Institut National De La Santé Et De La Recherche Médicale, France

This study tested a higher dose of a new nasal vaccine (BPZE1) for whooping cough in 54 healthy adults aged 18-32. The goal was to see if the higher dose is safe and helps the vaccine take hold in the nose to trigger protection. Researchers monitored side effects and checked if t…

This study looked at whether combining school education, doctor training, and offering the vaccine at school can increase HPV vaccination among French adolescents aged 11 to 14. Over 30,000 teens from 90 towns took part. The goal was to see if these efforts make more teens get th…

This study tested a flu vaccine (H1N1) in 122 kidney transplant patients to see if it is safe and helps their immune system fight the flu. Participants were adults who had a kidney transplant at least 6 months ago and were on stable immunosuppressive drugs. The vaccine was given …

This early-stage study tested a new whooping cough vaccine given as a nasal spray. 48 healthy adult men received either the vaccine or a placebo to check safety and immune response. The goal is to develop a single-dose nasal vaccine that can protect very young infants, who are mo…

This early-stage trial tested a new vaccine called PRIMVAC, designed to prevent malaria in pregnant women. Researchers gave 68 healthy adults in France and Burkina Faso three different doses of the vaccine to check its safety. The study is a first step toward protecting mothers a…

This study tested an inactivated H1N1 flu vaccine in 110 pregnant women to see if it is safe and helps their bodies build protection against the flu. Participants received two doses of the vaccine and were monitored for side effects. The goal was to learn whether the vaccine work…

This early-stage study tested a DNA vaccine in 10 adults with chronic hepatitis B who had not responded to standard treatments. The goal was to see if the vaccine is safe and can help the immune system fight the virus. Researchers monitored side effects and immune responses after…

This early-stage trial tested a new malaria vaccine in 66 healthy adults from Europe and Africa. The goal was to see if the vaccine is safe and how the immune system responds. Participants received three doses over six months, and researchers monitored for side effects and immune…

This study tested whether adding the drug AZD7442 to standard care helps hospitalized adults with COVID-19 recover faster. About 1,500 participants received either the drug or a placebo. The main goal was to see how their symptoms changed over time, from being able to do normal a…

This study tested the drug rapamycin in 44 adults with Inclusion Body Myositis, a rare muscle disease that causes progressive weakness. The goal was to see if rapamycin could slow the loss of muscle strength. Participants received either rapamycin or a placebo, and their muscle s…

This study tested whether a special oil called triheptanoin can slow brain damage and improve symptoms in people with early Huntington's disease. About 100 adults took either the oil or a placebo for 6 months, then everyone received the oil for another 6 months. Researchers measu…

This study tested whether giving acetaminophen (a common pain reliever) to extremely preterm babies (born before 28 weeks) could help close a blood vessel in the heart that normally closes after birth. The trial involved 804 infants across Europe and aimed to improve survival wit…

This study tested a special oil called triheptanoin in 20 people with GLUT1 deficiency, a rare condition where the brain can't use sugar for energy. The goal was to see if the oil could reduce episodes of abnormal movements and seizures. Participants took the oil by mouth, and do…

This study tested a new way to help broken bones that are taking too long to heal. Doctors took a small sample of the patient's own bone marrow, grew the stem cells in a lab, and then placed them with a special bone-like material at the fracture site. The goal was to see if this …

This early study tested whether a 3-week course of sitagliptin, a diabetes drug, is safe for people with liver cancer (HCC) who are having part of their liver removed. Only 14 patients took part. The goal was to see if the drug could help the immune system attack the tumor by pro…

This study tested three drugs (Xenbilox, Tahor, and Resveratrol) in 12 adults with a rare inherited form of spastic paraplegia called SPG5. The goal was to lower levels of harmful oxysterols, which are toxic byproducts of cholesterol that damage nerve cells. Each participant took…

This study tested whether giving extra support—like cooking classes, motivational talks, and financial help for physical activity—to overweight teens from less advantaged backgrounds helps them manage their weight as well as standard care helps teens from more advantaged backgrou…

This study tested whether a high dose of the drug favipiravir could lower the death rate in people with Ebola. The trial included 126 patients in Guinea. Researchers measured how many people died after taking the drug, and also tracked side effects and virus levels in the blood.

This early-phase trial tested whether injecting a person's own bone marrow stem cells into the penis could help restore natural erections after prostate cancer surgery. The study included 18 men who had normal erections before surgery but developed erectile dysfunction due to ner…

This study tested a drug called anakinra in 24 children and young adults (ages 2-20) with severe systemic-onset juvenile idiopathic arthritis (SO-JIA) that did not respond well to steroids. For the first month, half received anakinra and half received a placebo, then all received…

This study tested a vaccine called Bilhvax (Sh28GST) given alongside a standard treatment (praziquantel) to see if it could delay the return of schistosomiasis, a parasitic infection that affects the bladder, in children aged 6 to 9 in Senegal. The trial involved 250 children who…

This study tested artesunate, a malaria drug, in 20 people with Friedreich ataxia to see if it can safely help control the disease by improving how the body handles iron. Researchers looked for the best dose that works without causing serious side effects. The goal is to manage t…

This study tested a gene therapy for children with a rare, severe brain disease called metachromatic leukodystrophy (MLD). The treatment involved injecting a harmless virus carrying a working copy of the missing gene directly into the brain. Five children aged 6 months to 5 years…

This study looked at 100 newborns with suspected or confirmed yeast infections (candidiasis). Researchers compared two antifungal drugs, fluconazole (the current standard) and micafungin, to see which is safer and more effective. The goal was to find the best treatment for these …

This study looked at whether regular follow-up visits with nurses and dietitians help people with type 2 diabetes manage their condition better. 398 adults with type 2 diabetes first received a week of education on diet and exercise. Then half were assigned to frequent check-ins …

This study looked at whether measuring a protein called EG-VEGF in the blood of pregnant women between 14 and 18 weeks could help predict pre-eclampsia or intrauterine growth restriction (poor fetal growth). Researchers enrolled 142 women and measured EG-VEGF levels, comparing th…

This study tested whether a brain region called the superior colliculus, which processes visual information, could help diagnose Parkinson's disease earlier. Researchers compared brain scans of 23 newly diagnosed Parkinson's patients and healthy volunteers while they looked at vi…

This study tested whether whole genome sequencing (WGS) can find more genetic causes of intellectual disability than current standard tests. Researchers compared WGS to usual methods in 3825 children and adults with unexplained intellectual disability. The goal was to see if WGS …

This study tested whether a smartphone app called Apneal can accurately diagnose sleep apnea in adults. Nearly 500 participants wore the app during a standard overnight sleep test. The goal was to see if the app could correctly identify the severity of sleep apnea, from mild to s…

This study aimed to create a simple scoring system to help doctors diagnose tuberculosis (TB) in hospitalized children aged 2 to 59 months who also have severe acute malnutrition. Researchers in Uganda and Zambia tested various diagnostic methods in 603 children to find the most …

This study tested whether a patient navigator—someone who helps guide people through the healthcare system—could increase participation in colorectal cancer screening. Nearly 29,000 French adults aged 50-74 who had not been screened were included. The goal was to see if this appr…

This study tested whether promoting a free web and mobile tool called StopBlues could reduce suicide and psychological distress in the general population. Over 100,000 adults from 42 French communities took part. Some communities promoted the tool, while others did not, and resea…

This study looked at how well the seasonal flu vaccine works in adults who are hospitalized with severe flu-like illness. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine reduced confirmed flu cases. The goal is …

This pilot study tested whether a personalized program combining physical activity, cognitive training, and nutritional advice could prevent mobility disability in 210 older adults (60+) who were frail or pre-frail. Participants were followed for their ability to walk 400 meters.…

This study tested a simple method to help C-section babies develop a healthier gut. Researchers gave newborns a swab coated with their mother's vaginal fluids right after birth. The goal was to see if this could restore the natural gut bacteria that babies usually get during a va…

This study measured how effective the seasonal flu vaccine was at preventing flu in adults who were hospitalized with flu-like symptoms. Researchers compared the number of lab-confirmed flu cases between vaccinated and unvaccinated patients across a network of French hospitals. T…

This study looked at whether caffeine can reduce involuntary movements in people with a rare genetic condition called ADCY5-related dyskinesia. Fifteen participants who already used caffeine were surveyed by phone about changes in their symptoms. The goal was to see if at least 4…

This study tested a program called "Choizitaconso" that teaches people with alcohol use disorder how to control their drinking and reduce harm. About 110 adults took part, learning skills to manage their alcohol use and avoid negative consequences. The goal was to see if the prog…

This study tested a device called MyoRegulator® to see if it can safely reduce muscle stiffness in the lower leg after a stroke. 44 adults who had a stroke at least 6 months ago and had leg spasticity received either real or sham treatment for 5 days. The main goal was to measure…

This study tested whether combining a drug called galantamine with a specific cognitive training program could improve thinking skills in adults aged 35-70 who had a first stroke 3 months earlier. 47 participants received either the drug or a placebo, plus brain training, and wer…

This study tested whether a blend of online and in-person therapy works as well as traditional face-to-face therapy for adults with major depression. 105 French adults participated, and researchers tracked their depression symptoms over time. The goal was to see if the online app…

This study tested whether a special video game program could help people with Parkinson's disease who have trouble walking and keeping their balance. 25 participants played the games as part of their rehabilitation. The goal was to see if this fun approach could improve their mob…

This study looked at 80 pregnant women with too much amniotic fluid (polyhydramnios) causing discomfort. Researchers compared two drainage methods: manual syringe removal versus continuous suction. The goal was to see which technique causes less pain and is safer for both mother …

This study tested whether a measles vaccine could help control eczema (atopic dermatitis) in adults. Researchers gave 20 adults with moderate-to-severe eczema either the measles vaccine or a placebo and tracked their symptoms for 45 days. The goal was to see if the vaccine could …

This study tested whether an 8-week mindfulness program could reduce anxiety in older adults (60+) who worry about their memory but still score normally on memory tests. 168 participants were randomly assigned to either mindfulness training or a health education program. The goal…

This study tested whether a dietary oil called triheptanoin can improve exercise ability in adults with McArdle disease, a rare genetic disorder that makes it hard for muscles to use stored sugar for energy. Twelve participants took triheptanoin or a placebo for two weeks each, t…

This study looked at whether taking weekly dance classes for 8 months can help people with Huntington's disease and their caregivers. Researchers measured movement control, emotion, quality of life, and brain changes using tests and MRI scans. The goal was to see if dance trainin…

This study tested whether a mild electrical current applied to the back of the head (cerebellum) can reduce shaking in people with essential tremor. Sixteen adults whose usual treatments weren't working well took part. Researchers measured tremor changes using rating scales and m…

This study tested a gentle electrical stimulation applied to the spine in 18 people with primary orthostatic tremor, a condition that causes leg shaking when standing. The goal was to see if this stimulation could help them stand longer without support. The approach is non-invasi…

This study tested whether deep brain stimulation of a specific brain region could improve walking and balance problems in people with advanced Parkinson's disease. Six participants received the stimulation in a randomized, double-blind crossover design. The goal was to see if thi…

This study tested whether triheptanoin oil can reduce the number of sudden paralysis episodes in children with Alternating Hemiplegia of Childhood, a rare genetic disorder. Ten participants took the oil or a placebo in a crossover design. The main goal was to see if the oil could…

This study looked at how many people in homeless shelters in Paris had COVID-19 antibodies after the first wave. Researchers tested 179 residents and staff from three shelters to measure past infections and deaths. The goal was to understand the virus's impact on a vulnerable pop…

This study looked at immune cells from 4 healthy people shortly after they got a smallpox vaccine. Researchers wanted to see if these cells already show signs of long-term memory. The goal was to understand how the body builds lasting protection after vaccination.

This study aimed to describe breathing problems in 70 people with severe multiple sclerosis (MS). Researchers measured how well the breathing muscles work and how lung function changes with position. The goal was to better understand respiratory issues in this group, not to test …

This study followed 919 pregnant women in Paris to see how often they caught H1N1 flu during the 2009 pandemic and what happened to their pregnancies. Researchers also checked if the flu vaccine was safe. The goal was to better understand the risks of flu during pregnancy.

This study looked at how people with ALS start walking and keep their balance. Researchers compared patients with and without balance problems, plus healthy volunteers, using walking tests and brain scans. The goal was to understand the brain changes behind movement difficulties,…

This study looked at how motivational interviewing—a type of talk therapy—affects the brain's response to food in people with food addiction. 56 participants, including those with obesity and healthy controls, had their brains scanned while making food choices after saying statem…

This study looked at how the immune system responds in people with colon cancer. Researchers collected blood and tumor tissue samples from 100 patients and followed them for up to 5 years. The goal was to understand immune cell activity, not to test a new treatment.

This study looked at how 10 different drugs are broken down in the body. Ten healthy volunteers took the drugs, and researchers measured levels in the blood to create a personal metabolic profile. The goal was to learn more about drug processing, not to treat any disease.

This study aimed to find genetic markers that could predict which patients will develop vasospasm—a dangerous narrowing of brain arteries—after a bleeding brain aneurysm. Researchers collected blood samples daily from 89 patients for 12 days to analyze their DNA and RNA. The goal…

This study took small tissue samples from 16 people with or without inflammatory bowel disease during routine colonoscopies. Researchers grew these samples into mini-organs called organoids in the lab. They then tested how radiation and potential treatments affect these organoids…

This study looked at how COVID-19 spread in France and how people's living conditions affected the outbreak. Over 134,000 people aged 15 and older gave blood samples and answered questions about their health, work, and home life. The goal was to understand infection rates and the…

This study looked at 100 healthy men to see if a common gene variation (called TaqIB) changes how well their 'good' HDL cholesterol works. The goal was to compare HDL's ability to remove cholesterol from cells in people with different versions of this gene. The findings could hel…

This pilot study tested whether wearable sensors can measure apathy in real-life situations for people with frontotemporal dementia and healthy volunteers. 14 participants wore sensors that tracked movement, body position, and energy use. The goal was to see if this technology ca…

This study tested whether methylphenidate (a drug used for ADHD) changes how healthy adults make decisions, put in effort, and learn from rewards. 35 participants completed tasks while on the drug or a placebo. The goal was to understand motivation, not to treat any condition.

This pilot study tested whether a new MRI technique called GRICS can take clear pictures of the heart while patients breathe normally. Thirty adults with heart disease (ischemic or dilated cardiomyopathy) had both standard breath-hold and free-breathing scans. The goal was to see…

This study used a technique called transcranial magnetic stimulation (TMS) to temporarily quiet specific brain areas in 17 healthy adults. The goal was to see how these areas affect the reflex that keeps your eyes steady when you move your head. The research helps us understand w…

This study looked at Netherton syndrome, a rare genetic skin condition, to better understand how it affects the body and immune system. Researchers studied 18 people with the disease, measuring immune markers in the blood and tracking skin changes. The goal was to find new target…

This study looked at whether people who have been cured of Cushing's disease for at least a year still have memory problems. Researchers used a special virtual reality test to check memory, along with standard tests. The goal was to better understand these lasting effects and imp…

This study used eye-tracking and pupil measurements to understand how children with autism explore social cues like faces and body movements compared to objects. Researchers studied 150 children, both with and without autism, to identify differences in visual attention. The goal …

This study used brain scans to see how age influences the buildup of amyloid plaques in people with Alzheimer's disease and two related conditions (posterior cortical atrophy and logopenic progressive aphasia). Researchers compared early-onset and late-onset Alzheimer's patients,…

This study compared the sense of smell in 240 people with and without bipolar disorder. Participants took tests measuring their ability to detect, tell apart, and identify odors. The goal was to see if smell performance relates to brain imaging data, helping researchers better un…

This study tested whether healthy volunteers could collect their own blood drops using a simple finger-prick method during brief periods of weightlessness on a parabolic flight. The goal was to see if this technique works in space-like conditions for measuring caffeine levels. Th…

This study tested a new ultrasound technique to detect blood flow inside solid bone, which current methods cannot do. Nineteen healthy adults had their forearm and shin scanned while blood flow was changed using a blood pressure cuff or by changing position. The goal was to see i…

This study used special MRI techniques to see how brain cells change after a stroke. Researchers scanned 24 stroke patients and 24 healthy volunteers to measure water and chemical movement in brain tissue. The goal was to learn more about what happens inside brain cells during a …

This study looked at how people with autism spectrum disorder (ASD) pay attention to emotions and changes compared to healthy individuals. Researchers used brain scans (EEG and MRI) to measure brain activity in children and adults. The goal was to better understand these attentio…

This study used brain scans (fMRI) to understand how shared cultural knowledge, like memories of historical events, influences the way individuals remember personal experiences. Twenty-seven healthy adults who had visited a World War II memorial were asked to recall pictures whil…

This early study tested whether a painless, non-invasive brain stimulation technique called tDCS could change the brain's control over the diaphragm, the main breathing muscle. Twelve healthy men received three types of stimulation (positive, negative, and fake) while researchers…

This study looked at whether certain proteins, called beta-arrestins, can help predict how well people with major depression will respond to the antidepressant venlafaxine. Researchers measured these proteins in 67 patients before and during treatment, and compared them to health…

This study looked at how certain natural substances in urine change throughout the day in 32 people with advanced colorectal cancer and in healthy volunteers. The goal was to see if these daily patterns could one day help doctors monitor cancer therapy without invasive tests. Par…

This early-stage trial tested a single dose of an inhaled drug called FLAMOD in 46 healthy adults to see if it is safe and can activate the immune system in the lungs. The goal is to find a dose that could later be used to help prevent or fight pneumonia. No treatment benefit was…

This study looked at 99 adults with high heart disease risk to understand how a protein called CETP relates to plaque buildup in arteries. Researchers measured CETP activity in the blood and used imaging to check artery thickness and calcium. The goal was to see if CETP could ser…

This study looked at how Parkinson's disease changes the way people perceive time. Researchers measured eye movements in 40 participants (Parkinson's patients and healthy volunteers) to understand the role of dopamine in timing. Patients were tested both on and off their medicati…

This study looked at how well seasonal and H1N1 pandemic flu vaccines triggered immune responses in 147 healthy healthcare workers. Researchers wanted to see if age and past flu shots affected the body's antibody and cell-based defenses. The goal was to better understand vaccine …

This study looked at 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers collected fluid from the lungs to study the virus and the body's immune response. The goal was to learn more about what causes severe illness, not to test a new treatment.

This study looked at how the cerebellum (a part of the brain) is involved in movement, thinking, and emotions in people with myoclonus dystonia, a rare movement disorder. 47 participants (patients and healthy volunteers) had MRI scans and did small tasks. The goal was to understa…

This study followed more than 3,000 adults with moderate to advanced chronic kidney disease (CKD) for up to 5 years. Researchers collected health data and blood/urine samples to identify factors that lead to kidney failure, heart problems, and other complications. The goal was to…

This study looked at whether a special video game could help improve walking and balance in 10 people with Parkinson's disease who had already had brain surgery. The goal was to see if the game was easy and enjoyable to use. Researchers measured how well participants could walk a…

This study looked at how severe facial palsy changes the brain's ability to recognize emotions and control facial movements. Sixteen patients had their brain activity measured with a non-invasive MEG scanner before and after reconstructive surgery. The goal was to understand brai…

This study looked at 94 adults to see if following French nutrition guidelines affects blood vessel health. Participants were split into two groups based on their diet quality, and researchers measured artery stiffness and blood flow before and after a standard breakfast. The goa…

This study looked at how two brain regions—the cerebellum and the supplementary motor area—help us keep our balance when we start walking. Twenty healthy adults had their balance measured before and after temporarily 'turning off' each brain area with magnetic pulses. The goal wa…

This study looked at the DNA of over 1,600 people with autism to find genetic changes that affect how brain cells communicate. The goal was to identify which genes are linked to autism and understand the biological pathways involved. This research does not test a treatment but ai…

This study looked at how the prefrontal cortex helps us think in analogies and categories. Researchers tested healthy volunteers and patients with frontotemporal dementia or progressive supranuclear palsy using tasks that measure reaction time and accuracy. They also used brain s…

This study looked at how healthy young adults (ages 18-35) can intentionally forget negative memories. Using brain wave recordings (EEG) and tasks involving images, researchers aimed to understand the brain's natural ability to suppress unwanted thoughts. The goal is to learn mor…

This study looked at how the brain chemical dopamine works in people with idiopathic generalized epilepsy. Researchers gave 31 participants (patients and healthy volunteers) a low dose of apomorphine or a placebo and counted yawns and blinks as simple behavioral markers. They als…

This study looked at the genetic makeup of liver cancer (hepatocellular carcinoma) in 808 patients. The goal was to identify key genetic changes and patterns that could help doctors better understand and diagnose the disease. No new treatments were tested; instead, researchers co…

This study tested a new, non-invasive laser technique (Laser Doppler Vibrometry) to measure artery stiffness in 100 people with high blood pressure. The goal was to see if this laser method works as well as the current standard methods (applanation tonometry and echotracking). Th…

This study looked at how shared cultural memories (like those about World War II) affect the way individuals remember things. Twenty-six healthy adults had their brains scanned with fMRI while looking at pictures and recalling details. The goal was to understand how collective kn…

This study looked at over 1,000 mothers and daughters to understand how bone structure and strength are passed down through families. Researchers compared bone scans and fracture history between mothers who had broken a bone easily and those who hadn't. The goal was to learn more…

This study looked at whether a non-invasive brain stimulation technique called paired associative stimulation (PAS) can help improve hand movement in people who had a stroke. It included 60 stroke patients and 24 healthy volunteers. The goal was to see how the brain reorganizes i…

This study looked at the bacteria living in the small intestine and colon of 90 adults—some lean, some with obesity, and some with both obesity and type 2 diabetes. Researchers collected samples during routine endoscopies or colonoscopies to compare the gut microbes of these grou…

This study examines whether low-dose radiation to the brain during childhood (for a non-cancerous skin growth) can cause thinking or memory problems later in life. Researchers will compare adults who received different amounts of radiation to the brain. The goal is to understand …

This study tested whether adding a rapid tuberculosis (TB) test to standard care can reduce deaths in young children hospitalized with severe pneumonia. Over 2,500 children aged 2 to 59 months in six high-TB-burden countries took part. The test uses stool and nose samples to find…

This study looked at how brain energy levels change in people with early Huntington disease. Ten adults had their brain metabolism measured using a special MRI scan while they watched flashing lights. The goal was to understand how mitochondria (the energy factories in cells) wor…

This study looked at how two types of cognitive behavioral therapy (CBT) affect brain activity in people with obsessive-compulsive disorder (OCD). 35 adults with OCD completed 15 therapy sessions and had brain scans before, during, after, and 6 months later. The goal was to see i…

This study collected umbilical cord blood from 44 newborns whose mothers carry the sickle cell trait, to help researchers better understand the disease and develop ways to modify and preserve these cells in the lab. The goal was not to treat patients directly, but to gather sampl…

This study looked at why some people with Alzheimer's or frontotemporal dementia lose awareness of their own condition (anosognosia). Researchers used brain scans and EEG to measure how the brain reacts to mistakes and emotional signals in 77 participants. The goal was to find br…

This study looked at how bariatric surgery affects taste receptors and taste perception in 20 people with obesity. Researchers measured changes in taste before and 6 months after surgery. The goal was to understand why taste changes happen after weight-loss surgery, not to treat …

This study followed 38 adults who survived severe H1N1 flu that caused lung failure. Researchers compared those who needed a machine to oxygenate their blood (ECMO) with those who did not. They measured lung function, quality of life, and mental health at least 9 months after lea…

This study tested a new, non-invasive way to monitor chemotherapy effects in 16 people with advanced colorectal cancer. Researchers measured special substances in urine samples taken before and after treatment to see if they could track cancer activity without blood draws or scan…

This study looked at how the brain's wiring relates to impulsive behavior in people with Tourette syndrome. Researchers used MRI scans to compare brain activity and connections in 80 patients (some treated, some not) and 40 healthy volunteers. The goal was to find the brain areas…

This study followed 787 people in the Democratic Republic of the Congo, including Ebola survivors and their close contacts. Researchers aimed to learn about long-term health problems, how the immune system responds, and whether the virus stays in the body. The goal is to improve …

This study measured how many people in France had been infected with SARS-CoV-2 by testing their blood for antibodies. Nearly 97,000 participants from existing health studies provided samples to track infection rates and understand what factors influenced who got sick. The goal w…

This study looked at fat tissue from the belly and thigh in 20 healthy women to see if the cells are different. Researchers want to understand why belly fat is linked to health problems while thigh fat may be protective. The study did not test any treatment—it only observed and c…

This study looked at gene activity in the uterine lining during menstruation to understand why humans have periods while some other primates do not. Researchers collected menstrual fluid from 21 healthy women using a silicone cup, a non-invasive method. The goal was to learn more…

This study looked at how blood flow and brain activity are linked in people with CADASIL, a rare genetic disease that causes small strokes. Researchers used MRI and EEG scans to measure these connections in 60 adults. The goal was to better understand the disease, not to test a n…

This study looked at how COVID-19 spread among patients and healthcare workers in four hospitals in Bamako, Mali. Researchers used molecular tests to find active infections and blood tests to check for past infections and immunity. The goal was to understand infection rates, incl…

This study looked at how two brain regions—the cerebellum and striatum—communicate in people with dystonia caused by ADCY5 or PRRT2 gene mutations. Researchers used MRI scans and mild brain stimulation to compare brain activity among patients and healthy volunteers. The goal was …

This study looked at how people with dystonia, essential tremor, or Parkinson's disease adapt their eye movements compared to healthy volunteers. Researchers used a special eye-tracking device to measure changes before and after a task. The goal was to learn more about how the ce…

This study measured COVID-19 antibodies in over 2,800 primary care health workers (like doctors, pharmacists, and dentists) and their household members in France. The goal was to understand how many had been exposed to the virus and how their immune systems responded. Results hel…

This study followed over 3,400 children born very early (before 35 weeks) to understand their long-term health and development. At age five and a half, researchers checked for movement, thinking, and behavior problems. The goal is to learn how premature birth affects children as …

This study looked at how spinal nerves work in people recently diagnosed with ALS compared to healthy volunteers. The goal was to find early signs of nerve damage that could help doctors diagnose ALS sooner and track how the disease progresses. Researchers used painless electrica…

This study looked at how people with cervical or myoclonus dystonia experience a sense of control over their movements. Researchers used computer tests and brain scans to find links between movement perception, symptom severity, and brain structure. The goal was to better underst…

This study followed 216 survivors of the 2015 Paris terrorist attacks for up to 6 years, using brain scans to see how their brains process traumatic memories. Researchers compared them to people who were not at the attacks. The goal was to understand why some people develop PTSD …

This study looked at air quality inside airplane cabins during smoke, fume, or odor events and how these events might affect the health of flight crew members. Researchers tested 357 crew members using cognitive and physical exams to check for neurological symptoms. The goal was …

This completed study looked at how the cerebellum, a part of the brain that helps coordinate movement, influences brain plasticity in people with dystonia (a movement disorder causing muscle spasms) and in healthy volunteers. Researchers used mild brain stimulation to temporarily…

This study looked for new genes that cause intellectual disability, a condition affecting 2-3% of people. Researchers used advanced DNA tools to analyze 8500 participants, including patients and their healthy siblings. The goal was to find the genetic cause and better understand …

This study looked at how people with alcohol use disorder (AUD) organize words and ideas in their memory compared to healthy individuals. Researchers tested 41 participants using word association tasks and brain function tests. The goal was to see if changes in these mental netwo…

This study looked at how radiation therapy for childhood brain tumors affects memory and brain structure. Researchers used brain scans and memory tests in 60 children, teens, and young adults who had been treated for brain cancer. The goal was to better understand which parts of …

This study looked at 52 people with ALS and healthy volunteers to find out why some patients have unnoticed sensory problems. Researchers used brain scans and electrical recordings to see how sensory changes affect brain activity. The goal was to link these changes to damage in b…

This study tested a new way to measure apathy (lack of motivation) using video recordings and body sensors. Researchers observed 66 healthy volunteers and patients with brain conditions like frontotemporal dementia or depression during a structured real-life scenario. The goal wa…

This study created the first French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected clinical and genetic information from 28 children and adults to better describe these conditions and estimate how common they are…

This study looked at 43 people in a coma after severe brain injury. Researchers used MRI scans to measure brain network activity and compared it with standard consciousness tests. The goal was to see if certain brain patterns could predict whether a patient would wake up.

This pilot study tested whether it is possible to quickly analyze the genetic makeup of tumors from 24 adults with advanced colorectal cancer or soft tissue sarcoma. The main goal was to see how long it takes to get a complete genetic report back to the doctor after receiving a s…

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS). The goal was to see if these changes happen early in the disease and differ between MS types. Participants had one eye exam at the …

This study looked at how skin cells from 30 people with recessive dystrophic epidermolysis bullosa (RDEB) grow and repair wounds. RDEB is a rare genetic condition that causes fragile skin and painful blisters. Researchers took small skin samples to study the cells in a lab, aimin…

This study looked at how energy levels in the brain change as Huntington disease progresses. Researchers used a special type of MRI to measure energy-related chemicals in the brains of 50 adults with Huntington disease. The goal was to better understand the disease, not to test a…

This study followed nearly 27,000 pregnant women during the 2016 Zika outbreak in French Caribbean territories. Researchers collected medical information to understand how Zika infection during pregnancy affects the baby, including risks of microcephaly and other brain problems. …

This study examined the DNA of over 2,300 adults who experienced sudden cardiac arrest outside the hospital. Researchers looked for specific genetic variations that might increase the risk of sudden death. The goal is to better identify people at high risk so that future preventi…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans, thinking tests, and mild magnetic pulses to measure brain activity. The goal was to learn why some teens see their…

This study followed 324 people who had close contact with a confirmed COVID-19 case to see how long the virus stays in their nose and throat. Researchers tested participants multiple times over 12 days and tracked any symptoms. The goal was to understand how many exposed people b…

This study looked at whether energy problems in brain cells can predict nerve damage in people with multiple sclerosis (MS). Researchers used special MRI scans to measure energy use in the brains of 40 MS patients and 15 healthy volunteers. They tracked changes over two years to …

This study looked at tiny lymph vessels in the brain covering (dura) of 40 women with idiopathic intracranial hypertension (IIH), a condition causing severe headaches and vision loss due to high pressure inside the skull. Researchers used a special MRI technique to compare these …

This study followed 364 adults with severe stroke who needed a breathing machine in the ICU. Researchers measured their recovery and disability levels at 3 months and 1 year after ICU admission. The goal was to better understand what happens to these patients over time, not to te…

This study looked at whether advanced genetic testing (called NGS) can be done quickly enough to help guide treatment choices for people with advanced soft-tissue sarcoma. About 600 adults with this rare cancer took part. The goal was to see if using genetic information to pick t…

This study involved 40 adults with spinocerebellar ataxia types 2 or 7, a rare brain disease that affects movement. Researchers used walking tests, balance checks, and brain scans over one year to find reliable markers of the disease. The goal was to prepare for future trials of …

This study collected blood samples from over 2,200 people with Alzheimer's or other dementias, plus healthy volunteers, to search for genes linked to these diseases. Researchers aimed to identify new genetic causes and better understand how genes affect disease risk and progressi…

This study looked at DNA from 2500 people, including those with Parkinson's disease and healthy controls, to find genetic mutations linked to the condition. Researchers focused on genes like parkin, DJ-1, PINK1, and LRRK2. The goal was to better understand the disease and improve…

This study tested a new, highly sensitive ultrasound technique to map brain activity during surgery. Researchers compared it to standard methods in 23 adults with brain tumors or lesions. The goal was to see if this low-cost, real-time imaging could help surgeons identify importa…

This study tested a decision aid for women with a less active ectopic pregnancy (a pregnancy outside the womb that is not growing quickly). 109 women and their doctors used the tool and then answered questions about how helpful and clear it was. The goal was to see if the tool he…