APATHY

This study is testing whether a gentle, non-invasive electrical stimulation delivered to the ear can improve apathy (loss of motivation) and other non-motor symptoms in people with Parkinson's disease. Researchers will compare the real stimulation to a sham (fake) treatment in 60…

This study is testing whether a combination of a stimulant medication (methylphenidate) and a non-invasive brain stimulation technique can help reduce apathy in people with Alzheimer's disease or mixed dementia. The treatment aims to improve motivation and engagement. Researchers…

This study is testing whether a daily digital app that helps people reminisce about personal memories can improve symptoms like low mood, lack of motivation, and poor sleep in older adults with mild cognitive impairment or early-stage dementia. Participants will use the app for a…

This study is testing whether a 4-week digital brain training program can help reduce apathy and improve brain function in older adults with depression. Researchers will enroll 84 participants aged 60+ who have both depression and significant apathy. The program aims to strengthe…

This study is testing whether a virtual 'Life Story Club' can help reduce feelings of loneliness and apathy in older adults living independently. Researchers will enroll 50 participants aged 60+ to attend weekly online group sessions for 12 weeks, where they share personal storie…

This study is testing whether a non-invasive brain stimulation technique called rTMS can safely help people who have lost motivation and interest in life after a stroke. Researchers will deliver multiple short stimulation sessions over two weeks to a specific brain area linked to…

This study aims to find out if a new oral medication called IRL757 is safe and tolerable for people with Parkinson's disease who also experience apathy—a lack of interest or motivation. About 75 participants will take either the study drug or a placebo (inactive pill) daily for 1…

This study is observing 100 adults with treatment-resistant depression who are already prescribed esketamine nasal spray in real-world settings. Researchers are tracking how well it works, who responds best, and how it affects people's daily lives and functioning. The goal is to …

This study aims to understand how listening to personally chosen music might help reduce apathy—a common lack of motivation and emotion—in people with Parkinson's disease. Researchers will enroll 50 participants to use an 8-week music listening program while measuring changes in …