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Brain scans reveal how OCD therapy rewires the mind

NCT ID NCT01331876

First seen Oct 31, 2025 · Last updated Jun 22, 2026 · Updated 31 times

Summary

This study looked at how two different types of cognitive behavioral therapy (CBT) affect brain activity in people with obsessive compulsive disorder (OCD). 35 adults with checking symptoms and moderate-to-severe OCD received 15 therapy sessions. Researchers used brain scans before, during, and after treatment to see which therapy led to greater changes in brain regions linked to OCD.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Pitié-Salpêtrière hospital

    Paris, 75013, France

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

cognitive behavioral therapy (CBT)

What this could lead to

If successful, this could help tailor CBT approaches to better treat OCD by understanding which therapy changes brain activity most.

What could go wrong

This is a small, early-stage study focused on brain imaging, not on proving a new treatment works. Results may not lead to direct clinical changes.

Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.