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Talking yourself out of cravings: brain scans reveal how Self-Talk may rewire food addiction

NCT ID NCT05101863

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether motivational interviewing—a therapy that helps people find their own reasons to change—can shift brain activity and food choices in people with food addiction. 56 participants, including those with and without obesity, underwent brain scans while making dietary decisions after talking about change. The goal was to see if self-generated 'change talk' alters the brain's reward response to food.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
motivational interviewing
What this could lead to
If successful, this could help improve talking therapies for food addiction by showing how self-generated reasons for change affect the brain.
What could go wrong
This is a small, completed study (56 people) that looks at brain scans, not a treatment trial. Results may not apply to everyone or lead to a direct therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

56 people

The number who actually took part.

Started

Sep 2022

Finished

Oct 2024

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

3 groups: * obese, food addicted participants * obese, NON-food addicted participants * normal-weight, NON-food addicted control participants

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Group: Normal-weight, NON-food addicted control participants * no food addiction, no eating disorder, no nutrition troubles, no weight management troubles * BMI: between 18.5 kg/m2 and 25 kg/m2 * age 18 to 70 years * right-handed * male / female * able to understand instructions and perform tasks * no psychiatric or neurological disorders * no drug abuse * written and informed consent Group: obese, food addicted * BMI \>= 30 kg/m2 * YFAS score \> = 2 * no other addictions * age 18 to 70 years * right-handed * male / female * able to understand instructions and perform tasks * no recently diagnosed psychiatric or neurological disorders * no drug abuse * written and informed consent Group: obese, NON-food addicted * age 18 to 70 years * BMI \>= 30 kg/m2 * YFAS score \< =1 * no other addictions * right-handed * male / female * able to understand instructions and perform tasks * no recently diagnosed psychiatric or neurological disorders * no drug abuse * written and informed consent Exclusion Criteria: * bad MRI quality * drop out

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Conditions

The condition(s) this trial relates to.

Food Addiction Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Food addiction, obesity, fmri, decision-making, motivational interviewing

Contacts and locations

Locations

  • Liane Schmidt

    Paris, Île-de-France Region, 75013, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.