Institut National De La Santé Et De La Recherche Médicale, France

This study follows 2000 children and adults with rare genetic conditions called imprinting disorders (such as Silver-Russell and Prader-Willi syndromes). Researchers will track their health over time to find common metabolic problems like obesity, diabetes, and heart disease. The…

This study gathers health information from 400 people with cystinosis, a rare disease that causes cystine buildup and organ damage. Researchers will track kidney function, growth, and quality of life over time. The goal is to identify gaps in care and improve treatment standards …

This study explores how certain immune cells (MAIT cells) and gut bacteria work together in children who either have a high genetic risk for type 1 diabetes or were recently diagnosed. Researchers will compare these children to healthy controls to understand changes that may lead…

This study looks at what happens in the brain during brief, uncontrollable movement episodes in people with a rare genetic condition (PRRT2 mutation). Only one person who can start and stop these episodes on command will take part. Using MRI and EEG, researchers hope to understan…

This study looks at how trauma can be passed down within families—both through biology and behavior. Researchers will compare families who were directly exposed to the November 2015 Paris attacks with those who were not. About 960 parents and children will complete interviews, qu…

This study looks at how imagining movements (mental training) helps healthy adults learn physical tasks like finger sequences. Researchers use brain stimulation and robotic tools to measure changes in brain activity and movement accuracy. The goal is to understand the brain's rol…

This study follows 40 men with Fabry disease for three years using a small heart monitor implanted under the skin. The goal is to see how often heart rhythm problems occur and how they relate to changes seen on heart scans and blood tests. The study does not test a new treatment …

This study collects tissue and blood samples from 800 people with chronic liver disease or liver cancer. Researchers will use these samples to create lab models, like cell clusters and mouse tumors, to test new treatments. The goal is to better understand these diseases and devel…

This study looks at how a concussion before age 6 might change a child's brain and behavior. Researchers will compare brain scans of 30 children with a concussion to 30 children with a broken arm or leg. The goal is to better understand the short- and long-term effects of mild he…

This study tests a new, painless ultrasound technique called functional ultrasound imaging (fUS) to see if it can measure brain activity in newborns at high risk for developmental disorders. Researchers will scan 76 babies, including premature infants and those with birth complic…

This study aims to better understand Primary Ciliary Dyskinesia (PCD), a rare genetic lung disease. Researchers will collect data from 300 patients to identify factors that predict disease severity, assess quality of life, and explore how specific genes relate to symptoms. The go…

This study follows 500 adults who have either a genetic defect or self-attacking antibodies that weaken their type I interferon immune system. Researchers will track infections, autoimmune diseases, and cancers over 1 to 4 years through yearly checkups and health database records…

This study looks at how a mother's mental health during pregnancy affects the brain development of babies born with a serious heart condition. Researchers will follow 87 mothers and their babies from the third trimester until the child is one year old. No treatments are given—the…

This study follows 1,000 adults who took part in earlier surveys to understand if asthma increases the risk of heart disease. Researchers will compare heart health markers in people with and without asthma. The goal is to find out whether asthma itself or shared risk factors like…

This study will collect health information from 1,000 people in France with mucopolysaccharidosis (MPS), a group of rare genetic disorders. Researchers aim to better understand how the disease progresses and how it is currently managed with or without specific treatments. No new …

This study will follow 500 adults and children with Still disease, a rare inflammatory condition causing fevers, joint pain, and rash. Researchers want to learn why the disease affects different age groups and why symptoms vary. By collecting health data and blood samples over ti…

This study follows up on 500 extremely preterm infants who received paracetamol or a placebo in a previous trial to see if early treatment helps close a heart vessel and improves thinking skills at age 2. Parents will answer online questionnaires about their child's development. …

This study aims to find clear differences between tics (as in Tourette syndrome) and compulsions (as in OCD) by measuring brain activity and movement. Fifty patients will wear EEG headsets and smartwatches in the lab and at home. The goal is to improve diagnosis and guide better …

This study aims to understand exactly how the drug interferon attacks cancer cells in people with certain blood cancers called myeloproliferative neoplasms (MPNs). Researchers will analyze blood samples from 80 adults to see why some patients respond well and others do not. The g…

This study tests whether using gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before and after a 5-week vibration treatment. The goal is to under…

This study explores whether combining brain-computer interfaces (BCIs) with repeated transcranial magnetic stimulation (rTMS) can improve arm movement in people who had a stroke at least 6 months ago. Researchers will enroll 50 participants to test if these technologies can help …

This study looks at people with LMNA gene mutations that cause muscle and heart problems. Researchers want to find out why some patients have mild symptoms while others have severe disease. They will collect muscle and skin samples and use advanced genetic techniques to identify …

This study looks at how healthy aging changes the way our brain processes time. Researchers will compare young adults (20-35 years) and older adults (60-85 years) using brain scans and timing tasks. The goal is to understand why time perception declines with age and find new ways…