Berry lozenges tested as cancer shield in healthy volunteers
NCT ID NCT01961869
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tested whether black raspberry confections (like lozenges) could help prevent oral cancer. Sixty-seven healthy volunteers ate different versions of the confection to see which was most acceptable and how it affected genes and chemicals linked to cancer. The goal was to find the best way to deliver black raspberry's cancer-fighting compounds.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- black raspberry confection (lyophilized black raspberry powder)
- What this could lead to
- If successful, this could point toward a simple dietary approach to help prevent oral cancer in healthy people.
- What could go wrong
- This is a very early Phase 1 study in healthy volunteers, not patients. It focuses on taste, safety, and biological markers, not on actually preventing cancer. The results may not lead to any proven prevention method.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
-
67 people
The number who actually took part.
- Started
-
Jul 2013
- Finished
-
May 2014
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Be healthy, free-living adults * Be a non-smoker (defined as adults who have never smoked or who have not had a cigarette in the past ten years) * Agree to consume a standardized vitamin/mineral supplement and avoid other nutrition and alternative supplements for the duration of the study * Agree to follow a berry-restricted diet and to document any accidental consumption of restricted foods each day of the study * Agree to abstain from mouthwashes Exclusion Criteria: * Have an active metabolic or digestive illness including malabsorptive disorders, renal insufficiency, hepatic insufficiency, cachexia, or short bowel syndrome * Have an active or a recent history of any condition that causes altered immunity such as chronic inflammatory disease, autoimmune disorders, cancer, anemia, and blood dyscrasias * Have a known allergy or food intolerance to ingredients in study products (black raspberries),other berries, wheat, or soy * Are strict vegans (no consumption of animal, fish or egg products) * Are planning to conceive, or are currently pregnant or lactating * Are heavy alcohol consumers (defined as an average consumption of greater than 2 drinks/day) * Have a history of oral cancer or currently undergoing treatment of oral cancer * In the last month have had any active oral lesions or maladies or currently have any oral disease or obvious open sores in the oral cavity or surrounding the oral opening * Have strong gag reflex or problems swallowing that prohibit buccal brushing of the oral cavity * Have been on an antibiotic regime lasting for one week in the last 6 months
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Healthy volunteers are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
Columbus, Ohio, 43210, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Scientists probe the nerve highways behind strength gains
- New syphilis test kits put to the test with donated blood
- Can a copy of a blockbuster arthritis drug match the original? scientists test it in healthy people
- Novo nordisk tests Brand-New molecule in humans for the first time
- New sedative candidate goes Head-to-Head with propofol in early human test
- Can a Room-Temperature dairy drink build muscle?