New device aims to loosen stiff legs in stroke survivors

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Stroke, with cortical and/or subcortical lesions, of at least 6-months duration at study inclusion * Spasticity in the lower extremity plantarflexors (gastrocnemius, soleus muscles) due to stroke with a baseline score of 1-4 as assessed by the Tardieu scale * Minimum 1-month duration of spasticity as confirmed by medical history * Modified Rankin score \< 4 * Cognitive functions sufficient to understand the experiments and follow instructions and ability to provide informed consent in accordance with ICH and GCP * Affiliated with the French social security scheme, universal medical coverages (CMU), or an equivalent scheme. Exclusion Criteria: * Enrollment in another biomedical research study at the time of the MyoRegulator study. * Fixed contractures or profound muscle atrophy in the spastic limb * Ongoing use of digitalis, morphine, intrathecal pump * Plantar orthosis or history of orthopedic surgery that can interfere with gait analysis * Botulinum toxin treatment within 12 weeks of study enrollment * Prior phenol or alcohol injections within 6 months of study enrollment * Change in the antispastic treatment (baclofen, clonidine, benzodiazepine, dantrolene, gabapentine, tizanidin) in the 2 months prior to visit 1. * Allergy to latex * Presence of potential tsDCS risk factors: * Damaged skin at the stimulation sites (i.e., skin with ingrown hairs, acne, razor nicks, wounds that have not healed, recent scar tissue, broken skin, cancerous lesions, etc.) * Lack of sensory perception at the stimulation sites * Presence of an electrically, magnetically or mechanically activated implant (including cardiac pacemaker, epidural stimulation electrodes, etc.), an intravascular clip or any other electrically sensitive support system * Metal in or on the body in the direct path of the stimulation current (jewelry must be removed during stimulation) * Past history of seizures or unexplained spells of loss of consciousness during the previous 36 months * Prior trans-spinal direct current stimulation for any reason or prior trans-cranial direct current stimulation in the past 12 months * Any medical condition that would prevent the subject from being able to participate in the clinical outcome measures * Pregnancy in women (as determined by a urine pregnancy test in pre-menopausal women), or lactating women or women planning pregnancy during the course of the study * Patient under guardianship or curatorship, or under judicial supervision