first study testing a new drug called ORKA-001 in humans. It aims to check if the drug is safe and how the body handles it in 24 healthy volunteers. Participants receive a single injection, and researchers monitor for side effects and measure drug levels in the blood …

This was the first study in humans to test the safety and how the body processes the experimental drug VRG50635. It involved 22 healthy volunteers who received single or multiple doses. The main goals were to check for side effects and measure how the drug moves through and is el…

This early-stage study tested a new compound called AZD1163 in healthy volunteers to see if it's safe and how the body processes it. Researchers gave different doses to 108 participants, either through an IV or injection, and monitored them for side effects. The main goal was to …

This was the first study to test an experimental drug called TAK-004 in people. The main goal was to check its safety and see how the body processes it in 121 healthy adult volunteers. Participants received injections of either TAK-004 or a placebo, and researchers closely monito…

This study aimed to see how a new combination diabetes drug (HD-P023) compares to taking two separate diabetes drugs together. It involved 40 healthy adult volunteers to measure how the drugs move through the body and check for safety. The goal was to gather basic information to …

This study tested how a potential new schizophrenia medication (SEP-380135) might interact with other drugs in the body. Researchers gave healthy adult participants the study drug along with another medication that affects how drugs are processed. The goal was to understand poten…

This early-stage study aimed to understand the safety and how the body processes a new drug called ITI-333. It involved 32 healthy volunteers who received either the drug or a placebo daily for two weeks. The main goals were to check for side effects and measure how the drug move…

This early-stage study tested the safety of a single injection of a new experimental drug called NNC0581-0001. It involved 48 healthy adults and people with a fatty liver condition (hepatic steatosis) to see how their bodies reacted to the medicine. The main goal was to check for…

This early-stage study tested a new drug called KINE-101 in 24 healthy volunteers to see if it's safe and how it behaves in the body. Participants received daily intravenous doses for one week at three different strength levels, while some received a placebo. The main goal was to…

This study checked if a daily dietary supplement made from silver fir tree branches is safe for the liver and kidneys. Fifteen healthy adults took the supplement for two weeks. Researchers used blood tests to monitor for any negative effects on these vital organs.

This study aimed to improve epilepsy surgery by comparing different brain scanning methods. Researchers measured brain activity in 47 epilepsy patients and healthy volunteers using multiple techniques simultaneously. The goal was to better identify seizure-causing brain areas and…

This study aimed to understand how the drug belumosudil, used for immune system disorders, might interact with other medications in the body. It involved 52 healthy male volunteers who took belumosudil along with specific 'victim' drugs to measure their levels in the blood. The m…

This was an early-stage study to check the safety of a new experimental injection called GUB014295, which is designed to help with weight management. Researchers gave single and multiple doses to 76 healthy but overweight men and women to see how their bodies reacted. The main go…

This study aimed to understand how aging cells behave during wound healing. Researchers took small skin samples from healthy young adults (20-39) and older adults (70+) after creating minor wounds. The goal was to see if older cells respond differently, which could help future re…

This study aimed to understand how a new weight management drug, cagrilintide, is processed by the body. Researchers compared how people with different levels of liver function absorbed and cleared the drug after a single injection. The study also measured how the drug entered th…

This study aimed to understand how the body absorbs and processes the pain medication oxycodone when given as a nasal spray compared to a liquid taken by mouth. Eight healthy volunteers received both forms in a specific order to measure drug levels in their blood over time. The m…

This study aimed to understand how the healthy brain performs 'checking' processes, like verifying information or decisions. Researchers used brain scans (fMRI and EEG) on 51 healthy volunteers while they performed thinking tasks. The goal was to map which brain areas are involve…

This early-stage study tested a new drug called ALN-AGT01 RVR in healthy adults to see if it is safe and how it moves through the body. Forty-two participants received a single dose, and researchers closely monitored them for any side effects. The main goal was to gather initial …

This early-stage study tested how the body absorbs two different pill versions of an experimental drug called rilzabrutinib, which is being developed for autoimmune disorders. The study involved 28 healthy volunteers who took single doses of the pills, sometimes with food and som…

This early-stage study tested two different pill versions of an experimental drug combination for sickle cell disease. The goal was to see how the body absorbs a tablet versus a capsule. The study involved 44 healthy volunteers who took both versions in a random order to compare …

This study aimed to understand how genes might be linked to substance use disorders and related behaviors. Researchers collected genetic information and measured thinking skills, emotions, and decision-making in 847 adults, including healthy volunteers and people with substance u…

This study aimed to understand how two common medications (phenytoin and itraconazole) affect the way the body processes an experimental drug called BGB-16673. It involved 37 healthy adult volunteers who took BGB-16673 alone and then alongside the other medications. The main goal…

This early-stage study tested the safety of a new way to deliver two experimental antibodies into the body. Sixty-one healthy adults received injections followed by a mild electrical pulse to help the body produce the antibodies. The main goal was to see if this method was safe a…

This early study tested the safety of a new drug called BNC, which is being developed for Alzheimer's disease. Researchers gave single doses to 75 healthy volunteers aged 55 and older to see how their bodies processed the drug and to check for side effects. The study was designed…

This study looked at how holding leg muscle contractions at different knee angles affects balance, joint awareness, and physical performance in healthy people. Forty-four young adults completed an eight-week exercise program to see which knee positions worked best. The results co…

This study aimed to compare how two different powder formulations of the drug treprostinil are absorbed into the body when inhaled. It involved 42 healthy volunteers who each tried different strengths of the two inhaler versions. The main goal was to measure drug levels in the bl…

This was the first study in humans to test the safety and how the body processes a new drug called VNRX-7145. It involved 83 healthy adult volunteers who received either the drug or a placebo. The main goal was to see if the drug was safe and to measure how long it stayed in the …

This is a first-in-human study to check the safety and see how the body processes a new drug called SIM0278. It involved about 60 healthy volunteers in China who received injections of the drug or a placebo. The main goal was to find safe dose levels and understand how the drug m…

This study aimed to understand how our brains process different kinds of feedback, like social praise or monetary rewards, when we make decisions. Researchers worked with 76 healthy volunteers, using brain scans and a mild, safe ear stimulation technique to see which brain areas …

This early-stage study aimed to check the safety and see how the body processes a new injection made from a plant compound called Ginkgolide B. It involved 36 healthy Chinese adults who received either the injection or a placebo. The main goal was to monitor for side effects and …

This small pilot study explored whether combining motivational techniques with mental practice could improve lower back and hip strength in healthy people. Forty participants were split into groups to either imagine movements, watch movements, or do these activities with added mo…

This study tested a new, potentially cheaper version (MB04) of the arthritis drug Enbrel. It involved 141 healthy male volunteers who received single doses of the new drug and the original versions. Researchers compared how the drugs moved through the body and checked for safety …

This early-stage study tested the safety of an experimental drug called LAD603 in healthy adults. Researchers gave 92 participants single or multiple doses to check for side effects and see how the body absorbs and processes the medication. The main goal was to determine safe dos…

This study aimed to understand how a specific gene variation affects how the body processes cholesterol after eating. Researchers compared 100 healthy men with two different versions of this gene. They took blood samples before and after a test meal to see if the gene variation c…

This study tested new versions of a fast-acting insulin called insulin lispro in healthy volunteers. Researchers wanted to see how quickly the body absorbs and clears these new formulations from the blood and to check their safety. The study did not treat diabetes but gathered in…

This was the first study to give the new oral drug MT-501 to people. Its main purpose was to check if the drug is safe and to see how the body absorbs and processes it. The study involved 72 healthy adult volunteers who took single and repeated doses for up to 8 days. The results…

This early-stage study aimed to understand how two slightly different versions of the experimental drug amlitelimab are processed by the body and to check for side effects. It involved 32 healthy adult volunteers who received a single injection. The main goal was to compare how t…

This was a first-in-human study to check the safety and see how the body handles a new drug called AJ302-IM. It involved 57 healthy adult volunteers who received a single injection. The main goal was to find out if the drug was safe and to measure its levels in the blood and urin…

This study aimed to understand how two existing drugs—one for lung disease and one for diabetes—affect hormones that control blood sugar. Researchers tested the drugs on 29 healthy volunteers to see if they work together to boost helpful gut hormones. The goal was to gather basic…

This study used special brain scans (PET imaging) to look at a brain chemical called glutamate in adults with autism and Fragile-X Syndrome, comparing them to healthy volunteers. The goal was to better understand the biology of these conditions, not to test a treatment. It involv…

This was an early-stage study to check the safety of a new drug called BMS-986460 and see how it moves through the body. It involved 85 healthy adult male volunteers. The research tested different pill versions and measured side effects and drug levels in the blood.

This study measured how a single dose of the cancer drug repotrectinib behaves in people with moderate or severe liver impairment compared to healthy people. Researchers enrolled 18 adults to understand if liver problems change how the drug moves through the body. The goal was to…

This was an early-stage study to check the basic safety of a new drug called NAV-240 when given multiple times. It involved 24 healthy adults who received either the drug or a placebo (a dummy treatment). The main goal was to see what side effects might occur and to learn how the…

This study aimed to find out which flavors of a sore throat lozenge medicine taste best to people. 120 healthy volunteers (60 adults and 60 children) tried five different flavored lozenges, holding each in their mouth for 10 seconds before spitting it out. They then rated the tas…

This study aimed to measure and compare how much nicotine from different oral pouches actually gets into a person's bloodstream. It involved 27 healthy adults who regularly use nicotine pouches or snus. Participants tried four different products while researchers tracked nicotine…

This study aimed to find early warning signs in the blood for serious pregnancy complications like pre-eclampsia. Researchers measured specific proteins in 115 women across three groups: those with normal pregnancies, those with placental complications, and healthy non-pregnant v…

This completed early-stage study aimed to understand how the body processes a new drug called atumelnant and to check its safety in healthy people. It involved 21 healthy Japanese and Caucasian adults who received either the drug or a placebo. The main goals were to measure drug …

This early research study tested a single dose of an experimental drug called cenerimod in 20 healthy volunteers. The goal was to check its safety and see how the body absorbs and processes it. Researchers compared results between 10 Japanese and 10 Caucasian participants to look…

This study aimed to understand if digestion slows down during labor, which affects whether women should be allowed to eat. Researchers measured how quickly a light meal emptied from the stomach in four groups: women in labor with and without pain relief, pregnant women, and non-p…

This study aimed to see how two slightly different versions of an experimental pill are absorbed by the body. It involved 12 healthy adults who each took both pill versions. The main goal was to measure and compare the drug levels in the blood to help decide which version to use …

This study tested whether a drug called zilucoplan works the same way in the body when injected using a standard syringe versus a new auto-injector device. It involved 14 healthy adults who received the drug both ways. The main goal was to see if the auto-injector delivers the dr…

This was a first-in-human study to check the safety and how the body processes a new drug called Benfo-Oxythiamine (B-OT). The study involved 48 healthy male volunteers who took the drug as a capsule and were closely monitored. The goal was to gather basic safety data to see if t…

This study aimed to understand how our brains form and recall memories from realistic, everyday situations. Researchers had 95 healthy volunteers use smartphones in daily life or explore virtual reality environments to create memories. They then used brain scans and eye tracking …

This early-stage study aimed to understand how eating food and changing the pill's formulation affect how the body absorbs a drug called rilzabrutinib. It involved 24 healthy volunteers who took single doses under different conditions. The main goal was to gather basic safety and…

This early-stage study tested how a new drug called golcadomide behaves in people with moderate to severe liver problems compared to healthy volunteers. Researchers gave a single dose to 29 participants to measure drug levels in the blood and check for safety issues. The goal was…

This study aimed to understand why a common type of blood pressure medicine works better for some people than others. Researchers gave the drug enalapril to 21 healthy volunteers to see if differences in a specific liver gene affect how the body activates the medicine. The goal w…

This early-stage study aimed to understand how a drug called maribavir is processed by the body in healthy Japanese adults compared to healthy Caucasian adults. It involved 24 healthy volunteers and tested single oral doses. The main goal was to see if the drug's levels in the bl…

This study aimed to create a normal reference database showing how healthy children's leg muscles work while walking. Researchers measured muscle activity in 110 healthy kids aged 3-15 as they walked. The data will help doctors compare and identify abnormal walking patterns in ch…

This study aimed to understand how well different oxygen delivery methods work by measuring oxygen and carbon dioxide levels in the throat of healthy volunteers. Researchers tested high-flow oxygen through a nasal tube or face mask, and standard oxygen through a mask, while volun…

This early study tested a new medicine called etavopivat, which is being developed for sickle cell disease and thalassemia. It involved 24 healthy Chinese volunteers to see how their bodies process a single dose of the drug and to check for any side effects. The main goal was to …

This study tested whether a new, easier-to-use prefilled pen delivers the same amount of the drug risankizumab into the body as the standard prefilled syringe. It involved 59 healthy adult volunteers to measure drug levels, safety, and how the body processes it. The goal was to s…

This study aimed to understand how much of a medication called deucravacitinib, used to treat conditions like psoriasis, passes into breast milk. Researchers measured drug levels in the breast milk and blood of 8 healthy, lactating women after they took a single dose. The goal wa…

This study tested the safety of an experimental drug called AK1967 (Procizumab) in healthy men. The drug is being developed as a potential treatment for cardiogenic shock, a life-threatening heart condition. Researchers gave single doses to 24 healthy male volunteers to check for…

This study tested a new, simpler method for measuring how hard a person is working to breathe while using a non-invasive ventilator. Researchers compared this new method against the current, more complex 'gold standard' measurement in 12 healthy volunteers. The goal is to find an…

This early-stage study aimed to understand how the body absorbs, breaks down, and eliminates an experimental oral drug called SAR439859, which is being developed for breast cancer. Six healthy post-menopausal women received a single, very small dose containing a safe radioactive …

This early-stage study tested how the body absorbs different versions of the experimental drug povetacicept. It involved 136 healthy volunteers to compare two drug formulations and presentations. The main goal was to see if different forms of the drug behave similarly in the body…

This study aimed to understand why some people taking certain medications, like the antifungal drug voriconazole, develop a severe sunburn-like reaction to light. Researchers tested 62 participants, including healthy volunteers and patients on the medication, by exposing small pa…

This study aimed to understand how healthy people's bodies process and break down a combination of ten different drugs. Ten healthy volunteers took the drugs to help researchers map individual differences in drug metabolism. The goal was to gather basic safety data and learn how …

This study tested a new method using tiny needles to collect fluid from just under the skin. It involved 20 people, both healthy volunteers and those with atopic dermatitis (eczema). The goal was to see if this method works well and is comfortable, to help researchers better unde…

This study aimed to understand how weightlessness during spaceflight affects the body's smallest blood vessels (microcirculation). Researchers tested a non-invasive imaging technique on 16 healthy volunteers during short periods of weightlessness created by parabolic airplane fli…

This early-stage study aimed to understand how a single dose of the drug teprotumumab moves through the body and how safe it is. It involved 20 healthy Chinese volunteers who received either the drug or a placebo. The main goal was to gather basic safety and drug-level data, not …

This early-stage study tested a new combination of substances used for PET scans in 22 healthy volunteers. The main goal was to check if the injections were safe and to see how they traveled through and were eliminated from the body. Researchers also wanted to find the best dose …

This study tested whether injecting an experimental drug called KAI-9531 in the upper arm or thigh works as well as injecting it in the abdomen. Researchers enrolled 51 healthy volunteers with different body weights to compare how much drug gets into the bloodstream from differen…

This was an early-stage study to check the safety and see how the body processes a new drug called AG-181. It involved 88 healthy volunteers who took either the drug or a placebo. The main goal was to see if the drug was safe and to measure how much of it got into the bloodstream…

This study measured how much nicotine enters the bloodstream from five different disposable e-cigarettes compared to a person's regular cigarette. Researchers worked with 20 adult smokers to track nicotine levels and cravings over several hours. The goal was to gather data on how…

This study aimed to understand how brief periods of weightlessness during parabolic flight affect the brain and memory. Researchers tested 24 healthy volunteers to see if zero-gravity conditions changed brain structure, spatial thinking skills, and stress markers. The goal was to…

This early-stage study aimed to understand how a new drug called OPC-167832 is processed by the body. Eight healthy male volunteers took a single oral dose containing a tiny, safe amount of radioactive tracer. Researchers then measured how much of the drug was absorbed, how long …

This early-stage study tested a new radioactive tracer called 68Ga-LNC1007, which is used for PET scans to detect cancer. It involved 8 total participants, including both healthy adults and people with solid tumors, to see if the injection was safe and to measure how it traveled …

This was the first study to test a new drug called NRS 033 in people. The main goal was to check its safety and see how the body absorbs and processes it. The study involved 24 healthy adults who received a single dose and were closely monitored for side effects. This early resea…

This study collected blood samples from children (6 months to 9 years) and older adults (65+) after they received their annual flu vaccines. Researchers analyzed these samples to measure how well the body's immune system responded to the 2021-2022 vaccine formulas. The data helps…

This study aimed to understand how well the body absorbs two new dissolving tablet versions of the drug vonoprazan, which treats heartburn and stomach acid problems. Researchers compared these new forms—taken with or without water or via a syringe—to a standard tablet. The study …

This study tested a special type of MRI scan to see if it could reliably measure healthy hip cartilage. Researchers scanned 31 healthy volunteers twice in one session to check if the measurements were consistent. The goal is to gather baseline information that could help detect e…

This study aimed to understand how well the body absorbs collagen from supplements. Twenty-five healthy male volunteers drank different collagen solutions, and researchers took small blood samples over several hours to measure collagen components. The goal was to see which collag…

This study aimed to check if Moderna's updated COVID-19 booster vaccine affects levels of a protein in the blood that can indicate heart stress. Researchers enrolled 1,000 healthy participants aged 12 to 30 and measured this protein before and after vaccination, comparing results…

This study aimed to understand if giving growth hormone to healthy men could improve how their immune system works. Researchers enrolled 66 healthy men aged 25-50 and gave some of them growth hormone infusions via a small pump under the skin for several weeks, while others receiv…

This study aimed to understand how the body absorbs, breaks down, and eliminates the experimental drug venglustat. Six healthy male volunteers received a single, traceable dose. Researchers then measured how much of the drug and its byproducts were excreted in urine and feces ove…

This study aimed to understand how women's bodies absorb and use vitamin E, an important antioxidant. Researchers enrolled 50 women, including some who were obese or had diabetes, to measure how different amounts of dietary fat and vitamin C affect vitamin E levels in the blood a…

This study aimed to understand how meditation and hypnosis affect brain activity and our sense of self. Researchers used brain scans (fMRI) on 100 healthy volunteers while they practiced these techniques. The goal was to map which brain areas become active during these altered st…

This early-stage study tested how a new schizophrenia drug called KarXT interacts with three common mood medications (lithium, valproic acid, and lamotrigine). Researchers gave healthy volunteers different combinations of these drugs to see how they affect each other in the body.…

This study aimed to find a more accurate way to measure what people eat by testing substances in blood and hair. Researchers fed 59 healthy men specific diets for 12 weeks to see if these body samples could reliably show how much meat, fish, and soda they consumed. The goal was t…

This study aimed to understand how the brain learns to adjust our eye movements and process what we see. Researchers used MRI brain scans on 36 healthy volunteers while they performed simple eye-tracking tasks. The goal was to map which brain areas are involved in this learning p…

This study collected blood samples from 90 healthy children (6 months to 9 years) and seniors (65+) who received standard flu vaccines. Researchers took blood before and after vaccination to analyze immune responses. The samples were sent to major health agencies to help them des…

This study aimed to gather basic knowledge about veins in the shoulder area. Researchers used ultrasound on 50 healthy volunteers to see how raising and rotating the arm changes the size and position of specific veins. The goal was to collect detailed measurements to help doctors…

This study aimed to understand how the body absorbs and uses vitamin C. Researchers first put healthy young adults on a low vitamin C diet, then gradually gave them increasing doses, both by mouth and by injection. They closely measured vitamin C levels in the blood and urine to …

This was the first study to give a new drug called NNC0113-6856 to people. The main goal was to check its safety and see how the body absorbs and processes it. The study involved 70 healthy male volunteers who received either a single oral dose or an injection. Researchers measur…

This study aimed to understand how different types of light exposure affect feelings of tiredness and mental performance after a night without sleep. Researchers tested 18 healthy young adults to see if light could help counteract the effects of sleep loss. The goal was to gather…

This was a very early, small study to see if a new drug called EA5 is safe for people and to learn how it moves through the body. It involved 28 healthy adults who received a single dose. The main goal was to check for side effects and measure drug levels in the blood to help pla…

This early-stage study tested a single oral dose of a new drug called ENX-104 in 10 healthy volunteers. The main goals were to see if it was safe, how it moved through the body, and how much it attached to specific targets in the brain using PET scans. This type of study helps re…

This early-stage study tested the safety and heart effects of an experimental drug called BMS-986278 in healthy people. The two-part trial involved 42 healthy volunteers to check for side effects and see how the drug moves through the body. Researchers specifically measured if th…

This study tested a special 3D camera system to create detailed images of people's torsos. Researchers wanted to see if this safe, radiation-free method could accurately measure body shape in people with conditions like scoliosis or obesity, and in healthy volunteers. The goal wa…

This study aimed to understand the hidden complexity in simple hand-tapping movements. Researchers measured how 60 healthy volunteers performed a finger-tapping test. The goal was to gather basic knowledge that might one day help assess or monitor certain neurological conditions.

This early research study tested a single dose of an experimental drug called selatogrel in healthy people. The goal was to see how the drug moves through the body and what effects it has, comparing results between 16 Japanese and 16 Caucasian volunteers. This type of study is th…

This is the first study to test a new drug called KINE-101 in humans. It enrolled 40 healthy volunteers to check if the drug is safe and to see how the body absorbs and processes it. Participants received either the drug or a placebo (inactive substance) as a single injection or …

This was the first study in humans to test the safety and body's response to a new, experimental drug called NNC0582-0001. It involved 56 healthy adults who received a single injection under the skin, with some receiving the drug and others receiving a placebo. The main goal was …

This was a small, early-stage study to see how the body processes a new drug called TAK-123 and to check its safety. It involved 10 healthy Japanese men who received a single dose through an IV. The main goal was to gather basic information on how the drug moves through the body …

This was the first study in humans to test the safety of a new oral medicine called NNC0705-0001. The medicine is being developed to treat chronic inflammation, which increases the risk of heart and kidney disease. The study involved 116 healthy adults to see how safe the drug is…

This early-stage study tested how a single dose of an experimental drug, BMS-986278, is processed by the body in people with different levels of kidney function. It involved 27 participants, including healthy volunteers and people with severe kidney disease or kidney failure requ…

This early-stage study aimed to understand how two experimental antibiotics, ceftibuten and ledaborbactam, move from the blood into the lungs after people take them by mouth. Researchers gave the drugs to 34 healthy adults and collected samples from their blood and lung fluid to …

This study explored whether gently stimulating the brain with electricity during naps could improve specific sleep patterns linked to emotional health and stress resilience. Healthy adult volunteers who regularly nap wore a special cap to monitor brain activity while napping and …