Institut National De La Santé Et De La Recherche Médicale, France

This study is testing whether gentle vibrations applied to leg muscles can help improve movement and walking in people recovering from a stroke or similar brain injury. Researchers will compare real vibrations to fake (sham) vibrations in 56 participants to see if the treatment h…

This study aims to understand how arteries naturally stiffen and age over more than a decade, and how that relates to future heart disease. Researchers are re-examining 7,500 healthy volunteers 12-16 years after their first check-up, using detailed ultrasound scans to measure cha…

This study aims to create better tools for diagnosing and choosing treatments for children with rare autoimmune and inflammatory diseases. Researchers will analyze blood and tissue samples from 500 children to find molecular patterns linked to their conditions. The goal is to pre…

This study aims to understand how epileptic seizures start and how the brain works during normal activities like sleep and thinking. Researchers will record brain activity using tiny electrodes already implanted in patients with drug-resistant epilepsy who are being evaluated for…

This research aims to understand the basic science of how humans feel touch. By studying healthy volunteers and some amputees, researchers will measure nerve signals in response to different textures and temperatures. The goal is to use this knowledge to build prosthetic limbs th…

This study aims to understand how the psychological trauma from the November 2015 Paris terrorist attacks is passed from parents to their children. Researchers are recruiting 960 people, including families directly affected by the attacks and families who were not exposed, to ser…

This study aims to better understand a group of rare eye defects present at birth, such as anophthalmia and microphthalmia. Researchers will follow 800 children and adults for up to 10 years to track how vision and development change over time and to identify genetic links. The g…

This study aims to discover why people with the same genetic mutation for a rare muscle and heart disease (laminopathy) can have very different symptoms and disease progression. Researchers will collect small tissue samples from 40 patients in France who have an LMNA gene mutatio…

This study aims to create a large international database to understand how Alport syndrome progresses over time in 700 patients. Researchers will track kidney function, hearing loss, eye problems, and quality of life to learn what factors predict kidney failure. The goal is to ga…

This study aims to test and improve the settings for MRI scans on a machine used only for research. Healthy volunteers and some patients will have scans to help researchers find the best settings for clear, high-quality brain images. The goal is to create better tools for future …

This study aims to create a detailed European registry of 400 people with cystinosis, a rare genetic disease where crystals damage organs. Researchers will collect health information over time to understand how the disease progresses and identify ways to improve patient care. The…

This study aims to find physical markers in the brain and body that can help doctors tell the difference between tics (from Tourette's) and compulsive behaviors (from OCD). Researchers will use portable EEG brain scans and smartwatches to record 50 participants both in a lab and …

This study aims to understand how the brain's ability to judge time changes as people get older. Researchers will recruit 130 healthy adults, both young and older, to perform time-judgment tasks while their brain activity is measured using EEG, MRI, and PET scans. The goal is to …

This French research study aims to understand how people with schizophrenia or bipolar disorder experience the flow of time differently. Researchers will use virtual reality games and brain wave recordings (EEG) to measure time perception in 120 participants, including patients a…

This French study aims to better understand a group of rare genetic conditions called imprinting disorders by tracking 2,000 patients over time. Researchers will observe patients' health patterns to identify common metabolic risks like diabetes or heart disease. The goal is to ga…

This study aims to understand if having asthma increases a person's risk of developing heart disease. Researchers are following up with 1000 people, some with asthma and some without, who were first studied 30 years ago. They will check for early signs of heart risk through healt…

This 10-year French study aims to better understand rare, progressive lung scarring diseases by tracking 3,000 patients and their family members over time. Researchers will collect detailed health information through regular check-ups, scans, and questionnaires to identify patter…

This study is testing a new, painless brain imaging technique called functional ultrasound (fUS) in newborns. It aims to see if this scan can help doctors understand early brain development and spot potential signs of future developmental disorders, like autism or learning diffic…

This study aims to gather detailed health information from 1000 French patients with a group of rare genetic disorders called Mucopolysaccharidosis (MPS). Researchers will look back at past medical records and follow patients forward to understand how these diseases naturally pro…

This study aims to understand why some women recover from anorexia nervosa after hospital treatment while others relapse. Researchers will follow 125 women with anorexia and 100 healthy women, using brain scans, blood tests, and psychological tasks to measure changes during and a…

This study aims to find biological markers that could help doctors diagnose ALS much earlier, before major symptoms appear. Researchers will compare blood, urine, and spinal fluid from 60 people, including those with a genetic risk but no symptoms, early ALS patients, and healthy…

This study aims to measure the full burden—including physical, emotional, social, and financial impacts—of living with nine rare skin diseases. Researchers will enroll 900 patients and their families across France to complete detailed surveys about their daily lives and healthcar…

This study aims to collect blood and tissue samples from 800 patients with various chronic liver diseases and liver cancer. Researchers will use these samples to create better laboratory models, like mini-tumors in dishes and mice, to study how these diseases progress and to test…

This study aims to understand what goes wrong in the immune system to cause chronic gut diseases like celiac disease and inflammatory bowel disease. Researchers will analyze blood and tissue samples from 200 adult participants to learn how immune cells become dysfunctional. The g…

This study aims to understand how a concussion before age 6 might affect a child's developing brain. Researchers will use brain scans to compare 30 children who had a concussion with 30 children who had a minor arm or leg injury. The goal is to see if there are differences in bra…

This study aims to create detailed reference images of what healthy hearts and livers look like at different ages and between sexes. Researchers will use MRI and ultrasound scans on 2,400 healthy French adults to establish normal ranges for heart function, liver fat, and body fat…

This study aims to better understand Primary Ciliary Dyskinesia (PCD), a rare genetic lung disease. Researchers will observe 300 patients to identify what factors predict more severe illness and how different gene changes affect a person's symptoms and quality of life. The goal i…

This study aims to better understand how Fabry disease affects heart rhythms over time. Researchers will implant small heart monitors in 40 male patients with Fabry disease and track their heart activity for three years. The goal is to identify patterns and connections between he…

This French study aims to understand how immune cells called macrophages behave differently in people with ALS compared to healthy individuals and people with other movement disorders. Researchers will analyze blood samples from 180 participants to identify potential new drug tar…

This study aims to understand how specific weaknesses in a person's immune system affect their long-term health. Researchers will follow 500 adults in France who have either a genetic defect or self-made antibodies that weaken a key antiviral defense. The goal is to see if these …

This study aims to see if measuring how stiff a person's arteries are can help doctors figure out if patients with resistant high blood pressure are actually taking their prescribed medications. Researchers will enroll 60 adults with this hard-to-control condition. They will use …

This study aims to understand how damage to the brain causes problems with thinking, memory, reading, or perception. Researchers will use detailed brain scans and other tests on 1,500 adults who have brain injuries and some healthy volunteers. The goal is to map how specific brai…

This study aims to discover the unknown genetic causes behind rare autoinflammatory diseases, where patients experience recurring fevers and inflammation. Researchers will analyze genes and blood samples from 300 patients to identify disease patterns and pathways. The goal is to …

This French study aims to create an online database to better understand how specific genetic changes affect people with intellectual disability and autism spectrum disorders. Researchers are recruiting 1,000 family members of affected individuals to complete questionnaires about…

This early-stage study aims to test the safety of giving high doses of the antiviral drug favipiravir to healthy volunteers for 14 days. Researchers will closely monitor participants for side effects and measure how the drug moves through and is processed by the body, including i…

This study aims to understand if a mother's stress, anxiety, or depression during pregnancy affects how her child's brain develops during the first year of life. It will follow about 87 families in France where the baby was diagnosed before birth with a serious heart defect requi…

This study aims to learn more about Still's disease, a rare inflammatory condition that causes high fevers, joint pain, and rashes in both children and adults. Researchers will follow 500 patients over time to compare how the disease affects different age groups, identify possibl…

This study aims to understand the genetic factors involved in autism spectrum disorder. Researchers will analyze blood samples from 3,800 participants, including people with autism and their family members, to look for patterns in specific brain-related genes. The goal is to map …