Institut National De La Santé Et De La Recherche Médicale, France

This early-stage trial tested a vaccine called PRIMVAC, designed to prevent malaria during pregnancy. Researchers gave three different doses to 68 healthy adults in France and Burkina Faso, using two different adjuvants to boost immune response. The main goal was to check safety …

This phase 2 study tested a non-adjuvanted H1N1 flu vaccine in 110 pregnant women to see if it is safe and triggers a good immune response. Participants received two doses of the vaccine and were monitored for side effects. The goal is to protect both mothers and their babies fro…

This early-stage study tested a new whooping cough vaccine given as a nasal spray. 48 healthy adult men received either the vaccine or a placebo to check safety and immune response. The goal is to develop a single-dose vaccine that can protect infants from birth, before they get …

This early-phase study tested a DNA vaccine in 10 adults with chronic hepatitis B who had not responded to standard treatments. The goal was to see if the vaccine is safe and can help the immune system fight the virus. The study focused on safety and immune response, not on curin…

This study tested a new malaria vaccine in 66 healthy adults from Europe and Africa. The vaccine aims to teach the body to fight the malaria parasite. Researchers checked for side effects and measured immune responses after three doses over six months.

This study tested a higher dose of a new nasal vaccine (BPZE1) for whooping cough in 54 healthy adults aged 18-32. The goal was to see if the higher dose is safe and helps the vaccine take hold in the nose to trigger protection. Researchers monitored side effects and checked if t…

This study looked at whether combining school education, doctor training, and offering the vaccine at school can increase HPV vaccination among French adolescents aged 11 to 14. Over 30,000 teens from 90 towns took part. The goal was to see if these efforts make more teens get th…

This study tested a flu vaccine (H1N1) in 122 kidney transplant patients to see if it is safe and helps their immune system fight the flu. Participants were adults who had a kidney transplant at least 6 months ago and were on stable immunosuppressive drugs. The vaccine was given …

This study tested a gene therapy for children with early-onset metachromatic leukodystrophy (MLD), a rare and severe brain disease. Five children aged 6 months to 5 years received direct injections of a harmless virus carrying a working gene into their brains. The goal was to see…

This early-phase trial tested the drug artesunate, usually used for malaria, in 20 people with Friedreich ataxia. The goal was to find a safe dose that might improve how cells handle iron, a key problem in this disease. Researchers measured a biological marker in blood cells to s…

This early-phase trial tested whether injecting a man's own bone marrow stem cells into the penis could help restore erections after prostate cancer surgery. The study included 18 men who had normal erections before surgery but developed erectile dysfunction due to blood vessel d…

This pilot study tested whether triheptanoin oil, a special fat taken by mouth, can reduce the number of sudden paralytic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder. Ten participants aged 15 and older with confirmed ATP1A3 mutation…

This study tested whether giving acetaminophen (paracetamol) early after birth can help close a blood vessel (ductus arteriosus) that often stays open in extremely preterm infants. Over 800 babies born between 23 and 28 weeks of pregnancy took part across Europe. The goal was to …

This study tested a special oil called triheptanoin in 100 people with early Huntington's disease. Half took the oil daily for 6 months, the other half took a placebo oil. The goal was to see if the oil could slow brain shrinkage and improve symptoms. After 6 months, everyone cou…

This phase 2 trial tested triheptanoin oil in 20 people with GLUT1 deficiency syndrome, a rare genetic disorder that prevents sugar from fueling the brain. The goal was to see if this special oil could reduce seizures and abnormal movements. Researchers monitored participants for…

This study tested the antiviral drug favipiravir in 126 people with Ebola in Guinea. Participants received high doses of the drug for 10 days. The goal was to see if it could lower the death rate. Results suggested a possible benefit for patients with low to moderate virus levels…

This large, completed trial tested several potential COVID-19 treatments in over 1,500 hospitalized adults across Europe. Earlier drugs like remdesivir and hydroxychloroquine were dropped after showing no benefit. The current phase is testing a new antibody combination called AZD…

This study tested three drugs (Xenbilox, Tahor, and Resveratrol) in 12 adults with a rare inherited form of spastic paraplegia called SPG5. The goal was to lower levels of harmful oxysterols, which are toxic byproducts of cholesterol that damage nerve cells. Each participant took…

This study tested a vaccine called Bilhvax, given alongside a standard treatment (praziquantel), to see if it could delay the return of schistosomiasis (a parasitic infection) in children aged 6 to 9 in Senegal. The vaccine was given as three shots plus a booster one year later. …

This study tested a drug called anakinra in 24 children and young adults (ages 2-20) with severe systemic juvenile idiopathic arthritis that did not respond well to steroids. For the first month, half received anakinra and half received a placebo, then all received anakinra for 1…

This study looked at 100 newborns with suspected or confirmed yeast infections (candidiasis) to compare two antifungal drugs: fluconazole (the current standard) and micafungin. The goal was to see if micafungin works as well and is as safe as fluconazole. Researchers also studied…

This study tested the drug rapamycin in 44 adults with Inclusion Body Myositis, a rare muscle disease that causes progressive weakness. The goal was to see if rapamycin could slow the loss of muscle strength. Participants received either rapamycin or a placebo, and their muscle s…

This study tested a new way to help broken bones that are taking too long to heal. Doctors took a small sample of the patient's own bone marrow, grew the stem cells in a lab, and then placed them with a special bone-like material at the fracture site. The goal was to see if this …

This early study tested whether a 3-week course of sitagliptin, a diabetes drug, is safe for people with liver cancer (HCC) who are having part of their liver removed. Only 14 patients took part. The goal was to see if the drug could help the immune system attack the tumor by pro…

This study tested whether giving extra support—like cooking classes, motivational talks, and financial help for physical activity—to overweight teens from less advantaged backgrounds helps them manage their weight as well as standard care helps teens from more advantaged backgrou…

This study looked at whether regular follow-up visits with nurses and dietitians help people with type 2 diabetes manage their condition better. 398 adults with type 2 diabetes first received a week of education on diet and exercise. Then half were assigned to frequent check-ins …

This study enrolled 603 severely malnourished children in Uganda and Zambia to develop a score that helps doctors decide whether to treat tuberculosis. Researchers tested children with chest X-rays, lab tests, and symptom checks. The goal is to create a simple, accurate tool to d…

This study tested if a smartphone app called Apneal can accurately diagnose sleep apnea in adults. Nearly 500 participants used the app during a standard overnight sleep test. The goal was to see if the app could correctly identify the severity of sleep apnea, from mild to severe…

This study tested whether adding a rapid tuberculosis (TB) test to standard care for children hospitalized with severe pneumonia could reduce deaths. Over 2,500 children aged 2 to 59 months in six high-TB countries were enrolled. The test, called Xpert MTB/RIF Ultra, was done on …

This study tested whether a brain scan (fMRI) could detect early signs of Parkinson's disease by measuring activity in a small brain area called the superior colliculus, which processes visual information. Researchers compared 23 newly diagnosed Parkinson's patients with healthy …

This study looked at whether measuring a protein called EG-VEGF in the blood of pregnant women between 14 and 18 weeks could help predict pre-eclampsia or intrauterine growth restriction (poor fetal growth). Researchers enrolled 142 women and measured EG-VEGF levels, comparing th…

This study tested whether whole genome sequencing (WGS) can find more genetic causes of intellectual disability than current standard tests. Researchers compared WGS to usual methods in 3825 children and adults with unexplained intellectual disability. The goal was to see if WGS …

This study tested a personalized program combining physical activity, cognitive training, and nutrition advice to prevent mobility disability in 210 older adults who were frail or pre-frail. Participants were 60+ and lived independently. The goal was to see if this multi-domain a…

This study tested whether promoting a free web and mobile tool called StopBlues could reduce suicide and psychological distress in the general population. Over 100,000 adults in France took part. Local authorities either promoted the tool, promoted it with help from doctors, or d…

This study tested whether a patient navigator—someone who helps guide people through the healthcare system—could increase participation in colorectal cancer screening. Nearly 29,000 French adults aged 50-74 who had not been screened were included. The goal was to see if this appr…

This study looked at how well the seasonal flu vaccine works in adults who are hospitalized with severe flu-like illness. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine reduced confirmed flu cases. The goal is …

This study tested a simple method to help C-section babies develop a healthier gut. Researchers gave newborns a swab coated with their mother's vaginal fluids right after birth. The goal was to see if this could restore the natural gut bacteria that babies usually get during a va…

This study measured how effective the seasonal flu vaccine was at preventing flu in adults who were hospitalized with flu-like symptoms. Researchers compared the number of lab-confirmed flu cases between vaccinated and unvaccinated patients across a network of French hospitals. T…

This study tested whether a blend of online and in-person therapy (called blended CBT) works as well as standard face-to-face therapy for adults with major depression. 105 participants were randomly assigned to either blended CBT or usual care. Researchers measured depression sym…

This study tested whether a special video game (serious game) could help people with Parkinson's disease who have trouble walking and balancing. Twenty-five patients played either a movement-based game or a placebo game. Researchers measured how fast they could stand up, walk, an…

This study tested a device called MyoRegulator® to see if it can reduce muscle stiffness (spasticity) in the lower leg after a stroke. 44 adults who had a stroke at least 6 months earlier took part. Half received real treatment and half received a sham (fake) treatment for 5 days…

This small pilot study looked at whether caffeine can ease involuntary movements in people with a rare genetic condition called ADCY5-related dyskinesia. Fifteen participants took caffeine and reported how much their symptoms improved. The goal was to see if at least 40% of peopl…

This study tested whether a special dietary oil called triheptanoin can help adults with McArdle disease (a rare sugar metabolism disorder) exercise better. Twelve participants took triheptanoin or a placebo for two weeks each, then switched. Researchers measured heart rate and f…

This study tested whether an 8-week mindfulness program could reduce anxiety in 168 older adults who have memory concerns but normal cognitive test scores. Participants were randomly assigned to either mindfulness training or a health education program. The goal was to see if min…

This study tested a program called "Choizitaconso" that teaches people with alcohol use disorder how to control their drinking and reduce harm. About 110 adults took part, learning skills to manage their alcohol use and avoid negative consequences. The goal was to see if the prog…

This study tested whether combining a drug called galantamine with a specific cognitive training program could improve thinking skills in adults aged 35-70 who had a first stroke 3 months earlier. 47 participants received either the drug or a placebo, plus brain training, and wer…

This study looked at 80 pregnant women with too much amniotic fluid (polyhydramnios) causing discomfort. Researchers compared two drainage methods: manual syringe removal versus continuous suction. The goal was to see which technique causes less pain and is safer for both mother …

This study tested whether a measles vaccine could help control eczema (atopic dermatitis) in adults. Researchers gave 20 adults with moderate-to-severe eczema either the measles vaccine or a placebo and tracked their symptoms for 45 days. The goal was to see if the vaccine could …

This study looked at whether taking weekly dance classes for 8 months can help people with Huntington's disease and their caregivers. Researchers measured movement control, emotion, quality of life, and brain changes using tests and MRI scans. The goal was to see if dance trainin…

This study tested whether a mild electrical current applied to the back of the head (cerebellum) can reduce shaking in people with essential tremor. Sixteen adults whose usual treatments weren't working well took part. Researchers measured tremor changes using rating scales and m…

This study tested a gentle electrical stimulation applied to the spine in 18 people with primary orthostatic tremor, a condition that causes leg shaking when standing. The goal was to see if this stimulation could help them stand longer without support. The approach is non-invasi…

This study tested whether deep brain stimulation of a specific brain region could improve walking and balance problems in people with advanced Parkinson's disease. Six participants received the stimulation in a randomized, double-blind crossover design. The goal was to see if thi…

This completed study looked at how the brain processes movement, thoughts, and emotions in people with myoclonus dystonia, a rare condition causing jerky movements and muscle spasms. Researchers used MRI scans and psychological interviews with 47 participants (patients and health…

This study measured how children with and without autism look at faces and body movements compared to objects. Researchers tracked eye movements and pupil changes to understand social attention. The goal was to find markers that could help monitor development and response to ther…

This study tested whether motivational interviewing—a therapy that helps people find their own reasons to change—can shift brain activity and food choices in people with food addiction. 56 participants, including those with and without obesity, underwent brain scans while making …

This early-stage trial tested a single inhaled dose of FLAMOD, a protein from bacteria, in 46 healthy adults. The goal was to see if it is safe and can activate the immune system in the lungs. Researchers are looking for the best dose that triggers immune responses without causin…

This completed study tested a new laser-based device (Laser Doppler Vibrometer) to measure artery stiffness in 100 people with high blood pressure. The goal was to see if this painless, non-invasive method works as well as current standard techniques. The study did not test any t…

This completed study created a national registry in France for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affe…

This study uses fMRI brain scans to understand how shared cultural memories, like those from World War II, influence how individuals remember personal experiences. Researchers will scan 27 healthy adults while they recall pictures from a museum tour. The goal is to see which brai…

This study uses advanced MRI scans to look at energy use in the brains of people with multiple sclerosis (MS) and healthy volunteers. The goal is to see if early energy problems in brain cells can predict nerve damage over two years. Researchers hope this will help understand how…

This pilot study tested whether wearable sensors can measure apathy in people with frontotemporal dementia and healthy volunteers. Researchers used video recordings and motion sensors to track behaviors like lying, sitting, and energy use. The goal was to see if this technology c…

This study used special brain scans (PET imaging) to measure amyloid plaques in 60 people with Alzheimer's disease or related conditions like posterior cortical atrophy and logopenic progressive aphasia. The goal was to understand how age influences the amount of amyloid in the b…

This study tested whether special sensors could measure certain molecules in urine to track how cancer treatment is working. Researchers collected urine samples from 32 people with metastatic colorectal cancer and healthy volunteers over two days. The goal was to see if these mol…

This study looked at 8500 people with intellectual disability to find new genes that might cause it. Researchers used advanced DNA tools to compare patients and their healthy siblings. The goal was to identify unknown genetic causes and improve future diagnosis.

This study followed 324 people who had close contact with someone confirmed to have COVID-19. Researchers took nose swabs and tracked symptoms for 12 days to see how long the virus could be detected. The goal was to understand how many exposed people become spreaders, even withou…

This completed study looked at 40 people with spinocerebellar ataxia types 2 and 7, a rare brain disease that affects movement. Researchers used MRI scans and lumbar punctures over one year to track changes in the brain and body. The goal was to find reliable markers that could b…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This completed study looked for genetic changes linked to autism spectrum disorder. Researchers analyzed DNA from over 1,600 participants to find mutations in genes related to brain cell communication. The goal was to better understand the biology of autism and identify potential…

This completed study enrolled nearly 97,000 people from existing French health cohorts to track how many had been infected with SARS-CoV-2. Researchers used blood tests to detect antibodies and studied how infection rates varied across different groups. The goal was to better und…

This study looked at how two different types of cognitive behavioral therapy (CBT) affect brain activity in people with obsessive compulsive disorder (OCD). 35 adults with checking symptoms and moderate-to-severe OCD received 15 therapy sessions. Researchers used brain scans befo…

This study looked at breathing problems in 70 people with severe multiple sclerosis (MS). Participants underwent sleep studies and lung function tests to check for diaphragm weakness. The goal was simply to describe these breathing issues, not to test a treatment. The results may…

This study used MRI scans and memory tests to see how radiation therapy affects memory in children, adolescents, and young adults who were treated for brain cancer. Researchers looked at the hippocampus and cerebellum, two brain areas important for memory and learning. The goal w…

This study looked at brain activity in 43 people in a coma after severe brain injury. Researchers used MRI scans to see how different brain regions communicate, aiming to understand what happens in the brain during coma and as people wake up. No treatment was given; the goal was …

This study tested two types of non-invasive brain stimulation (called paired associative stimulation) to see if they could help improve hand movement in people who had a stroke. 81 participants (60 stroke survivors and 24 healthy volunteers) took part. The main goal was to unders…

This study looked at the DNA of 2500 people, including those with Parkinson's disease and healthy volunteers, to find genetic changes linked to the condition. Researchers focused on specific genes like parkin, DJ-1, PINK1, and LRRK2. The goal was to better understand the disease'…

This study looked at how brain energy changes in people with Huntington disease. Researchers used a special MRI technique to measure energy-related chemicals in the brain. The goal was to understand the disease better, not to test a treatment. About 50 adults with early-stage Hun…

This study looked at 16 people with severe facial paralysis to see how their brains change after reconstructive surgery. Using a brain scanning technique called magnetoencephalography (MEG), researchers measured brain activity during facial movements and while recognizing emotion…

This study looked at how blood flow and brain activity are linked in people with CADASIL, a rare genetic disease that causes small strokes. Researchers used MRI and EEG scans to measure these connections in 60 adults. The goal was to better understand the disease, not to test a n…

This study looked at how a small genetic difference (called TaqIB) affects the way 'good' HDL cholesterol works in the body. Researchers compared two groups of healthy men—those with one version of the gene versus another—to see how well their HDL helped remove cholesterol after …

This study looked at how the brain uses energy in people with early Huntington disease. Ten adults had an MRI scan to measure brain energy levels while resting and watching flashing lights. The goal was to understand brain metabolism, not to test a new treatment.

This study looked at the bacteria living in the small intestine and colon of 90 adults, including lean people, people with obesity, and people with both obesity and type 2 diabetes. Researchers collected samples during routine endoscopy or colonoscopy to compare the gut bacteria …

This study looked at how COVID-19 spread in France and how people's living conditions affected the outbreak. Over 134,000 people aged 15 and older from across France provided blood samples and answered questions about their health, home, work, and family life. The goal was to und…

This study collected umbilical cord blood from 44 newborns whose mothers carry the sickle cell trait. The goal was to study the cells in the lab to better understand the disease and develop ways to modify and preserve them. No treatment was given; this was purely for research pur…

This study looked at how the brain chemical dopamine behaves in people with idiopathic generalized epilepsy compared to healthy volunteers. Researchers measured yawning and blinking after giving a low dose of apomorphine, a drug that mimics dopamine. The goal was to understand br…

This study looked at how bariatric surgery affects taste receptors and taste perception in 20 obese patients. Researchers measured changes in taste before and 6 months after surgery. The goal was to understand why taste changes happen after weight loss surgery.

This study looked at how nerves in the spine work in people recently diagnosed with ALS compared to healthy volunteers. The goal was to find specific electrical signals that could help doctors understand the disease better and track its progress. 101 participants took part in tes…

This completed study in the Democratic Republic of the Congo followed 787 people who survived Ebola and their close contacts. Researchers tracked their health over time, looking for lingering virus, immune responses, and other infections. The goal was to better understand the lon…

This completed study examined air quality inside airplane cabins during smoke or fume events and whether these events affect the health of flight crew members. Researchers tested 357 crew members with cognitive tests, physical exams, and questionnaires. The goal was to detect any…

This completed study looked at how people with autism spectrum disorder pay attention to emotional cues and changes in their environment, compared to healthy individuals. Researchers used brain imaging (fMRI, DTI) and EEG to measure brain activity in 120 children and adults. The …

This study looked at how people with cervical or myoclonus dystonia perceive their own actions, known as the 'sense of agency.' Researchers used computer tasks and brain scans to measure how accurately participants felt in control of their movements. The goal was to link these fe…

This completed study observed nearly 27,000 pregnant women in French Caribbean departments during the 2016 Zika epidemic. Researchers tracked Zika infections and their impact on pregnancy, including rates of microcephaly and other fetal abnormalities. The goal was to better under…

This completed study looked at the genetic makeup of liver cancer in 808 patients. Researchers analyzed tumor samples to identify key genetic changes and patterns. The goal was to better understand the disease and find ways to classify tumors more precisely, which could eventuall…

This study tested whether healthy volunteers with minimal training could collect their own capillary blood using a finger prick during brief periods of weightlessness on parabolic flights. The goal was to see if the blood samples were good enough to measure caffeine levels after …

This study looked at how amyotrophic lateral sclerosis (ALS) affects the brain's ability to process touch and other sensations, even when patients don't notice problems. Researchers used brain imaging and electrical recordings to compare 52 people with ALS and healthy volunteers.…

This study aimed to create a better way to measure apathy—a lack of motivation and goal-directed behavior—in people with brain diseases like frontotemporal dementia and depression. Researchers used video recordings and body sensors to track behaviors in a real-life setting. 66 he…

This study looked at how the brain's wiring relates to impulsive behavior in people with Tourette syndrome. Researchers used MRI scans to compare brain activity and connections in 80 patients (some treated, some not) and 40 healthy volunteers. The goal was to find the brain areas…

This study looked at the brain's lymphatic system in 40 women with idiopathic intracranial hypertension (IIH), a condition causing severe headaches and vision loss. Researchers used a special MRI technique to compare lymphatic vessels in patients and healthy controls. The goal wa…

This study looked at adults who received low-dose radiation to the brain as children for a non-cancerous skin growth. The goal was to see if this radiation caused any long-term problems with memory, thinking, or other brain functions. Researchers tested 119 participants and compa…

This study looked at fat tissue from the belly and thigh in 20 healthy women to see if the cells are different. The goal was to understand why belly fat is linked to health problems while thigh fat may be protective. No treatment was given — the study simply observed and compared…

This study followed survivors of the 2015 Paris terrorist attacks for up to 6 years, using brain scans to see how trauma affects the brain's ability to control unwanted memories. Researchers compared 216 survivors with people who were not exposed to the attacks. The goal was to u…

This study followed 38 adults who survived severe breathing failure from the 2009 H1N1 flu. Researchers compared those who needed a machine to oxygenate their blood (ECMO) with those who did not. They measured lung function, quality of life, and mental health at least 9 months af…

This study followed over 3,400 children born very early (before 35 weeks) in France to learn about their health and development. Researchers checked for movement, thinking, and behavior problems when the children were 5 and a half years old. The goal is to better understand the l…

This study looked at how many people in homeless shelters in Paris had COVID-19 antibodies after the first wave. Researchers tested 179 residents and staff from three shelters to measure past infections and deaths. The goal was to understand the virus's impact on a vulnerable pop…

This study looked at immune cells from 4 healthy people shortly after they got a smallpox vaccine. Researchers wanted to see if these cells already show signs of long-term memory. The goal was to understand how the body builds lasting protection after vaccination.

This study followed 919 pregnant women in Paris to see how often they caught H1N1 flu during the 2009 pandemic and what happened to their pregnancies. Researchers also checked if the flu vaccine was safe. The goal was to better understand the risks of flu during pregnancy.

This study looked at how people with ALS start walking and keep their balance. Researchers compared patients with and without balance problems, plus healthy volunteers, using walking tests and brain scans. The goal was to understand the brain changes behind movement difficulties,…

This study looked at how the immune system responds in people with colon cancer. Researchers collected blood and tumor tissue samples from 100 patients and followed them for up to 5 years. The goal was to understand immune cell activity, not to test a new treatment.

This study looked at how 10 different drugs are broken down in the body. Ten healthy volunteers took the drugs, and researchers measured levels in the blood to create a personal metabolic profile. The goal was to learn more about drug processing, not to treat any disease.

This study aimed to find genetic markers that could predict which patients will develop vasospasm—a dangerous narrowing of brain arteries—after a bleeding brain aneurysm. Researchers collected blood samples daily from 89 patients for 12 days to analyze their DNA and RNA. The goal…

This study took small tissue samples from 16 people with or without inflammatory bowel disease during routine colonoscopies. Researchers grew these samples into mini-organs called organoids in the lab. They then tested how radiation and potential treatments affect these organoids…

This study tested whether methylphenidate (a drug used for ADHD) changes how healthy adults make decisions, put in effort, and learn from rewards. 35 participants completed tasks while on the drug or a placebo. The goal was to understand motivation, not to treat any condition.

This pilot study tested whether a new MRI technique called GRICS can take clear pictures of the heart while patients breathe normally. Thirty adults with heart disease (ischemic or dilated cardiomyopathy) had both standard breath-hold and free-breathing scans. The goal was to see…

This study used a technique called transcranial magnetic stimulation (TMS) to temporarily quiet specific brain areas in 17 healthy adults. The goal was to see how these areas affect the reflex that keeps your eyes steady when you move your head. The research helps us understand w…

This study looked at Netherton syndrome, a rare genetic skin condition, to better understand how it affects the body and immune system. Researchers studied 18 people with the disease, measuring immune markers in the blood and tracking skin changes. The goal was to find new target…

This study looked at whether people who have been cured of Cushing's disease for at least a year still have memory problems. Researchers used a special virtual reality test to check memory, along with standard tests. The goal was to better understand these lasting effects and imp…

This study compared the sense of smell in 240 people with and without bipolar disorder. Participants took tests measuring their ability to detect, tell apart, and identify odors. The goal was to see if smell performance relates to brain imaging data, helping researchers better un…

This study tested a new ultrasound technique to detect blood flow inside solid bone, which current methods cannot do. Nineteen healthy adults had their forearm and shin scanned while blood flow was changed using a blood pressure cuff or by changing position. The goal was to see i…

This study used special MRI techniques to see how brain cells change after a stroke. Researchers scanned 24 stroke patients and 24 healthy volunteers to measure water and chemical movement in brain tissue. The goal was to learn more about what happens inside brain cells during a …

This early study tested whether a painless, non-invasive brain stimulation technique called tDCS could change the brain's control over the diaphragm, the main breathing muscle. Twelve healthy men received three types of stimulation (positive, negative, and fake) while researchers…

This study looked at whether certain proteins, called beta-arrestins, can help predict how well people with major depression will respond to the antidepressant venlafaxine. Researchers measured these proteins in 67 patients before and during treatment, and compared them to health…

This study looked at 99 adults with high heart disease risk to understand how a protein called CETP relates to plaque buildup in arteries. Researchers measured CETP activity in the blood and used imaging to check artery thickness and calcium. The goal was to see if CETP could ser…

This study looked at how Parkinson's disease changes the way people perceive time. Researchers measured eye movements in 40 participants (Parkinson's patients and healthy volunteers) to understand the role of dopamine in timing. Patients were tested both on and off their medicati…

This study looked at how well seasonal and H1N1 pandemic flu vaccines triggered immune responses in 147 healthy healthcare workers. Researchers wanted to see if age and past flu shots affected the body's antibody and cell-based defenses. The goal was to better understand vaccine …

This study looked at 30 people in the ICU with severe H1N1 flu who needed a breathing machine. Researchers collected fluid from the lungs to study the virus and the body's immune response. The goal was to learn more about what causes severe illness, not to test a new treatment.

This study followed more than 3,000 adults with moderate to advanced chronic kidney disease (CKD) for up to 5 years. Researchers collected health data and blood/urine samples to identify factors that lead to kidney failure, heart problems, and other complications. The goal was to…

This study looked at whether a special video game could help improve walking and balance in 10 people with Parkinson's disease who had already had brain surgery. The goal was to see if the game was easy and enjoyable to use. Researchers measured how well participants could walk a…

This study looked at 94 adults to see if following French nutrition guidelines affects blood vessel health. Participants were split into two groups based on their diet quality, and researchers measured artery stiffness and blood flow before and after a standard breakfast. The goa…

This study looked at how two brain regions—the cerebellum and the supplementary motor area—help us keep our balance when we start walking. Twenty healthy adults had their balance measured before and after temporarily 'turning off' each brain area with magnetic pulses. The goal wa…

This study looked at how the prefrontal cortex helps us think in analogies and categories. Researchers tested healthy volunteers and patients with frontotemporal dementia or progressive supranuclear palsy using tasks that measure reaction time and accuracy. They also used brain s…

This study looked at how healthy young adults (ages 18-35) can intentionally forget negative memories. Using brain wave recordings (EEG) and tasks involving images, researchers aimed to understand the brain's natural ability to suppress unwanted thoughts. The goal is to learn mor…

This study looked at how shared cultural memories (like those about World War II) affect the way individuals remember things. Twenty-six healthy adults had their brains scanned with fMRI while looking at pictures and recalling details. The goal was to understand how collective kn…

This study looked at over 1,000 mothers and daughters to understand how bone structure and strength are passed down through families. Researchers compared bone scans and fracture history between mothers who had broken a bone easily and those who hadn't. The goal was to learn more…

This study looked at why some people with Alzheimer's or frontotemporal dementia lose awareness of their own condition (anosognosia). Researchers used brain scans and EEG to measure how the brain reacts to mistakes and emotional signals in 77 participants. The goal was to find br…

This study tested a new, non-invasive way to monitor chemotherapy effects in 16 people with advanced colorectal cancer. Researchers measured special substances in urine samples taken before and after treatment to see if they could track cancer activity without blood draws or scan…

This study looked at gene activity in the uterine lining during menstruation to understand why humans have periods while some other primates do not. Researchers collected menstrual fluid from 21 healthy women using a silicone cup, a non-invasive method. The goal was to learn more…

This study looked at how COVID-19 spread among patients and healthcare workers in four hospitals in Bamako, Mali. Researchers used molecular tests to find active infections and blood tests to check for past infections and immunity. The goal was to understand infection rates, incl…

This study looked at how two brain regions—the cerebellum and striatum—communicate in people with dystonia caused by ADCY5 or PRRT2 gene mutations. Researchers used MRI scans and mild brain stimulation to compare brain activity among patients and healthy volunteers. The goal was …

This study looked at how people with dystonia, essential tremor, or Parkinson's disease adapt their eye movements compared to healthy volunteers. Researchers used a special eye-tracking device to measure changes before and after a task. The goal was to learn more about how the ce…

This study measured COVID-19 antibodies in over 2,800 primary care health workers (like doctors, pharmacists, and dentists) and their household members in France. The goal was to understand how many had been exposed to the virus and how their immune systems responded. Results hel…

This completed study looked at how the cerebellum, a part of the brain that helps coordinate movement, influences brain plasticity in people with dystonia (a movement disorder causing muscle spasms) and in healthy volunteers. Researchers used mild brain stimulation to temporarily…

This study looked at how people with alcohol use disorder (AUD) organize words and ideas in their memory compared to healthy individuals. Researchers tested 41 participants using word association tasks and brain function tests. The goal was to see if changes in these mental netwo…

This pilot study tested whether it is possible to quickly analyze the genetic makeup of tumors from 24 adults with advanced colorectal cancer or soft tissue sarcoma. The main goal was to see how long it takes to get a complete genetic report back to the doctor after receiving a s…

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS). The goal was to see if these changes happen early in the disease and differ between MS types. Participants had one eye exam at the …

This study looked at how skin cells from 30 people with recessive dystrophic epidermolysis bullosa (RDEB) grow and repair wounds. RDEB is a rare genetic condition that causes fragile skin and painful blisters. Researchers took small skin samples to study the cells in a lab, aimin…

This study examined the DNA of over 2,300 adults who experienced sudden cardiac arrest outside the hospital. Researchers looked for specific genetic variations that might increase the risk of sudden death. The goal is to better identify people at high risk so that future preventi…

This study followed 364 adults with severe stroke who needed a breathing machine in the ICU. Researchers measured their recovery and disability levels at 3 months and 1 year after ICU admission. The goal was to better understand what happens to these patients over time, not to te…

This study looked at whether advanced genetic testing (called NGS) can be done quickly enough to help guide treatment choices for people with advanced soft-tissue sarcoma. About 600 adults with this rare cancer took part. The goal was to see if using genetic information to pick t…

This study collected blood samples from over 2,200 people with Alzheimer's or other dementias, plus healthy volunteers, to search for genes linked to these diseases. Researchers aimed to identify new genetic causes and better understand how genes affect disease risk and progressi…

This study tested a new, highly sensitive ultrasound technique to map brain activity during surgery. Researchers compared it to standard methods in 23 adults with brain tumors or lesions. The goal was to see if this low-cost, real-time imaging could help surgeons identify importa…

This study tested a decision aid for women with a less active ectopic pregnancy (a pregnancy outside the womb that is not growing quickly). 109 women and their doctors used the tool and then answered questions about how helpful and clear it was. The goal was to see if the tool he…