Institut National De La Santé Et De La Recherche Médicale, France

This study aims to find markers in menstrual blood that can diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at samples before and after surgery in some patients…

This study explores whether combining brain-computer interfaces (BCIs) with magnetic brain stimulation can help people with chronic stroke regain arm movement. About 50 participants who had a stroke at least 6 months ago and have limited arm function will test personalized BCI sy…

This study tests whether numbing a nerve in the arm or leg can reduce the severe, hard-to-treat pain some people feel after a stroke. Researchers will give 36 adults either one of two numbing medicines or a saltwater injection, then measure pain changes. The goal is to see if blo…

This study looks at how a mother's emotional well-being during pregnancy might influence her baby's brain development when the baby has a serious heart condition. Researchers will follow 174 mothers and their babies from the third trimester until the child is one year old. No tre…

This study looks for new genes and biological clues in people with rare autoinflammatory diseases (SAIDs), which cause repeated fevers and inflammation. Researchers will use advanced genetic testing and blood analysis to find disease-causing mutations and understand how these dis…

This study looks at whether exposure to chlordecone, a pesticide banned in 1993 but still present in the environment, is linked to prostate cancer in men from Martinique. Researchers will compare 3600 men with and without prostate cancer, measuring chlordecone levels in blood and…

This study collects tissue and blood samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, like cell clusters and mouse tumors, to test new treatments. The goal is to better understand these diseases and devel…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This study is gathering information from 300 people with Primary Ciliary Dyskinesia (PCD), a rare inherited lung disease. Researchers will look at medical records and genetic data to find patterns that predict how severe the disease becomes. The goal is to improve care and qualit…

This study collects health data from 1,000 people in France with mucopolysaccharidosis (MPS) diseases. Researchers will track symptoms, growth, organ function, and lab results over time to better understand how these rare genetic conditions progress and respond to treatments. The…

This study is testing and improving how MRI machines take pictures of the brain. Researchers want to make the images clearer and reduce blurring or distortions. About 230 healthy adults aged 18 and older will participate. The goal is to create better scanning methods for future r…

This study looks at how healthy aging changes the way our brains process time. Researchers will use brain scans (EEG, fMRI, and PET) to measure brain activity and dopamine levels in 130 young and older adults while they judge durations. The goal is to understand why time percepti…

This study tests a new, painless ultrasound technique called functional ultrasound imaging (fUS) to see if it can measure brain activity in newborns at high risk for developmental disorders. Researchers will scan 76 babies, including those born very early or with other risk facto…

This study looks at how the immune system damages the gut in diseases like celiac disease and inflammatory bowel disease. Researchers will analyze immune cells and DNA from 200 adults to understand what goes wrong. The goal is to learn more about these conditions, not to test a n…

This study is testing high doses of the antiviral drug favipiravir in healthy volunteers to see if it is safe and how the body handles it. About 39 healthy adults will take either favipiravir or a placebo for 14 days. The goal is to understand side effects and drug levels in bloo…

This study aims to find out why some people with fatty liver disease or alcohol-related liver disease develop liver cancer. Researchers will look at metabolic factors, immune system responses, and imaging data from 710 participants. The goal is to identify early warning signs, es…

This study will follow 500 adults and children with Still disease, a rare inflammatory condition causing fevers, joint pain, and rash. Researchers want to learn why the disease affects different age groups and why symptoms vary. The goal is to improve diagnosis, find better treat…

This study follows 40 men with Fabry disease for three years using a small heart monitor placed under the skin. The goal is to see how often heart rhythm problems occur and how they relate to changes seen on heart scans and blood tests. Participants must not have had certain hear…

This study looks at how a gentle electrical current applied to the brain (called tACS) can change movement-related brain activity in people who had a stroke more than 6 months ago. About 45 participants, including healthy volunteers, will undergo different stimulation frequencies…

This study aims to collect detailed medical images (MRI and ultrasound) of the heart, liver, and blood vessels from 2,400 healthy volunteers across France. By linking these images with health data, researchers hope to establish normal ranges for different ages and sexes. This wil…

This study follows 700 people with Alport syndrome, a rare inherited disease that can cause kidney failure, hearing loss, and eye problems. Researchers will collect health data over time to understand how the disease progresses and find early warning signs. The goal is to prepare…

This study aims to find genetic factors that explain why people with the same LMNA gene mutation can have very different muscle and heart symptoms. Researchers will collect small muscle or skin samples from 40 patients to analyze DNA, RNA, and proteins. The goal is to identify 'm…

This study follows up on 500 extremely preterm infants who were part of a larger trial testing paracetamol to close a common heart vessel. Researchers want to see if those who received paracetamol have better thinking and learning skills at age 2. Parents will answer an online qu…

This study explores how people with schizophrenia or bipolar disorder experience time differently than healthy individuals. Using virtual reality games that involve waiting and reacting to targets, researchers measure brain signals (EEG) and behavior. The goal is to better unders…

This study will follow 2000 children and adults with rare genetic conditions called imprinting disorders, such as Silver-Russell and Prader-Willi syndromes. Researchers want to find common metabolic patterns and health risks like obesity or diabetes. No new treatments are tested;…

This study aims to understand exactly how the drug interferon attacks cancer stem cells in people with myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will analyze blood samples from 80 adults to see why some patients respond well while others do not. T…

This study aims to find early markers for ALS, a disease that affects nerve cells and muscles. Researchers will compare blood, tears, urine, and spinal fluid from 60 people—including those with ALS gene mutations but no symptoms, early-stage ALS patients, and healthy controls. Th…

This study aims to learn more about the genetic causes of intellectual disability and autism spectrum disorder. Researchers will collect information from families of people with known genetic mutations through online questionnaires. The goal is to better understand how these cond…

This study looks at 50 people with OCD or Tourette syndrome to find clear differences between compulsions and tics. Participants wear a smartwatch and a portable brain-wave recorder at home and in the lab. The goal is to help doctors choose the right treatment by using objective …

This study is for children and adults with interstitial lung disease, a group of conditions that scar the lungs and make breathing hard. Researchers will follow 3000 patients and their relatives for up to 10 years, collecting medical data and genetic information. The goal is to l…

This study follows 1,000 adults who took part in earlier EGEA surveys to explore whether asthma increases the risk of heart disease. Researchers will compare heart health markers, like the Framingham score and blood tests, between people with and without asthma. The goal is to un…

This study follows 7,500 adults for 12 to 16 years to see how their arteries change with age and what that means for heart disease risk. Researchers use advanced ultrasound to measure artery stiffness and thickness. No treatment is given—the goal is simply to learn more about the…

This study looks at immune cells (macrophages) from 180 people with ALS, people with other motor problems, and healthy volunteers. Researchers want to find differences in these cells that could lead to new treatments or ways to diagnose ALS earlier. No treatment is given; this is…

This study gathers health information from 400 people with cystinosis, a rare disease that causes cystine buildup and organ damage. Researchers aim to track patient outcomes and quality of life over time to identify where care can be improved. Participants include children and ad…

This study is looking at the genes of 3800 people with autism to find specific changes that might be linked to the condition. The goal is to better understand which genes are involved and how they work, which could help in developing new treatments in the future. Participants pro…

This study aims to understand how 9 rare skin diseases affect people's lives, including their emotions, social life, finances, and physical health. Researchers will ask 900 patients and their families to fill out questionnaires about their daily challenges and the resources they …

This study aims to understand how our sense of touch works in healthy people, so that this knowledge can be used to create prosthetic limbs that provide realistic sensory feedback. Researchers will use a technique called microneurography to record nerve signals while participants…

This study is collecting blood samples from 1,160 people with and without type 1 diabetes to analyze the immune cells that mistakenly attack the pancreas. The goal is to better understand how these cells work, which could lead to improved treatments or prevention strategies in th…

This study compares whole genome sequencing with standard genetic tests to see if it can better identify genetic causes of atypical diabetes. Researchers will follow 1,020 adults with unusual diabetes for 5 years. The goal is to improve diagnosis and tailor treatment based on gen…

This study looks at how imagining movements (mental training) helps healthy adults learn physical skills like finger sequences or arm movements. Researchers use brain stimulation and robotic tools to measure changes in brain activity and performance. The goal is to understand the…

This study looks at how a concussion before age 6 might change a child's brain structure and behavior. Researchers will use MRI scans to compare 30 children with a mild concussion to 30 children with a broken arm or leg. The goal is to better understand the short- and long-term e…

This study looks at how trauma from the 2015 Paris attacks might be passed from parents to children. Researchers will compare families who were directly exposed to the attacks with those who were not. They will use interviews, brain scans, sleep tracking, and hormone tests to und…

This study follows 800 children born with eye malformations like microphthalmia, anophthalmia, aniridia, or anterior segment defects. Researchers will track their vision, brain development, and overall health for up to 10 years to better predict outcomes. No new treatments are be…

This study aims to uncover the genetic causes of Developmental Language Disorder (DLD), a condition where children have trouble learning language for no known medical reason. Researchers will analyze DNA from 50 children and their families using advanced genome sequencing. The go…

This study looks at why some women with anorexia nervosa get better after hospital treatment but then relapse. Researchers will use brain scans, thinking tests, and blood samples to find clues. 125 women with anorexia and 100 healthy women will take part. The goal is to understan…

This study explores how certain immune cells (MAIT cells) and gut bacteria work together in children who either have type 1 diabetes, are at high genetic risk, or are healthy. Researchers will collect blood and gut samples from 180 children to understand these interactions. The g…

This study follows 500 adults who have either a genetic flaw or self-made antibodies that weaken their type I interferon immune system, making them more vulnerable to viruses like COVID-19. Over 1 to 4 years, researchers will track infections, autoimmune diseases, and cancers thr…

This study looks at brain activity during sudden movement episodes in people with a rare genetic condition called PRRT2-related paroxysmal dyskinesia. Only one participant who can control these episodes will be enrolled. Using MRI and EEG, researchers hope to understand which bra…

This study explores how traumatic brain injury affects dopamine pathways in the brain during coma. Researchers will use advanced PET and MRI scans in 55 participants (coma patients, recovered patients, and healthy volunteers) to measure dopamine activity. The goal is to better un…

This study aims to create a tool that helps doctors diagnose and choose treatments for autoimmune diseases more accurately. Researchers will analyze blood and other samples from 500 children with autoimmune conditions and healthy children to find molecular patterns. The goal is t…

This study aims to understand how epileptic seizures start by recording brain activity with tiny electrodes implanted in the brains of 50 people with epilepsy who are already scheduled for surgery. Researchers will also look at normal brain functions like sleep and thinking. The …