Scientists probe Dopamine's role in epilepsy with yawn and blink test
NCT ID NCT01432821
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how the brain chemical dopamine behaves in people with idiopathic generalized epilepsy compared to healthy volunteers. Researchers measured yawning and blinking after giving a low dose of apomorphine, a drug that mimics dopamine. The goal was to understand brain differences, not to treat the condition. 31 people took part.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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31 people
The number who actually took part.
- Start date
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Sep 2011
- Finished
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Dec 2014
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: For patients: * Men and women aged between 18 and 40 * Person affiliated to social security or beneficiary of such a regime * idiopathic generalized epilepsy treated with lamotrigine, an association of lamotrigine, topiramate, levetiracetam, lamotrigine or levetiracetam alone (group patients) for at least 14 days without changing doses The idiopathic generalized epilepsy is defined by generalized seizures: generalized tonic-clonic seizures, absences or myoclonic seizures, excluding any other type of seizure, and electroencephalographic appearance following: presence of interictal EEG discharge generalized to type of spikes, spike-wave or wave polyspikes generalized, sporadic or rhythmic\> or = 3 Hz background activity is normal. For healthy volunteers: * Men and women aged between 18 and 40 * Person affiliated to social security or beneficiary of such a regime Exclusion Criteria: * Topic wrongly included * Deflecting protocol that can skew the primary endpoint * Primary endpoint missing * If the investigator considers the health of the subject is incompatible with the continuation of the study. Criteria for non-inclusion * For patients: * The presence of interictal focal discharges on EEG previous * The emergence of partial seizures * Restless Leg Syndrome * All non-antiepileptic treatment may affect levels of dopamine * Current use of illicit drugs. * A person deprived of liberty by judicial or administrative person being a measure of legal protection. * Pregnant, parturient, lactating mother. * For women, lack of effective contraception * For healthy volunteers: * Any medical treatment associated * Current use of illicit drugs * Pregnant, parturient, lactating mother * For women, lack of effective contraception * A person deprived of liberty by judicial or administrative person being a measure of legal protection.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CIC Department - University Hospital of Grenoble
La Tronche, Isere, 38700, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.