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Brain scans reveal how OCD therapy rewires the mind

NCT ID NCT01331876

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how two different types of cognitive behavioral therapy (CBT) affect brain activity in people with obsessive-compulsive disorder (OCD). Thirty-five adults with OCD completed 15 therapy sessions and had brain scans before, during, and after treatment. The goal was to see if the therapies cause different changes in brain regions linked to OCD, such as the prefrontal cortex and basal ganglia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cognitive behavioral therapy
What this could lead to
If successful, this could help tailor OCD therapies based on brain activity changes, improving treatment effectiveness.
What could go wrong
This is a small, early-stage study (35 people) focused on brain imaging, not on proving which therapy works best. Results may not apply to all OCD patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

35 people

The number who actually took part.

Start date

Oct 2009

Finished

Jul 2012

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 65; * Following Obsessive Compulsive Disorder criteria according to DSM IV(300.3 ;MINI 5.0.0); * OCD severity range from 20 to 30 on the Y-Brown obsessive compulsive scale; * Having checking symptoms; * Understanding and accepting the study; * Giving his written informed consent to the study. Exclusion Criteria: * Claustrophobia; * Cerebral abnormality; * Chronic absenteism to CBT (more than 5 missed sessions during the whole therapy). In case of exclusion of the study either decided by the patient himself or by the investigator, a debriefing is proposed by a psychologist.

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obsessive compulsive disorder

Contacts and locations

Locations

  • Pitié-Salpêtrière hospital

    Paris, 75013, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.