Institut National De La Santé Et De La Recherche Médicale, France

This study aims to find markers in menstrual blood that can diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at samples before and after surgery in some patients…

This study tests whether combining brain stimulation (rTMS) with a brain-computer interface can help people who had a stroke more than 6 months ago regain arm movement. The brain-computer interface translates thoughts of moving into electrical muscle stimulation. The trial will e…

This study tests whether numbing a nerve in the arm or leg can reduce the severe, hard-to-treat pain some people feel after a stroke. Researchers will give 36 adults either one of two numbing medicines or a saltwater injection, then measure pain changes. The goal is to see if blo…

This study looks at brain activity in a person with a rare genetic condition called PRRT2 mutation, which causes sudden, uncontrollable movements. The participant will undergo brain scans (fMRI and EEG) during and after these episodes, and also when they voluntarily mimic the mov…

This study will follow 40 men with Fabry disease for three years using a small implantable heart monitor. The goal is to detect abnormal heart rhythms and conduction problems that might otherwise go unnoticed. Researchers will also look at how these electrical issues relate to he…

This Phase 1 study is testing whether high doses of the antiviral drug favipiravir are safe and tolerable in healthy volunteers. About 39 participants will receive either favipiravir or a placebo for 14 days, with doses increasing in three groups. Researchers will also measure dr…

This study aims to understand how our sense of touch works by recording nerve signals in healthy volunteers as they touch different surfaces, temperatures, and textures. Researchers will also test how emotions and age affect touch. The goal is to use this knowledge to create pros…

This study follows 500 extremely preterm infants who received paracetamol or placebo in the TREOCAPA trial. Researchers will use a parent questionnaire to assess cognitive development at age 2. The goal is to see if early paracetamol use improves thinking and learning skills in t…

This European study will follow 400 people with cystinosis, a rare genetic disease that causes cystine buildup in cells, leading to kidney failure and other organ problems. Researchers will collect clinical data and quality-of-life reports from patients across several countries. …

This study uses virtual reality games and EEG brain scans to understand how people with schizophrenia or bipolar disorder experience the passage of time. Researchers will compare 120 participants (patients and healthy volunteers) as they perform tasks in virtual environments. The…

The CONEXUS study is testing a new type of brain imaging called functional ultrasound (fUS) in newborns at high risk for neurodevelopmental disorders. Researchers want to see if this painless, non-invasive technique can measure brain connectivity and detect early signs of problem…

This study will follow 500 adults and children with Still disease, a rare inflammatory condition causing fever, joint pain, and rash. Researchers aim to compare how the disease affects different age groups, identify early markers, and improve care. No new treatments are being tes…

This study will use MRI and ultrasound to create detailed reference images of the heart, liver, and blood vessels in 2,400 healthy adults across France. By linking these images with health data, researchers hope to better understand normal aging versus disease, especially for con…

This study looks at how a concussion before age 6 might change a child's brain and behavior. Researchers will use MRI scans to compare 30 children with a concussion to 30 children with a broken arm or leg. The goal is to better understand the short- and long-term effects of mild …

This study looks at how healthy aging changes the way our brains process time. Researchers will use brain scans (EEG, fMRI, and PET) to measure brain activity and dopamine levels in 130 adults aged 20-35 and 60-85 while they judge short durations. The goal is to understand why ti…

This study is collecting medical information from 1000 people in France with mucopolysaccharidosis (MPS) diseases. The goal is to learn more about how these rare conditions progress and how they are managed with or without treatment. Participants do not receive any new therapy; i…

This study aims to understand the full burden of 9 rare skin diseases—including physical, emotional, social, and financial challenges—on patients and their families. Researchers will use special questionnaires to track how these conditions affect daily life and care needs. About …

This study looks at how trauma from the 2015 Paris attacks may affect not just those directly exposed, but also their children. Researchers will compare families who were at the attacks with those who were not, using interviews, questionnaires, and brain scans. The goal is to und…

This study looks at immune cells called macrophages in people with ALS, a disease that affects movement. Researchers will compare these cells between ALS patients, healthy people, and those with other motor problems. The goal is to find new targets for future treatments and bette…

This study aims to build a database of genetic information from 1,000 people with intellectual disabilities or autism spectrum disorders of known genetic cause. Families will answer online questionnaires to share clinical details, helping researchers understand how different gene…

This study uses advanced PET scans to examine how traumatic coma affects the brain's dopamine system. Researchers will compare three groups: people in a coma after severe head injury, those who have recovered from such an injury, and healthy volunteers. By imaging dopamine pathwa…

This study is looking for new genes and biological markers that cause systemic autoinflammatory diseases (SAIDs), a group of rare conditions that cause repeated fevers and inflammation. Researchers will analyze the DNA and blood of 300 patients to find disease-causing mutations a…

This study follows 500 adults who either have a genetic defect or autoantibodies that weaken their type I interferon immune response. Researchers will collect blood samples and health data over 1 to 4 years to track infections, autoimmune diseases, and cancers. The goal is to bet…

This study collects blood and tissue samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, such as cell clusters and mouse tumors, to study these diseases and test new treatments. The goal is to improve unders…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune or inflammatory diseases, as well as healthy controls. Researchers will analyze these samples to find molecular patterns that could lead to a tool for better diagnosis and treatment decisio…

This study looks at why some women with anorexia nervosa recover after hospital treatment while others relapse. Researchers will use brain imaging, blood tests, and thinking tasks to find clues. About 125 women with anorexia and 100 healthy women will take part, with follow-ups a…

This study aims to better understand how epileptic seizures start by recording brain activity in 50 patients with drug-resistant focal epilepsy. Participants already have electrodes implanted as part of their clinical care. The research focuses on identifying changes in single ne…

This study follows 1,000 adults who have been part of a long-term asthma research project for 30 years. Researchers want to see if people with asthma have a higher risk of heart disease compared to those without asthma. They will measure heart risk scores and other health markers…

This study looks at how a mother's emotional well-being during pregnancy might influence her baby's brain development when the baby has a serious heart condition. Researchers will follow 174 mothers and their babies from the third trimester until the child is one year old. No tre…

This study aims to find the genetic causes of Developmental Language Disorder (DLD), a condition where children have trouble learning language without other known medical issues. Researchers will analyze DNA from 50 children and their families using advanced genetic tools. The go…

This study follows 2000 children and adults with rare genetic conditions called imprinting disorders, such as Silver-Russell and Prader-Willi syndromes. Researchers will track health over time to find common metabolic problems like obesity, diabetes, and heart disease. The goal i…

This study looks at whether exposure to chlordecone, a pesticide banned in 1993 but still present in the environment, is linked to prostate cancer in men from Martinique. Researchers will compare 3600 men with and without prostate cancer, measuring chlordecone levels in blood and…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This study is gathering information from 300 people with Primary Ciliary Dyskinesia (PCD), a rare inherited lung disease. Researchers will look at medical records and genetic data to find patterns that predict how severe the disease becomes. The goal is to improve care and qualit…

This study is testing and improving how MRI machines take pictures of the brain. Researchers want to make the images clearer and reduce blurring or distortions. About 230 healthy adults aged 18 and older will participate. The goal is to create better scanning methods for future r…

This study looks at how the immune system damages the gut in diseases like celiac disease and inflammatory bowel disease. Researchers will analyze immune cells and DNA from 200 adults to understand what goes wrong. The goal is to learn more about these conditions, not to test a n…

This study aims to find out why some people with fatty liver disease or alcohol-related liver disease develop liver cancer. Researchers will look at metabolic factors, immune system responses, and imaging data from 710 participants. The goal is to identify early warning signs, es…

This study looks at how a gentle electrical current applied to the brain (called tACS) can change movement-related brain activity in people who had a stroke more than 6 months ago. About 45 participants, including healthy volunteers, will undergo different stimulation frequencies…

This study follows 700 people with Alport syndrome, a rare inherited disease that can cause kidney failure, hearing loss, and eye problems. Researchers will collect health data over time to understand how the disease progresses and find early warning signs. The goal is to prepare…

This study aims to find genetic factors that explain why people with the same LMNA gene mutation can have very different muscle and heart symptoms. Researchers will collect small muscle or skin samples from 40 patients to analyze DNA, RNA, and proteins. The goal is to identify 'm…

This study aims to understand exactly how the drug interferon attacks cancer stem cells in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will analyze blood samples from 80 adults to see why some patients respond well while others do not. T…

This study aims to find early markers for ALS, a disease that affects nerve cells and muscles. Researchers will compare blood, tears, urine, and spinal fluid from 60 people—including those with ALS gene mutations but no symptoms, early-stage ALS patients, and healthy controls. Th…

This study looks at 50 people with OCD or Tourette syndrome to find clear differences between compulsions and tics. Participants wear a smartwatch and a portable brain-wave recorder at home and in the lab. The goal is to help doctors choose the right treatment by using objective …

This study is for children and adults with interstitial lung disease, a group of conditions that scar the lungs and make breathing hard. Researchers will follow 3000 patients and their relatives for up to 10 years, collecting medical data and genetic information. The goal is to l…

This study follows 7,500 adults for 12 to 16 years to see how their arteries change with age and what that means for heart disease risk. Researchers use advanced ultrasound to measure artery stiffness and thickness. No treatment is given—the goal is simply to learn more about the…

This study is looking at the genes of 3800 people with autism to find specific changes that might be linked to the condition. The goal is to better understand which genes are involved and how they work, which could help in developing new treatments in the future. Participants pro…

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in th…

This study compares whole genome sequencing with standard genetic tests to see if it can better identify genetic causes of atypical diabetes. Researchers will follow 1,020 adults with unusual diabetes for 5 years. The goal is to improve diagnosis and tailor treatment based on gen…

This study looks at how imagining movements (mental training) helps healthy adults learn physical skills like finger sequences or arm movements. Researchers use brain stimulation and robotic tools to measure changes in brain activity and performance. The goal is to understand the…

This study follows 800 children born with eye malformations like microphthalmia, anophthalmia, aniridia, or anterior segment defects. Researchers will track their vision, brain development, and overall health for up to 10 years to better predict outcomes. No new treatments are be…

This study explores how certain immune cells (MAIT cells) and gut bacteria work together in children who either have type 1 diabetes, are at high genetic risk, or are healthy. Researchers will collect blood and gut samples from 180 children to understand these interactions. The g…