APATHY

This study tested a 12-week diet and exercise program in 40 older adults with insulin resistance and apathy (a motivation disorder). Participants received all meals and supervised exercise. The goal was to see if the program improves insulin sensitivity and reduces apathy, and wh…

This study tested whether a non-invasive magnetic brain stimulation technique (TMS) can reduce apathy—a severe lack of motivation—in older Veterans with mild memory problems. About 100 participants received either real or sham stimulation over 20 sessions. The goal was to see if …

This study looked at how methylphenidate (a drug used for ADHD) changes motivation in 35 healthy adults. Participants completed tasks measuring decision-making, effort, and learning. The goal was to understand the drug's effect on motivation, not to treat any condition.

This pilot study tested whether wearable sensors can accurately measure apathy in people with frontotemporal dementia compared to healthy volunteers. Researchers used video recordings and motion sensors to track behaviors like lying, sitting, and walking in real-life settings. Th…

This early-stage study tested a single dose of the drug IRL757 in 12 healthy volunteers aged 65 to 89. The goal was to see how the drug moves through the body and whether it is safe. No treatment was given for any disease, so this study does not offer a cure or symptom relief.

This study looked at how apathy (lack of interest or motivation) influences different types of fatigue in older adults with mild neurocognitive disorders. Researchers compared 30 apathetic and 30 non-apathetic participants aged 65-85. Participants wore activity trackers for a wee…