HEALTHY VOLUNTEERS

This early-stage study tested an experimental mRNA vaccine designed to prevent lower respiratory tract disease caused by RSV and hMPV viruses. About 558 healthy adults aged 18-49 and 60+ received a single shot at different doses. Researchers monitored safety and immune responses …

This early-stage study tested a new mRNA-based flu vaccine in 233 healthy adults aged 18 and older. The goal was to check if the vaccine is safe and triggers an immune response. Participants received one shot at different dose levels, and researchers monitored side effects and an…

This study tested a new vaccine called ShigETEC in 196 healthy Bangladeshi adults and children. The vaccine aims to protect against two common causes of diarrhea: Shigella and ETEC. Researchers checked if the vaccine was safe and if it triggered an immune response. Participants r…

This study looked at whether a booster dose of the MenQuadfi vaccine is safe and effective for toddlers aged 12 to 23 months who had already received a meningitis vaccine as babies. The study involved 71 healthy toddlers in Argentina. Researchers measured the immune response befo…

This early-stage study tested whether a flu vaccine with an extra H3 virus strain is safe and triggers a strong immune response. About 400 healthy adults aged 18-49 and 60+ received either the experimental vaccine or a standard one. The goal was to see if adding another H3 strain…

This early-stage study tested the safety and immune response of new vaccines that combine protection against flu, RSV, hMPV, and PIV3. Healthy adults aged 18 to 49 received a single injection of one of several vaccine formulas. Researchers monitored side effects and measured anti…

This study tested a single dose of an investigational meningitis vaccine (MenACYW) in 447 healthy people aged 12 months and older in Vietnam. The goal was to see how well the vaccine triggered the body's defenses against four types of meningococcal bacteria and to check for any s…

This study tested a new vaccine called HSV529 to see if it is safe for people. The vaccine is designed to prevent genital herpes caused by the herpes simplex virus type 2 (HSV-2). A total of 69 healthy adults aged 18 to 40, some with and some without HSV infection, received eithe…

This study tested Takeda's dengue vaccine in 480 healthy people aged 4 to 60 in India. Participants received two doses of either the vaccine or a placebo, three months apart. The main goals were to check for side effects and measure the body's immune response to the vaccine.

This study tested a new vaccine that targets two respiratory viruses—RSV and hMPV—in adults aged 60 and older. The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either a single shot or a booster after 12 months, and researcher…

This study tested a dengue vaccine in over 20,000 healthy children aged 4 to 16. The goal was to see if two doses could prevent dengue fever caused by any of the four dengue virus types. The vaccine aims to protect children from this serious mosquito-borne disease.

This study tested a new meningitis vaccine (MenACYW) in 463 healthy adolescents aged 10 to 17. It compared the new vaccine to an existing one (Nimenrix®) and also looked at safety when given alongside HPV and Tdap-IPV vaccines. The goal was to see if the new vaccine provides simi…

This study tested several new versions of a quadrivalent (four-strain) flu vaccine in 210 healthy adults aged 18 and older. The goal was to see if the vaccines were safe and how well they triggered the immune system to produce antibodies against influenza. Some formulas included …

This study tested an experimental RSV vaccine in about 4,500 adults aged 60 and older. Half received the vaccine and half received a placebo. The goal was to see if the vaccine could prevent lower respiratory tract disease caused by RSV, a common virus that can be serious in olde…

This study tested a new meningitis vaccine (MenACYW) in healthy infants and toddlers aged 6 to 12 months. The goal was to see if it works as well as an existing vaccine (Nimenrix) when given as two shots. The trial involved 840 participants and measured immune response and safety…

This study tested two different doses of an experimental H7 bird flu vaccine, each combined with an immune booster (MF59), against a version without the booster. About 581 healthy adults aged 18 and older took part. The goal was to see which dose produced the strongest immune res…

This study looked at whether it's safe and effective to give a high-dose flu vaccine and a Moderna COVID-19 booster at the same time to adults aged 65 and older. Participants had already received two doses of the Moderna COVID-19 vaccine at least five months earlier. The goal was…

This study tested a new vaccine to protect infants and toddlers against four types of meningococcal bacteria that can cause meningitis. Over 1,500 healthy children in India and South Africa received the vaccine alongside their routine shots. Researchers checked if the vaccine tri…

This study tested an experimental vaccine designed to protect against five strains of meningococcal bacteria (A, B, C, W, Y), which can cause serious infections like meningitis. About 1,200 healthy adolescents and young adults received the vaccine to check its safety and how well…

This study tested whether a daily oral supplement called Immulina can help healthy people fight off upper respiratory viruses like the flu. Researchers measured natural killer cell activity and other immune markers in 492 adults aged 18-59 and 65+. The goal was to see if the supp…

This study tested a new medicine called Mim8 in 275 people with hemophilia A, some of whom had developed inhibitors that make standard treatment less effective. Mim8 is injected under the skin weekly or monthly to replace the missing clotting factor and prevent bleeding episodes.…

This early-phase trial tested a new radioactive imaging agent called 18F-LNC1007 in 8 people—some healthy and some with a small number of cancer lesions. The goal was to see how the agent moves through the body, how much radiation it gives off, and whether it is safe. Participant…

This early-phase trial tested the safety of a new imaging agent called 68Ga-LNC1007 in 8 adults—some healthy and some with solid tumors. Participants received a single injection and were monitored for side effects and how the agent moved through the body. The goal was to see if i…

This study tested a new imaging agent called [18F]APN-1607 to see if it can help diagnose Alzheimer's disease by detecting specific brain changes. About 230 people took part, including those with Alzheimer's, mild cognitive impairment, and healthy volunteers. The goal was to comp…

This study tested two new tools to make tuberculosis (TB) skin tests better. Researchers compared a new, easy-to-use needle against the standard method and tried a non-invasive scanner to read the results. The goal was to see if these tools could make TB testing simpler and more …

This study tested a new rabies vaccine (VRVg) in 1,708 healthy children and adults in Thailand. The goal was to see if it works as well as current vaccines in preventing rabies before exposure. Participants received up to three doses, and some got a booster shot later to check lo…

This study tested a high-dose flu vaccine in 1,539 healthy adults aged 60 and older. The goal was to see if the high-dose shot triggers a stronger immune response than the standard-dose flu shot. Results showed that the high-dose vaccine produced higher antibody levels against al…

This study tested whether replacing certain ingredients in cookies with quinoa could help healthy adults maintain normal blood fat and sugar levels, potentially lowering the risk of obesity and metabolic syndrome. Sixty healthy volunteers ate either a regular cookie or a quinoa-b…

This study tested whether a high-dose flu vaccine (QIV-HD) works better than the standard-dose vaccine (QIV-SD) in adults aged 60 and older. About 2,100 healthy volunteers in Japan received one of the two vaccines. The goal was to see if the high-dose version triggers a stronger …

This study tested seven different cosmetic creams to see if they could prevent skin darkening caused by high-energy visible light (like from the sun or screens). Thirty-three healthy adults with light to medium skin tones had creams applied to their back before being exposed to a…

This pilot study tested whether the Feldenkrais Method, a gentle movement and awareness practice, could reduce stress and improve well-being in 24 healthy, sedentary women aged 26-59. Participants did eight daily 90-minute sessions or were in a control group. Researchers measured…

This study looked at 342 healthy adults having a painless stomach scope (gastroscopy). Doctors tested different times for giving a combination of two sedative drugs to see which timing caused the fewest side effects like coughing, movement, or drops in blood pressure. The goal is…

This study looked at whether taking certain food supplements daily for 3 months can improve skin firmness, elasticity, and radiance in healthy women aged 40 to 60. A total of 132 women took either one of three supplements or a placebo. Researchers measured skin properties like fi…

This study tested whether a low dose of methylphenidate (a drug used for ADHD) combined with computer-based cognitive training could improve thinking skills in healthy older adults. Thirty-one volunteers without memory problems took part in the 6-week program. The goal was to see…

This study tested whether TRPTI (oleoylethanolamide) helps healthy adults process sugar better. Nineteen participants took either 150 mg, 300 mg, or a placebo in random order. Researchers measured blood sugar and insulin levels after a sugary drink to see if TRPTI improves glucos…

This study looked at whether taking Rhodiola rosea (golden root) for a week can help resistance-trained adults lift more and think sharper. Twenty-seven healthy men and women tried low and high doses, a placebo, and a no-pill control. They did strength tests, a cycling sprint, an…

This study collected blood samples from 90 healthy children (6 months to under 9 years) and adults 65 and older who received the 2020-2021 flu vaccine. The samples were sent to health experts to help decide which flu strains to include in future vaccines. The goal was to support …

This study looked at how a single dose of repotrectinib stays in the blood of people with moderate or severe liver impairment compared to healthy volunteers. 18 adults took part to help understand if liver function changes drug levels. The results will guide dosing for patients w…

This study looked at whether taking a nap in different settings helps healthy adults stay alert and drive better. Forty good sleepers aged 20 to 50 did driving tests and alertness checks after napping or resting. Researchers measured things like driving errors, sleepiness, and he…

This study tested two different versions of an inhaled drug (TPIP) in 42 healthy adults to see how well each is absorbed by the body. Participants inhaled a single dose of each version on separate days. The goal was to gather information for future development, not to treat any d…

This study looked at how taking ZN-A-1041 tablets with food or a stomach-acid drug (rabeprazole) changes the amount of medicine in the blood. Twenty-four healthy adults took the drug under different conditions to measure absorption. The goal was to gather information for future d…

This early-stage study tested the safety of a new drug called VNRX-7145 in 83 healthy adults aged 18 to 45. Participants received either a single dose or multiple doses over 10 days to see how the drug moves through the body and if it causes any side effects. The goal was not to …

This study collected tissue samples from tonsils, lymph nodes, intestines, and lungs of people with HIV and healthy volunteers. The goal was to measure the amount of virus and immune cells in these tissues. It helps researchers understand how HIV behaves in the body, but did not …

This study looked at how a drug called quinidine changes the way the body processes SEP-380135, a potential schizophrenia treatment. Twelve healthy adults took a single dose of SEP-380135 with and without quinidine to measure drug levels and safety. The goal was to understand pos…

This study tested how well vitamin A is absorbed from fortified bouillon (broth) compared to an oil-based supplement. Fifty-eight healthy women ate different vitamin A formulations in bouillon and had blood samples taken to measure absorption. The goal is to see if adding vitamin…

This study looked at how cooling the brain changes its activity in healthy adults. Participants wore a cooling cap while researchers used transcranial magnetic stimulation (TMS) and EEG to measure brain responses. The goal was to understand brain plasticity, not to treat any dise…

This pilot study tested whether adding motivation to mental imagery or action observation could improve lower back strength in healthy adults. Forty participants were split into four groups: some did mental imagery, some watched actions, and half of each group also received extra…

This study looked at how people with alcohol use disorder process social and alcohol-related images in their brains. Researchers used MRI scans and a technique called neurofeedback to see if people could learn to control their brain activity. The goal was to better understand the…

This study looked at how a cancer drug called repotrectinib changes the way the body processes other medications. Thirty healthy adults took a mix of common drugs (like metformin and omeprazole) with and without repotrectinib to see if levels of those drugs changed. The goal was …

This early-stage study tested the safety of a new drug called KINE-101 in 24 healthy adults. Participants received daily intravenous doses for a week at different strength levels. The goal was to see if the drug is safe and how the body processes it, not to treat any disease.

This study followed 80 healthy infants from 3 to 12 months old to see how their brains and behaviors change. Researchers used brain scans, EEG, and eye tracking to measure development. The goal was to understand normal growth patterns, not to test a treatment.

This study looked at how a drug called KAI-9531 enters the body when injected into the upper arm, thigh, or abdomen. It involved 51 healthy volunteers with different body sizes. The goal was to see if the injection site changes how much drug gets into the bloodstream.

This study tested whether two different injection devices deliver the same amount of the drug amlitelimab into the body. It involved 212 healthy adults aged 18-55 who received a single dose under the skin. The main goal was to compare drug levels in the blood and check for any sa…

This early-stage study tested a new drug called Benfo-Oxythiamine (B-OT) in 48 healthy male volunteers to see if it is safe and how the body processes it. Researchers are exploring B-OT as a potential treatment for infectious diseases and cancer. Participants took the drug as cap…

This study looked at how different types of feedback (like social or monetary) affect decision-making in healthy adults. Researchers used brain scans and a mild stimulation technique to understand which brain areas are involved. The goal is to apply this knowledge to help people …

This study used a special 3D camera system (stereophotogrammetry) to take pictures of people's torsos without any radiation. Researchers aimed to better understand body shapes in people with scoliosis, chest wall deformities, obesity, and healthy volunteers. About 199 participant…

This study looked at how mindfulness meditation and hypnosis affect the brain and our sense of self. One hundred healthy adults underwent brain scans while doing tasks and reporting their experiences. The goal was to understand the brain areas involved in self-awareness during th…

This study looked at whether being in labour affects how fast the stomach empties a light meal. Researchers used ultrasound to measure digestion in 43 women: some in labour with or without epidural, some pregnant, and some not pregnant. The goal is to help guide safe eating recom…

This study looked at 50 healthy adults to see if changing arm position makes veins in the armpit and collarbone area easier to see on ultrasound. Researchers measured the visible surface of these veins with the arm by the side versus raised and rotated. The goal is to help doctor…

This study looked at how different types of light affect tiredness and thinking skills in 18 healthy adults after staying awake all night. Researchers measured fatigue, hormone levels, and mental performance. The goal was to learn more about sleep loss, not to test a treatment.

This study gave 6 healthy men a single dose of venglustat with a tiny radioactive marker to see how the drug is absorbed, broken down, and eliminated. Researchers measured radioactivity in blood, urine, and stool to understand the drug's path through the body. The goal was to lea…

This study looked at how healthy adults perform simple tapping tasks to measure the complexity of their movements. Researchers used special math tools to analyze these movements, aiming to find patterns that might one day help diagnose or treat movement disorders. The study invol…

This study involved 120 healthy volunteers (60 adults and 60 children) who tasted five different flavors of benzydamine HCl lozenges. They held each lozenge in their mouth for 10 seconds without swallowing, then rated its taste, aftertaste, and texture using a simple questionnair…

This study tested two different oral forms (a tablet and a capsule) of an experimental medicine called NDec in 44 healthy adults. NDec is being developed for sickle cell disease, but this trial did not treat the disease—it only measured how the body absorbs the drug from each ver…

This study looked at whether giving growth hormone can improve how the immune system works in healthy men aged 25 to 50. Participants received either growth hormone or a placebo through a small pump under the skin. The goal was to see if the hormone could reverse age-related immu…

This study tested a new version of the allergy drug fexofenadine (Allegra) to see how well it is absorbed when taken with or without water, compared to the current coated tablet taken with water. Twenty-five healthy adults each received six different treatments in random order un…

This study tested a single dose of a new drug called ORKA-001 in 24 healthy adults aged 18 to 65. The main goal was to check if the drug is safe and how the body processes it. No treatment for any disease was being tested—just basic safety information.

This study looked at how much nicotine gets into the body and how strong the urge to smoke is when using blu disposable e-cigarettes compared to regular cigarettes. Twenty adult smokers who smoke at least 10 cigarettes a day took part. Researchers measured nicotine levels in the …

This early-stage study tested a new drug called TAK-004 in 121 healthy adults to see if it is safe and how the body processes it. Participants received either TAK-004 or a placebo as an injection under the skin. The study focused on side effects, heart rate, blood pressure, and i…

This study looked at how the body handles a single dose of the experimental drug BMS-986278 in people with severe kidney problems or those on dialysis, compared to healthy volunteers. The goal was to understand safety and drug levels, not to treat the disease. 27 adults took part…

This study looked at how isometric exercises (holding a muscle tight without moving) for the front and back thigh muscles at different knee angles affect balance, body awareness, and daily movements like climbing stairs. Thirty healthy adults aged 20-30 did an 8-week training pro…

This study looked at how vitamin E is absorbed and used by women who are normal weight, overweight, or have type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after giving different doses and meals. The goal was to learn more about vitamin E needs in wome…

This study looked at whether giving the drug zilucoplan by a prefilled syringe or an auto-injector leads to similar levels in the blood. It involved 14 healthy adults aged 18 to 55. The goal was to check if both methods work the same, not to treat any disease.

This early-stage study tested a new drug called VRG50635 in 22 healthy adults aged 19 to 55. The main goals were to see if the drug is safe and how the body absorbs it. Participants took the drug and were monitored for side effects and drug levels in the blood.

This early-stage study tested the safety and tolerability of a new drug called LAD603 in 92 healthy adults aged 18 to 65. Participants received either the drug or a placebo to check for side effects and how the drug moves through the body. The goal was not to treat any disease, b…

This early-stage study tested the safety and tolerability of an experimental oral drug called AN2-502998 in 72 healthy adults aged 18 to 55. Participants received either the drug or a placebo to monitor side effects and how the drug moves through the body. The goal was to gather …

This study collected blood samples from 90 healthy children (6 months to under 9 years) and older adults (65+) after they received their regular flu shots. The samples were sent to health agencies to help decide which flu strains to include in future vaccines. No new treatment or…

This study tested how well risankizumab enters the body when given by a prefilled pen compared to a traditional syringe. It involved 59 healthy adults and measured drug levels, side effects, and immune response. The goal was to see if the pen works as well as the syringe, which c…

This study tested whether mild electrical stimulation to the brain during naps can increase certain sleep-related brain waves and improve emotional well-being. 72 healthy adults who nap regularly took part. Researchers measured brain activity, mood, and alertness to see if the st…

This early-stage study tested a new oral drug, ATH-399A, in 76 healthy adults to see if it is safe and how the body processes it. The goal is to gather information needed to develop a treatment for Parkinson's disease. Participants took single or multiple doses, and researchers a…

This study looked at whether an mRNA COVID-19 vaccine causes a rise in a heart enzyme called troponin, which can signal heart stress. About 1,000 healthy volunteers aged 12 to 30 received either the vaccine or a placebo. Researchers measured troponin levels before and after vacci…

This study tested whether a new biosimilar drug (MB04) behaves like the approved drug Enbrel® in the body. 141 healthy male volunteers received a single dose of either MB04 or Enbrel® (from Europe or the US). Researchers measured drug levels in the blood and checked for side effe…

This study looked at whether taking creatine and L-arginine together, just once, can improve short bursts of exercise and mental reaction time in healthy, active men. Eighteen men tried each supplement alone, together, or a placebo in random order. Results measured sprint power, …

This early-stage study looked at how healthy adults absorb and tolerate several new versions of insulin lispro, a fast-acting insulin. 54 volunteers participated in one of two parts to measure insulin levels in the blood and check for side effects. The goal was to gather safety a…

This study tested a new ultrasound method to measure blood flow inside the shin bone of 30 healthy men. The goal was to see if the technique can detect changes in bone blood flow during simple activities like squeezing a handgrip or having a blood pressure cuff inflated. This is …

This study looked at how a 12-week strength and power training program affects movement patterns, leg strength, and dance performance in Chinese college sports dancers. Thirty healthy female dancers with at least one year of experience took part. Half did strength training three …

This early-stage study tested the safety and tolerability of Ginkgolide B injection in 36 healthy Chinese adults aged 18 to 45. Participants received single or multiple doses to see how the drug moves through the body and whether it causes side effects. No treatment for any disea…

This study looked at how a drug called SAR439859, being tested for breast cancer, is absorbed, broken down, and removed from the body. Six healthy postmenopausal women took a single dose with a radioactive tracer. The goal was to understand the drug's metabolism and bioavailabili…

This study looked at how 10 different drugs are broken down in the bodies of 10 healthy volunteers. Researchers measured drug levels in the blood to create individual metabolic profiles. The goal was to better understand how people process medications, not to treat any disease.

This study looked at how two drugs—Roflumilast (used for COPD) and Sitagliptin (used for diabetes)—affect blood sugar and gut hormones in 29 healthy adults aged 21-55. Participants took the drugs or placebos and had their blood tested after a meal. The goal was to understand how …

This study looked at how a single injection of the experimental drug NNC0194-0499 behaves in the body of people with various degrees of liver impairment and in healthy volunteers. The drug is being developed for fatty liver disease (NAFLD/NASH). 33 adults received one shot, and r…

This early-stage study tested the safety and tolerability of a new drug called GUB014295 in 76 healthy adults who were lean, overweight, or obese. Participants received either the drug or a placebo as a single or multiple doses under the skin. The main goal was to check for side …

This early-stage study tested two different versions of an experimental drug called amlitelimab in 32 healthy adults. The goal was to see how the body processes each version and whether they are safe and well-tolerated. Participants received a single injection and were monitored …

This early-stage study tested a new tablet (HD-P023) against two common diabetes drugs taken together (teneligliptin and empagliflozin) in 40 healthy volunteers. The goal was to see how the body processes each drug and check for safety. No treatment was given for any disease; the…

This study looked at how the drug maribavir is absorbed and processed in healthy adults of Japanese descent compared to non-Hispanic Caucasian adults. It also tested three different doses in Japanese participants to see if the drug levels in the blood change proportionally with d…

This study looked at how well a non-invasive ventilation (breathing support) machine can measure a person's breathing effort. Twelve healthy adults took part to see if a simple test on the machine matches a more invasive measurement. The goal is to better understand and prevent l…

This early-stage study tested a new medicine called NNC0581-0001 in 48 adults to see if it is safe and how the body handles it. Some participants were healthy, and others had fatty liver (hepatic steatosis). Each person received either one injection of the drug or a placebo. The …

This early-stage study tested a single dose of an experimental drug called BNC in 75 healthy volunteers aged 55 and older. The goal was to see if the drug is safe and how the body processes it, as a first step toward possibly treating Alzheimer's disease. Participants took either…

This study tested whether online nutrition workshops could help hospital employees eat a more plant-based diet. 64 healthy adults working at a hospital took part. One group got intensive digital training (about 2 hours per week), while the other got lighter support (about 30 minu…

This early-stage study looked at how two drugs, epaminurad and C2406, affect each other in the body. 18 healthy adults took the drugs separately and together to check safety and drug levels. The goal was to gather information, not to treat any disease.

This study looked at how a single dose of a radioactive drug called OPC-167832 leaves the body. Eight healthy men took the drug, and researchers measured how much came out in their urine and stool. The goal was simply to understand the drug's journey, not to treat any disease.

This early-stage study tested a single dose of the experimental drug ENX-104 in 10 healthy volunteers. Researchers used PET scans to see how much of the drug attached to certain brain receptors and checked for side effects. The goal was to gather safety and dosing information, no…

This early-stage study tested the safety and how the body handles a new drug called ITI-333. It involved 32 healthy adults aged 18 to 45 who took either the drug or a placebo daily for 14 days. The goal was to check for side effects and measure drug levels in the blood, not to tr…

This study tested two different versions of an experimental drug called PF-07976016 in 12 healthy adults. The goal was to see how much of the drug gets into the blood after a single dose. Participants took both forms at different times so the amounts could be compared. This study…

This study tested a new device called E-celsius, which is a pill you swallow that measures your body temperature as it travels through your digestive system. It compared the pill's readings to standard temperature probes placed in the esophagus and rectum. The goal was to see if …

This completed study looked at how a new drug called KarXT interacts with three common mood-stabilizing medications (lithium, valproic acid, and lamotrigine) in 133 healthy adults. The goal was to measure how these drugs affect each other's levels in the blood and to check for an…

This study looked at whether the experimental drug EB-1020 could be abused, like other stimulants. It involved 80 healthy adults who occasionally use stimulants for fun. Researchers gave them single doses of EB-1020, a placebo (dummy pill), or d-amphetamine (a known stimulant) an…

This study looked at how the painkiller oxycodone behaves in the body when given as a nasal spray versus an oral solution. Eight healthy adults took a single dose of each form on separate days. The goal was to collect data to improve computer models that predict how drugs reach t…

This early-stage study tested the safety and how the body handles two experimental antibodies (AZD5396 and AZD8076) in 61 healthy adults aged 18-60. Participants received injections followed by a mild electrical pulse to help the body produce the antibodies. The goal was to check…

This study looked at how different oxygen delivery methods affect oxygen and carbon dioxide levels in the throat of 14 healthy volunteers. The goal was to understand why high-flow oxygen therapy works better for some COVID-19 patients. The findings could help improve oxygen treat…

This early-stage study tested a new drug called NRS 033 in 24 healthy adults aged 18 to 55. The main goal was to check the drug's safety and how the body processes it, not to treat any disease. Participants received either a single dose of NRS 033 or a placebo, and researchers mo…

This study tested how well the drug risankizumab enters the body when given through a wearable injector compared to a standard syringe. It involved 260 healthy adults and measured drug levels in the blood and any side effects. The goal was to see if the new device works as well a…

This early-stage study tested the safety of multiple doses of an experimental drug called NAV-240 in 24 healthy adults aged 18 to 65. Participants received either NAV-240 or a placebo to see what medical problems, if any, occurred. The goal was to gather initial safety informatio…

This early-stage study tested the safety and how the body processes a single dose of ALN-AGT01 RVR in 42 healthy adults. Participants received either the drug or a placebo, and researchers monitored for side effects and drug levels in blood and urine. The goal was to gather initi…

This study looked at how the drug golcadomide behaves in people with moderate or severe liver problems compared to healthy volunteers. 29 adults received a single dose to measure drug levels and check for side effects. The goal is to find safe dosing for patients with liver impai…

This study tested whether a non-invasive imaging technique could capture changes in tiny blood vessels during brief periods of weightlessness on parabolic flights. Sixteen healthy volunteers were observed during 21-second weightless intervals. The goal was to better understand ho…

This study aimed to understand how the immune system responds to seasonal and H1N1 flu vaccines in healthy adults. Researchers collected blood and nasal samples from 203 NIH employees before and after vaccination. The goal was to analyze immune responses to improve future vaccine…

This study looked at how different versions of an experimental drug, BMS-986460, are absorbed by the body. It involved 85 healthy adult men to check safety and drug levels. The goal was to find the best formulation for future studies.

This early-stage study tested a single dose of an experimental drug called ENX-104 in 12 healthy adults. The goal was to see how the drug moves through the body when given as a liquid or a tablet, and whether a high-fat meal changes its absorption. No treatment for any disease wa…

This early-stage study tested a single dose of the experimental drug selonabant in 40 healthy adults aged 18 to 30. The main goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a placebo by IV, and researchers monitored si…

This study tested a new tablet form of Magne-B6 (magnesium and vitamin B6) against the current liquid version in 24 healthy adults. The goal was to see how well the body absorbs the new tablet. Participants took both forms at different times, and researchers measured magnesium an…

This study measured how much nicotine gets into the blood from an e-cigarette, a nicotine inhalator, and a regular cigarette. Twelve healthy smokers each tried all three products. The goal was to understand the nicotine levels each device delivers, not to treat any disease.

This study looked at how genetic differences affect the way the body activates a common blood pressure medication called enalapril. Healthy volunteers with and without a specific gene variant (G143E) were compared. The goal was to understand why some people respond better to trea…

This study tested a drug called belumosudil in 52 healthy men to see how it affects the body's ability to process other medications. The goal was to understand potential interactions, not to treat any disease. Results will help doctors use this drug more safely in the future.

This study looked at how taking vamifeport with or without food changes the amount of drug in the blood. It involved 28 healthy adults aged 18 to 60. The goal was to understand the drug's absorption, not to treat any disease.

This study looked at how nicotine is absorbed from different oral nicotine pouches in 27 healthy adults who regularly use snus or nicotine pouches. Participants tried four different products over a short stay in the clinic, and researchers measured nicotine levels in their blood.…

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and the hippocampus, a brain region key for learning. Sixty-six healthy adults and people with depression took either the drug or a placebo for three days. Researchers used memory tests and…

This study looked at how a new drug called linaprazan glurate interacts with common antibiotics (clarithromycin and amoxicillin) and bismuth in healthy volunteers and people with H. pylori infection. The goal was to measure drug levels in the blood and see how the body processes …

This study looked at how much of the drug deucravacitinib gets into breast milk and blood after a single dose in healthy women who are breastfeeding. Eight participants provided milk and blood samples over time. The goal was to understand potential infant exposure, not to treat a…

This study looked at how the brain controls and adjusts quick eye movements called saccades, which help us see and interact with the world. Thirty-six healthy adults performed eye-tracking tasks inside an MRI scanner so researchers could see which brain areas were active. The goa…

This early-stage study tested a new experimental drug, NNC0113-6856, in 70 healthy men to see if it is safe and how it moves through the body. Participants received either a single oral dose or an injection into the vein. The goal was to gather initial safety data and measure dru…

This early-stage study tested a new drug called SIM0278 in 60 healthy Chinese adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a single or multiple injections. The goal was to check for side effects and measure drug …

This study looked at how the body handles cagrilintide, a drug being developed for weight management, in people with different levels of liver function. It also measured how well the drug is absorbed when injected under the skin versus into a vein. The study involved 32 adults an…

This study looked at how two drugs that affect the body's endocannabinoid system (which helps regulate appetite and mood) influence insulin production and action. 45 healthy men aged 21-55 took part. The goal was to better understand insulin regulation, which could lead to new tr…

This early-phase study tested the safety and how the body processes TAK-123 in 10 healthy Japanese men aged 20 to 45. Participants received a single intravenous dose, and researchers measured drug levels and side effects. The study was completed and provides basic safety data, bu…

This study looked at how a tablet form of the experimental drug ABBV-722 moves through the body in 11 healthy adults. Researchers measured drug levels in the blood and checked if taking it with food changes absorption. The goal was to gather basic safety and processing informatio…

This study tested a new tablet that combines two cancer drugs, zanubrutinib and sonrotoclax, in 24 healthy adults. The goal was to see how well the body absorbs the combination tablet compared to taking the drugs separately, and whether food changes absorption. No treatment was g…

This study tested a special MRI technique called T1rho to measure hip cartilage in 31 healthy volunteers. The goal was to see if the method gives consistent results and to establish normal values. This could help doctors detect early signs of hip osteoarthritis before symptoms ap…

This study tested a non-invasive device that gently stimulates a nerve in the ear (vagus nerve) in 44 healthy adults. Researchers measured changes in brain waves and pain response during a single 60-minute session. The goal was to understand how this stimulation works, not to tre…

This study checked whether etavopivat, a new medicine for sickle cell disease, changes the heart's electrical activity. Thirty-three healthy adults received different doses of the drug, a placebo, or a standard heart medication. The goal was to see if the drug causes any heart rh…

This study looked at how eating too much at different times of day affects inflammation and metabolism in healthy adults. Sixteen volunteers were observed to see if evening overeating is worse than daytime overeating. The goal was to better understand the body's response to overe…

This study looked at how genes influence addiction and thinking skills like memory and decision-making. Researchers collected blood samples and had 847 adults (healthy volunteers, smokers, and people with substance use or other psychiatric disorders) complete questionnaires and c…

This study tested a single 16 mg dose of selatogrel in 32 healthy adults (16 Japanese, 16 Caucasian) to see how the body absorbs and breaks down the drug, and whether it causes side effects. Participants stayed in a clinic for 3-4 days and had follow-up visits. The study is compl…

This study looked at certain proteins (histones and HMGB1) in the blood of 115 pregnant women, some with complications like pre-eclampsia and some with healthy pregnancies. The goal was to see if these proteins could serve as early markers for placental problems. The research did…

This study checked if a wearable motion sensor (BTS G-sensor) can accurately measure how high people jump. Twenty-nine healthy women aged 18-35 did jump tests while wearing the sensor and also being measured by a smartphone app that is already known to work well. The goal was to …

This early-stage study tested the safety and how the body processes a new drug called BB-025, which is designed to reverse the effects of another drug (BB-031). 72 healthy adults received either BB-025 or a placebo, alone or after BB-031, and were monitored for 28 days. The goal …

This study looked at how two different tablet forms of BGB-43395 are absorbed by the body and whether food changes that. 51 healthy adults took a single dose of the drug. The goal was to gather information, not to treat any disease.

This early-stage study tested the safety and tolerability of a drug called BMS-986278 in 42 healthy adults. Researchers also checked if the drug affects the heart's electrical activity. The goal was to gather safety information, not to treat any disease.

This completed study tested a new device that collects fluid from the nose to find biological markers for respiratory diseases like COPD, asthma, hayfever, and sinusitis. Researchers compared 111 adults—both healthy volunteers and those with these conditions—to see if nasal bioma…

This study looked at the long-term safety of tafenoquine, a drug used to prevent malaria. 600 healthy volunteers took either tafenoquine or a placebo daily for 3 days, then weekly for 51 weeks. The main focus was on any serious eye problems, and participants were followed for ove…

This study looked at how different versions of the drug povetacicept are absorbed by the body in 136 healthy adults. The goal was to compare the drug's bioavailability and check that different forms of the drug work the same way. Researchers also monitored safety and side effects…

This study is for research only and does not treat any disease. It tests how safe a single dose of cenerimod is and how the body processes it in 20 healthy adults (10 Japanese, 10 Caucasian). Participants stay in the clinic for 4 days and have follow-up visits over about 75 days.

This early-stage study tested the safety of a new drug called ARGX-213 in 88 healthy adults. Researchers measured how the drug moves through the body and checked for side effects. Participants were monitored for up to 21 weeks. This study does not aim to treat any disease.

This early-stage study tested the safety of a new drug called LAD191 in 69 adults—some healthy and some with an autoimmune disease. Researchers measured side effects, how the drug moves through the body, and whether it triggers an immune response. The goal was not to treat the di…

This study tested whether a short session of neck stretching can lower blood pressure in 25 healthy adults. Researchers measured blood pressure, tissue stiffness, and heart rate before and after stretching. The goal was to see if stretching relaxes blood vessels and helps the bod…

This study used a special brain scan (PET imaging) to measure how a chemical called glutamate works in the brains of 27 men with autism, Fragile-X syndrome, or no condition. The goal was to better understand brain activity differences, not to test a treatment. Participants were a…

This early-phase study tested the safety and how the body processes a new drug called SEP-631 in 120 healthy adults aged 18 to 60. Participants received either the drug or a placebo to check for side effects and measure drug levels in the blood. The goal was to gather safety info…

This early-stage study tested the safety and how the body processes a new drug called atumelnant in 21 healthy adults (Japanese and Caucasian). Participants received either the drug or a placebo. The goal was to measure drug levels and check for side effects, not to treat any dis…

This early-stage study tested a single dose of EA5 in 28 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive EA5 or a placebo, and no one knew which they got. The goal was to check for side effects and measure drug lev…

This study tested the safety of a dietary supplement made from silver fir branches in 15 healthy adults aged 37-55. Participants took 900 mg daily for 14 days, and researchers measured liver and kidney function through blood tests. The goal was to see if the supplement caused any…

This study tested the safety and how the body processes a new drug called BMS-986419 in 74 healthy adults. Part 1 looked at side effects and drug levels, while Part 2 checked if the drug affects the heart's electrical activity. No treatment or cure is involved—the goal is simply …

This study looked at how two antibiotics, ceftibuten and ledaborbactam, travel through the body and into the lungs. Thirty-four healthy adults took the drugs and had one bronchoscopy to collect lung fluid samples. The goal was to measure drug levels, not to treat any disease.

This early-stage study tested a new oral medicine, NNC0705-0001, in 116 healthy adults to see if it is safe and how the body handles it. The medicine is being developed to treat chronic inflammation, which can lead to heart and metabolic diseases. Participants received either the…

This study looked at how the drug teprotumumab behaves in the body of healthy Chinese adults after a single intravenous dose. Twenty participants were enrolled to measure drug levels and check for side effects. The goal was to gather safety and dosing information, not to treat an…

This study looked at how many people are needed to find as many user mistakes as possible when using the Zeneo® medical device. 60 healthy volunteers, some with knowledge of auto-injectors and some without, took part. The goal was to improve device safety by understanding how the…

This early-stage study tested a single injection of a new drug, NNC0582-0001, in 56 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo and were monitored for a year. The goal was to gather safety data, not to trea…

This study looked at how brief periods of weightlessness during parabolic flights affect spatial memory and brain structure in 24 healthy adults. Participants completed computer-based spatial tasks and had brain scans before and after flying. The goal was to understand how the hi…

This early-stage study tested a new oral drug, MT-501, in 72 healthy adults aged 19 to 55. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects and changes in lab…

This early-stage study tested a single injection of a new drug, AJ302-IM, in 57 healthy adults to see if it is safe and how the body processes it. Participants were randomly assigned to receive either the drug or a placebo. The goal was to check for side effects and measure drug …

This study looked at how collagen from drinks gets into the blood. Twenty-five healthy men drank different collagen products or a placebo. Blood samples were taken over four hours to measure collagen building blocks. The goal was to understand absorption, not to treat any disease…

This study looks at why some medicines, like the antifungal drug voriconazole, can cause an extreme sunburn-like reaction called phototoxicity. Researchers will measure gene activity in the skin and blood of 62 people, including those taking voriconazole and healthy volunteers. T…

This study looked at how the amount of water a person drinks affects the level of vitamin C in their blood. Healthy adults aged 18-35 followed a low-vitamin C diet and then received increasing doses of vitamin C by mouth and through an IV. Researchers collected blood and urine sa…

This study looked at how the brain manages the process of checking our own actions, a skill that is often disrupted in people with obsessive-compulsive disorder (OCD). Researchers used brain scans (fMRI and EEG) on 51 healthy adults while they performed tasks that required checki…

This study tested a new microneedle patch that collects fluid from the skin in 20 adults—some healthy, some with eczema. The goal was to see how much fluid could be collected and how well people tolerated the procedure. This early-stage research aims to improve how we study skin …

This study looked at how aging skin cells (senescent cells) appear around small wounds in healthy adults. Researchers compared younger people (ages 20-39) with older adults (70+) to see if there are differences in wound healing. The goal is to better understand aging and age-rela…

This study looked at 12 people with chronic bilateral vestibular hypofunction (a balance disorder causing blurry vision during head movement) and 12 healthy volunteers. Researchers measured how quickly and often the eyes make tiny, automatic saccades during head turns to see if t…

This study looked at how taking a drug called rilzabrutinib with or without food, and in different pill forms, changes its levels in the blood. 24 healthy adults each took a single dose under different conditions. The goal was to gather information for future dosing, not to treat…

This study tested how well two different tablet forms of the drug rilzabrutinib are absorbed by the body, and whether food changes that absorption. 28 healthy adults aged 18-55 took single doses of each tablet form in random order. The goal was to gather information, not to treat…

This study looked at how a common seizure drug, carbamazepine, changes the amount of mirdametinib in the blood. 36 healthy adults took both drugs to see how the body processes them together. The goal was to understand potential drug interactions, not to treat any disease.

This study looked at how two different versions of the drug centanafadine are absorbed by the body. 62 healthy adults took either a sustained-release tablet or a once-daily extended-release capsule. The goal was to see which form delivers the drug more effectively, which can help…

This study tested a new imaging agent (GEH200521) in 22 healthy volunteers to see if it is safe and how it spreads in the body. The goal was to gather information for future disease detection, not to treat any condition. Participants received the agent and were monitored for side…

This study tested whether a new version of the drug dupilumab works the same as the current version in healthy adults aged 18 to 65. Participants received a single injection of either the new or current drug, and researchers measured drug levels in the blood and checked for side …

This study collected walking data from 110 healthy children aged 3 to 15 to create a reference database of normal gait patterns. Researchers placed sticky electrodes on leg muscles and recorded kids walking 10 meters five times. The goal is to help doctors better identify abnorma…

This early-stage study tested a new drug called AZD1163 in 108 healthy volunteers to see if it is safe and how the body processes it. Participants received either the drug or a placebo by injection or IV. The goal was to check for side effects and measure drug levels in the blood…

This study looked for better ways to measure what people eat by checking for natural markers in blood and hair. Fifty-nine healthy men ate carefully controlled diets for 12 weeks while researchers tracked changes in these markers. The goal was to see if these markers could reliab…

This study looked at how brain scans (fMRI and MEG) relate to electrical signals recorded directly from the brain (intracranial EEG) in people with epilepsy and healthy volunteers. The goal was to better identify the area causing seizures and map healthy brain networks to avoid d…

This study looked at how two common drugs—phenytoin and itraconazole—change the way the body processes BGB-16673. It involved 37 healthy adults aged 18 to 65. The goal was to measure drug levels in the blood, not to treat any disease.

This early-stage study tested a single dose of the experimental drug ITI-333 in 12 healthy adults aged 18-45. Researchers used PET brain scans to see how much of the drug attached to a specific brain receptor (5-HT2A) and checked safety and drug levels in the blood. The goal was …

This early-stage study tested the safety and tolerability of a new drug, SAR441344, in 56 healthy adults. Participants received either the drug or a placebo through an IV or injection. The main goal was to see if the drug caused any side effects, not to treat any disease.

This study looked at whether L-lysine, a common amino acid, can change levels of the hormones aldosterone and cortisol in healthy men. Twenty volunteers took L-lysine or a placebo for 13 days, then switched. The goal was to learn how the body controls these hormones, not to treat…

This study looked at two new dissolvable forms of vonoprazan (a stomach acid reducer) to see how well the body absorbs them compared to the regular tablet. Twenty-five healthy adults took single doses of each form, some without water and some mixed with water given by syringe. Th…

This study looked at whether a 30-minute walk outside in a green area helps people recover from mental tiredness and stress better than walking on a treadmill indoors. Researchers split 80 healthy young adults into two groups: one walked outdoors in nature, the other walked on a …

This study looked at how a small difference in a gene called CETP affects the way 'good' cholesterol (HDL) works in the body. Researchers compared two groups of healthy men—those with one version of the gene versus another—to see how well their HDL could remove cholesterol from c…

This study tested how well healthy adults tolerate a new medicine called TAK-881, given as an injection under the skin. 64 healthy volunteers aged 18-50 received one or more doses to check for side effects and how the body processes the drug. The goal was to see if the injection …

This study looked at how healthy people remember everyday events using smartphones or virtual reality. Researchers measured brain activity with fMRI to understand which parts of the brain are involved in recalling memories. The goal was to learn more about memory and attention, n…

This early-phase study tested a new antibody called AK1967 (Procizumab) in 24 healthy men to see if it is safe and how the body processes it. The antibody targets a protein that may worsen heart shock. This is a first step before testing it in patients with heart problems.

This study tested two different tablet versions of a drug called UCB0022 in 14 healthy adults aged 18 to 55. The goal was to see how much of the drug gets into the blood and if one tablet works better than the other. Researchers also checked for any side effects. This is an early…

This early-stage study tested the safety and tolerability of a new drug called AG-181 in 88 healthy adults. Participants received either the drug or a placebo, and researchers monitored side effects and how the drug was processed in the body. The study also looked at whether food…

This early-stage study tested a new drug called KINE-101 in 40 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a single dose through an IV or injection. The study is complete and provides important safety in…

This early-stage study tested a single dose of a new oral medicine called etavopivat in 24 healthy Chinese volunteers. The main goal was to see how the drug moves through and is processed by the body (pharmacokinetics) and to check its initial safety and tolerability. The results…