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Brain scans reveal how facial paralysis surgery rewires emotion processing

NCT ID NCT06809127

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 16 people with severe facial paralysis to see how their brains change after reconstructive surgery. Using a brain scanning technique called magnetoencephalography (MEG), researchers measured brain activity during facial movements and while recognizing emotions like happiness and sadness. The goal was to understand how the brain adapts and whether emotion recognition improves after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Jun 2017

Finished

Feb 2023

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * No history of psychiatric illness * Severe facial palsy (V or VI grade on House and Brackman scale) * No evolutive neurologic pathology beside the lesion of the VIIth nerve * Signature of informed consent * Being a member of, or beneficiary of, a social security scheme Exclusion Criteria: * Evolutive neurological disease outside the lesion of the VIIth nerve * General pathology leading to neuropathy * Person unable to express his/her consent * Adult under a legal protection measure * Adult deprived of liberty by judicial or administrative decision. * Adult participating in another research protocol involving the human person or subjected to a period of exclusion from another research * Claustrophobia * Implants or metallic objects (including eyeglasses) that are susceptible to pertrubate the MEG signal * Treatment with known action on the central nervous system (Excessive recreational use of psychotropic drugs, ongoing benzodiazepine therapy) * For the patients who will undergo a complementary structural MRI for MEG source localisation, additional exclusion criteria are the contraindications to MRI (including: pacemaker or neurosensitive stimulator or implanted defibrillator, anevrism or vascular malformation of the brain, cochlear implants, ferromagnetic objects or prosthesis in the eyes or brain, mechanical heart valve prosthesis, permanent eye makeup; pregnant or nursing women)

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Conditions

The condition(s) this trial relates to.

Bell's palsy facial paralysis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Facial palsy Surgery

Contacts and locations

Locations

  • Frederic TANKERE

    Paris, 75651, France

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Other studies related to the condition(s) this trial covers.