Institut National De La Santé Et De La Recherche Médicale, France

This study tested whether a combination of school education for teens and parents, training for doctors, and offering the vaccine at school could increase HPV vaccination rates. Over 30,000 French adolescents aged 11-14 took part across 90 towns. The goal was to see if these effo…

This early-stage trial tested a vaccine called PRIMVAC, designed to protect pregnant women from malaria. Researchers gave three different doses to 68 healthy adults in France and Burkina Faso to check for safety and immune response. The vaccine uses two different adjuvants (Alhyd…

This study measured how effective the seasonal flu vaccine was in preventing flu among adults hospitalized in France during the 2012-2013 flu season. Researchers compared flu cases in vaccinated and unvaccinated patients to calculate vaccine effectiveness. The goal was to underst…

This study tested an H1N1 flu vaccine in 110 pregnant women to see if it is safe and helps their bodies build protection against the virus. Participants received two vaccine doses and had blood samples taken, including from the umbilical cord after birth. The goal was to measure …

This early-stage study tested a DNA vaccine for chronic hepatitis B in 10 patients who had not responded to standard treatments. The main goal was to see if the vaccine was safe and could help the immune system fight the virus. The study was completed, but results on effectivenes…

This study tested the drug rapamycin in 44 adults with Inclusion Body Myositis, a rare muscle disease that causes progressive weakness. The goal was to see if rapamycin could stabilize muscle strength and improve immune function. Participants received either rapamycin or a placeb…

This study looked at 100 newborns with suspected or confirmed yeast infections (candidiasis) to compare two antifungal drugs: fluconazole (the current standard) and micafungin. The goal was to see if micafungin works just as well and is as safe as fluconazole. Researchers also st…

This study looked at whether teaching people with type 2 diabetes about healthy eating and exercise, plus checking in with them every three months, helps control their blood sugar better than no follow-up. 398 adults took part. After one year, researchers compared blood sugar lev…

This study tested a special oil called triheptanoin in children with Alternating Hemiplegia of Childhood, a rare condition causing temporary paralysis. Ten children took the oil or a placebo in a crossover design to see if it reduced the number of paralytic episodes. The goal was…

This study aimed to create a simple scoring system to help doctors diagnose tuberculosis (TB) in hospitalized children aged 2 to 59 months who have severe acute malnutrition. Researchers in Uganda and Zambia tested different diagnostic methods in 603 children. The goal was to dev…

This study tested whether a smartphone app called Apneal can accurately diagnose sleep apnea in adults. About 491 participants used the app during a standard overnight sleep test. The goal was to see if the app could correctly identify the severity of sleep apnea, from mild to se…

This study looked at whether caffeine can help people with a rare genetic condition called ADCY5-related dyskinesia, which causes uncontrollable movements. Fifteen patients took caffeine and reported how it affected their symptoms through phone interviews. The goal was to see if …

This study tested whether deep brain stimulation of a specific brain area (the mesencephalic locomotor region) can help improve walking and balance problems in people with advanced Parkinson's disease. Six participants received the stimulation in a randomized, double-blind, cross…

This study tested whether online therapy (blended cognitive behavioral therapy) works as well as traditional face-to-face therapy for adults with major depression. 105 participants were split into two groups to compare effectiveness and cost. The goal was to see if internet-based…

This study tested a device called MyoRegulator to see if it can safely reduce leg muscle tightness (spasticity) in people who had a stroke. 44 stroke survivors with leg stiffness received either real or sham treatment for 5 days. The goal was to measure changes in muscle tightnes…

This study tested a program called 'Choizitaconso' that teaches people with alcohol use disorder skills to control their drinking and reduce related harms. 110 adults took part, and researchers measured alcohol-related problems and quality of life before and after the program. Th…

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS). The goal was to see if these changes happen early in MS and differ between types of the disease. Participants had one eye exam at t…

This study looked at how brain energy levels change as Huntington disease progresses. Researchers used a special MRI technique to measure energy-related chemicals in the brains of 50 people with Huntington disease. The goal was to understand the disease better, not to test a trea…

This study looked at how COVID-19 spread among patients and healthcare workers in four hospitals in Bamako, Mali. Researchers tested 450 people for the virus using nose swabs and also checked for antibodies to see who had been infected before. The goal was to understand infection…

This study looked at how people with dystonia, essential tremor, and Parkinson's disease adapt their eye movements. Researchers used a video-based eye tracker to measure changes before and after a task. The goal was to learn more about how the cerebellum works in these conditions…

This study looked at whether advanced genetic testing (called NGS) can be done quickly and reliably for people with advanced soft-tissue sarcoma. It included 603 adults whose tumors could not be removed by surgery or had spread. The goal was to see if using genetic information to…

This study looked at air quality inside airplane cabins during smoke, fume, or odor events and how those events might affect the brain health of flight crew members. Researchers tested 357 crew members using memory, attention, and touch tests after flights with and without fume e…

This study followed 364 stroke patients who needed a breathing machine in the intensive care unit (ICU). Researchers wanted to see how well these patients recovered 3 months and 1 year later, using a disability scale. The goal was to better understand what happens to people after…

This study tested a decision aid to help women with less active ectopic pregnancy choose their treatment. Researchers enrolled 109 women across 16 French hospitals. Participants and their doctors used the tool and then filled out questionnaires about how helpful and clear it was.…

This study looked at how a small genetic difference (called TaqIB) affects the way HDL, or 'good' cholesterol, works in the body. Researchers compared two groups of healthy men—those with one version of the gene versus another—to see how well their HDL helped remove cholesterol f…

This study looked at 52 people with ALS and healthy volunteers to find out why some patients have unnoticed sensory issues. Researchers used brain imaging and electrical recordings to see how sensory changes affect brain activity. The goal was to link these changes to brain struc…

This study followed 787 people in the Democratic Republic of the Congo, including Ebola survivors and their close contacts. Researchers wanted to learn about the long-term health problems survivors face, how their immune systems respond over time, and whether contacts can get inf…

This study tested a new ultrasound technique to detect blood flow inside solid bone, which current methods cannot do. Nineteen healthy adults had their forearm and shin scanned while blood flow was changed using a blood pressure cuff or by changing body position. The goal was to …

This study looked at how blood flow and brain activity work together in people with CADASIL, a rare genetic disease that affects small blood vessels in the brain. Researchers used MRI scans and EEG recordings to measure these interactions in 60 participants. The goal was to bette…

This study looked at skin cells from 30 people with recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic condition that causes severe blistering. Researchers measured how well skin cells called keratinocytes and fibroblasts can grow and repair wounds. The goal was to…

This study looked at how people with cervical and myoclonus dystonia perceive their own movements, known as the sense of agency. Researchers used computer tests and brain imaging to understand the link between movement perception, symptom severity, and brain structure. The goal w…

This study looked at the brain activity of 43 people in a coma after severe brain injury. Researchers used MRI scans to see how different parts of the brain communicate, especially the default-mode network, which is active when we are awake and daydreaming. The goal was to see if…

This study followed 919 pregnant women in three Paris hospitals during the 2009 H1N1 flu pandemic. Researchers measured how many women caught the flu and how it affected their pregnancy outcomes. They also checked the safety of the flu vaccine. The goal was to better understand t…

This study looked at how two types of cognitive behavioral therapy (CBT) affect brain activity in people with obsessive-compulsive disorder (OCD). 35 adults with OCD and checking symptoms received 15 therapy sessions, and their brain scans were taken before, during, right after, …

This study followed 216 survivors of the 2015 Paris terrorist attacks and a control group for up to 6 years. Researchers used brain scans to see how trauma changes the brain's ability to suppress unwanted memories, which is key to understanding PTSD. The goal was to learn how the…

This early study tested whether a painless, non-invasive brain stimulation technique called tDCS could change the brain's control over the diaphragm—the main muscle for breathing. Twelve healthy men received three types of stimulation (anodal, cathodal, or placebo) on different d…

This early-stage trial tested a single inhaled dose of a drug called FLAMOD in 46 healthy adults to see if it is safe and can activate the immune system in the lungs. The goal is to find a dose that could help prevent or fight pneumonia. No treatment was given to sick patients; t…

This study took small tissue samples from 16 people with and without inflammatory bowel disease (IBD) during routine colonoscopies. Researchers grew these samples into mini-organs called organoids in the lab. The goal was to see if they could reliably create these organoids and t…

This study collected umbilical cord blood from 44 newborns whose mothers had the sickle cell trait. The goal was to study the blood cells and develop better ways to prepare, gene-modify, and preserve them for future treatments. No direct treatment was given to participants; the w…

This early study tested whether a treatment could improve brain energy use in people with early Huntington disease. Ten participants had special MRI scans to measure brain metabolism at rest and during visual stimulation. The goal was to see if the treatment helped brain cells wo…

This study tested how quickly doctors could get a detailed genetic report from a patient's tumor sample. It included 24 adults with advanced soft-tissue sarcoma or colorectal cancer. The main goal was to measure the time from receiving the sample to sending the report to the doct…

This study measured how many people in France had been infected with SARS-CoV-2 by testing their blood for antibodies. Nearly 97,000 volunteers from existing health studies took part. Researchers also looked at how long antibodies lasted and what factors influenced infection risk…

This study looked at how radiation therapy for childhood brain tumors affects memory and thinking. Researchers used brain scans and memory tests in 60 children, teens, and young adults who had been treated for cancer. The goal was to understand which parts of the brain are most a…

This study tested a new, highly sensitive ultrasound technique to map brain activity during surgery in 23 adults with brain tumors or lesions. The goal was to see if this method could show which brain areas are active, helping surgeons avoid damaging important regions. The approa…

This study looked at whether certain proteins called beta-arrestins can help predict how well people with major depression will respond to the antidepressant venlafaxine. Researchers measured these proteins in the blood of 67 participants before and during treatment, and tracked …

This study looked at bacteria living in the small intestine and colon of 90 adults—some lean, some with obesity, and some with both obesity and type 2 diabetes. Researchers collected samples during routine endoscopy or colonoscopy to compare these gut bacteria with those found in…

This study followed more than 3,400 children born very early (before 35 weeks) from birth up to age 5 and a half. Researchers checked their motor skills, thinking abilities, and behavior to see how these relate to how early they were born. The goal was to learn more about the lon…

This study used advanced MRI to look at tiny lymphatic vessels in the brain's lining of people with idiopathic intracranial hypertension (IIH), a condition causing severe headaches and vision loss. Researchers compared 20 IIH patients with 20 healthy volunteers to see if these ve…

This study looked at how Parkinson's disease changes a person's ability to sense time. Researchers tested 40 people—some with Parkinson's and some healthy—by measuring their eye movements as they anticipated when a target would appear. Patients were tested both on and off their r…

This study looked at how people with ALS start walking and keep their balance. Researchers compared ALS patients with and without balance issues, plus healthy volunteers, using movement tests and brain scans. The goal was to understand why some ALS patients have trouble with bala…

This study looked at adults who received low-dose radiation to the brain as children for a harmless skin growth (hemangioma). Researchers tested their memory, thinking, and other brain functions to see if the radiation caused any long-term problems. The goal was to understand ris…

This study tested a new way to monitor chemotherapy effects in 16 people with advanced colorectal cancer. Instead of repeated blood draws or scans, researchers measured special substances in urine samples collected daily before and after treatment. The goal was to see if these ur…