Could a simple nerve block ease debilitating Post-Stroke pain?
NCT ID NCT06446960
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether numbing a nerve in the arm or leg can reduce the severe, hard-to-treat pain some people feel after a stroke. Researchers will give 36 adults either one of two numbing medicines or a saltwater injection, then measure pain changes. The goal is to see if blocking signals from the body's nerves can help when standard painkillers fail.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 36 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2024
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients aged 18 years and over with no maximum age (blocks are generally very well tolerated in the very elderly) 2. Pain in the upper or lower limb distal enough to be completely covered by a peripheral nerve block 3. Chronic pain for at least 6 months 4. Ischaemic or haemorrhagic stroke for at least 6 months documented clinically and by appropriate imaging (MRI) 5. Post-stroke central neuropathic pain defined as pain occurring in the aftermath of stroke meeting the criteria for probable or defined neuropathic pain according to the NeuPSIG algorithm and with a DN4 screening questionnaire score of at least 4 out of 10. 6. Spontaneous pain intensity greater than or equal to 4 out of 10 on an 11-point numerical scale (EN) at inclusion and randomisation (i.e. just before each block) 7. Patients affiliated to a social security scheme or beneficiaries of such a scheme 8. Stable oral analgesic pharmacological treatment for at least 2 weeks prior to inclusion 9. Acceptance and signing of the informed consent Exclusion Criteria: 1. Inability or unwillingness to sign an informed consent 2. Person subject to a legal protection measure (safeguard of justice, curatorship, guardianship) 3. Patients with ongoing psychiatric pathology (major depression, psychosis) or cognitive disorders that prevent a good understanding of the protocol and questionnaires 4. Pain that is too widespread in one hemicycle or limb and cannot be adequately covered by blocks 5. Ongoing drug or substance abuse 6. Language (aphasia) or comprehension disorders, illiteracy 7. Moderate to severe renal or hepatic impairment 8. Contraindication to local anaesthetics for use in perineural blocks (infection or acute inflammation in the injection area, known allergy). 9. Pregnancy or breastfeeding 10. Known hypersensitivity to lidocaine, levobupivacaine, amide-linked local anaesthetics or to any of the excipients contained in the specialities used in the study. 11. Patients with recurrent porphyria or severe hypotension contraindicating treatment with lidocaine and/or levobupivacaine 12. Current treatment with antiarrhythmic drugs causing torsades de pointes (amiodarone, disopyramide, quinidinics, sotalol...) or with antiarrhythmic drugs with local anaesthetic activity (mexiletine or class III antiarrhythmic drugs) and cannot be discontinued. 13. Too little pain at the time of the blocks (\< 4 out of 10) 14. Need to modify analgesic pharmacological treatment at the beginning or during the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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CHU Ambroise Paré
RECRUITINGBoulogne-Billancourt, 92100, France
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Hôpital Raymond Poincaré
RECRUITINGGarches, 92380, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Robot could let stroke patients rehab their hands at home without a therapist
- Moving patterns may help stroke survivors read faster
- Vibrating wearables put stroke walking to the test
- Robot plus electrical stimulation aims to rebuild arm movement after stroke
- Can a checklist and heart monitor stop repeat strokes?
- Heart hole or stroke trigger? global registry tracks who gets closure and what happens next