APATHY

This study tests whether a 4-week digital brain-training program can reduce apathy (loss of interest or motivation) in adults aged 60 and older with major depression. Participants will use a customized computer program designed to improve brain connections linked to motivation an…

This study tests an experimental drug called IRL757 in 75 people with Parkinson's disease who also have apathy (loss of interest or motivation). The main goal is to check if the drug is safe and tolerable over 12 weeks. Researchers will also see if it helps improve apathy symptom…

This study tests a non-invasive device that gently stimulates a nerve in the ear, timed with breathing, to see if it can improve apathy (lack of motivation) in people with Parkinson's disease. Sixty participants will receive either the real stimulation or a sham (fake) version fo…

This study explores whether listening to personalized music can help reduce apathy (lack of motivation and emotion) in people with Parkinson's disease. Researchers will use brain scans to understand how music affects the brain's reward and motivation centers. Fifty participants w…

This study tests a fast form of brain stimulation (rTMS) to help people who feel apathetic after a stroke. Apathy means losing motivation and interest in daily life. The treatment targets a brain area linked to motivation and is given over a short period. The goal is to see if it…

This study tests whether using a digital app that shares personalized memories can improve symptoms like apathy and depression in older adults with mild neurocognitive disorders. Eighty participants over age 60 will use the app for 10-15 minutes daily over 25 days. Researchers wi…

This study tests whether using robots at home can reduce apathy—a lack of motivation or interest—in people with mild cognitive impairment or dementia. About 75 adults over 40 with apathy will be randomly assigned to interact with a telepresence robot, a social robot, or receive s…

This study tests if combining a medication (methylphenidate) with a type of non-invasive brain stimulation can reduce apathy in people with Alzheimer's disease or mixed dementia. Apathy, or lack of motivation, is a common and troubling symptom. The study will involve 12 participa…

This study tests whether a virtual group where older adults share their life stories can reduce loneliness and apathy. Researchers will enroll 50 people aged 60 and older who can speak English or Spanish and have internet access. Participants join online reminiscence sessions, an…

This study watches 100 adults with treatment-resistant depression who are taking esketamine nasal spray as part of their normal care. Researchers want to see how well it works, who responds best, and how it affects daily life, work, and mood. They will also look at genetic and br…