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Scientists probe the nerve highways behind strength gains

NCT ID NCT07831382

NEW Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers are studying how the nervous system adapts when healthy adults strengthen their calf muscles. Twenty-two participants aged 18 to 40 complete a four-week resistance training program for the triceps surae, the main calf muscle group. Before and after training, researchers measure nerve pathway activity using magnetic and electrical stimulation to see how the brain and spinal cord contribute to strength gains.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A four-week resistance training program for the calf muscles
What this could lead to
If researchers map how nerve pathways change with strength training, it could sharpen how rehab and training programs are designed for people recovering from injury or managing nerve conditions.
What could go wrong
This is a small study of 22 healthy young adults, so its findings may not apply to older people, athletes, or patients. The magnetic stimulation used in testing can be uncomfortable and carries a small risk of seizure in susceptible people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 22 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Aug 2029

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female participants aged 18 to 40 years * Willing and able to provide written informed consent * No regular participation (\>1 session per week) in resistance training aimed at increasing maximal strength * Affiliated with, or beneficiary of, a social security system Exclusion Criteria: * Personal or family history of epilepsy * Conditions associated with a significantly reduced seizure threshold, including sleep deprivation, extreme fatigue, or jet lag * Use of medications or substances known to lower the seizure threshold * Use of medications that may influence neurophysiological measures (e.g., neuroleptics, anxiolytics, antidepressants, anticonvulsants) * Presence of cardiac pacemakers or other implanted devices that may interfere with magnetic fields * Presence of metallic implants (mechanical or electronic), including cochlear implants, cranial implants, cardiac or neural stimulators, drug infusion pumps, magnetic aneurysm clips, or cerebrospinal fluid shunts * Presence of non-removable metallic objects * Presence of intraocular or intracranial metallic foreign bodies * Known hearing disorders (e.g., tinnitus) * History of psychiatric or neurological disorders * Presence of severe cardiac or respiratory disease * History of severe traumatic brain injury with loss of consciousness * History of brain lesions of vascular, tumoral, infectious, or metabolic origin (e.g., stroke) * History or presence of bleeding disorders (e.g., venous or arterial thrombosis, thrombophlebitis) * Individuals currently under an exclusion period from another research study * Individuals listed under Articles L.1121-5 to L.1121-8 and L.1121-12 of the French Public Health Code, including: * Pregnant, parturient, or breastfeeding women * Women of childbearing potential not using effective contraception * Individuals deprived of liberty by judicial or administrative decision * Adults under legal protection (guardianship, curatorship, or legal safeguard) or unable to provide consent and not under such protection * Minors

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteers Neuromuscular adaptations Resistance training adaptation

How to take part

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  1. The official record

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