Institut National De La Santé Et De La Recherche Médicale, France

This early-stage trial tests a one-time treatment for recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic condition causing fragile, blistering skin. Doctors take a small piece of the patient's skin, fix the faulty gene in a lab, grow it into a healthy sheet, and gr…

This study looks at whether using different personal care products for 5 days can reduce the amount of certain chemicals (like phthalates and phenols) in the urine of 107 women aged 18-30. Participants will use substitute products provided by the researchers. The goal is to see i…

This study looks at whether certain slow brain waves in the prefrontal cortex can be a sign of social anxiety. Researchers will measure brain activity in 30 people with social anxiety disorder while they wait to give a speech. The goal is to better understand the brain's role in …

This study looks at the chemicals and germs that women working on dairy farms in France may be exposed to through their skin or breathing. Researchers will measure these substances in urine, hair, and feces of about 60 women, as well as in cow hair and air samples. The goal is to…

This study planned to compare two forms of a medicine (PGE2) used to prepare the cervix and start labor in pregnant women at full term. One was a removable insert and the other a gel placed inside the vagina. The study was withdrawn before any participants were enrolled, so no re…

This study aims to find a set of markers—from genes, immune system, and brain scans—that can predict how severe multiple sclerosis (MS) will become. Researchers will follow 120 people with MS and their siblings who also have the disease. The goal is not to test a new treatment, b…

This study was designed to test a new computer-based tool that uses pictures of food to measure how much pleasure and motivation people with major depression feel. The goal was to compare these responses between depressed patients and healthy volunteers to better understand depre…

This study aims to create a reference map of genetic variations found in the general French population. By analyzing DNA from 10,000 volunteers, researchers hope to better identify which genetic changes are likely to cause disease. This will help doctors filter out common, harmle…

This study looks at 1256 adults aged 40 to 80 with type 2 diabetes and heart muscle problems. Researchers want to find out if diabetic cardiomyopathy is a unique disease by using advanced tests like imaging and blood analysis. No new treatments are being tested; the goal is to be…

This study looks at how brain injuries lead to problems with thinking, memory, and perception. Researchers will use brain scans like MRI and EEG on 1,500 adults with brain lesions to see which brain areas are involved. The goal is to better understand these cognitive issues, not …

This study follows over 10,000 healthy adults aged 50-75 for at least 10 years to understand how heart rate and blood pressure changes are linked to heart disease, stroke, and sudden death. Participants undergo tests to measure heart rate regulation and artery stiffness. The goal…

This study aimed to see if teaching people who inject drugs to wash their hands and giving them a single-use hand sanitizer could lower their risk of skin abscesses. It was designed as a cluster trial comparing standard harm reduction services with or without the hand-washing edu…

This study looks at 60 adults with resistant hypertension—high blood pressure that doesn't improve even with multiple medications. Researchers measure artery stiffness using a simple, non-invasive test to see if it can help identify patients who aren't taking their drugs as presc…

This study follows 340 people with vascular Ehlers-Danlos syndrome (vEDS), a rare genetic condition that weakens blood vessels and organs. Researchers will track complications like artery tears, digestive issues, and pregnancy risks to better understand how the disease progresses…

This study follows 650 children and adults with LPAC syndrome, a rare condition that causes repeated gallstones even after gallbladder removal. Researchers will collect medical history, lab results, and imaging data over 5 years to describe the disease's full range of symptoms an…