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ADHD Drug's secret power: boosting motivation in healthy brains?

NCT ID NCT03190681

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether methylphenidate (a drug used for ADHD) changes how healthy adults make decisions, put in effort, and learn from rewards. 35 participants completed tasks while on the drug or a placebo. The goal was to understand motivation, not to treat any condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

35 people

The number who actually took part.

Started

Jul 2017

Finished

Nov 2017

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * weight\>= 50kg and \<=90kg * free and informed consent * social security affiliation * no chronic illness * no previous participation to a protocol wth similar tasks * no special legal status (guardianship,trusteeship) * no personnal or familial neurologic or psychiatric background * no contraceptive device for a reproductive woman Exclusion Criteria: * inability to squeeze a handgrip * smoking * psychoactive substance consumption less than 3 weeks ago * pregnant or breastfeeding woman * hypersensitivity to methylphenidate * hyperthyroidism * cardiovascular or cerebrovascular disease * respiratory, hepatic or renal failure * glaucoma * pheochromocytoma * gluten intolerance or hypersensitivity * galactosemia, glucose malabsorption syndrome, lactase deficit * countraindicated meds (IMAO, IMAO-A, orhtosympathomimetics, alcaloids, linezolin, enzymatic inducers, psycho-active drugs)

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Conditions

The condition(s) this trial relates to.

Impulsive Behavior Lethargy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APATHY Impulsive behavior Motivation

Contacts and locations

Locations

  • Centre d'investigation clinique, Institut du Cerveau et de la Moelle

    Paris, 75013, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.