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Zapping the brain to stop the shakes: small trial shows promise

NCT ID NCT02052271

Symptom relief Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a mild electrical current applied to the back of the head (cerebellum) can reduce shaking in people with essential tremor. Sixteen adults whose usual treatments weren't working well took part. Researchers measured tremor changes using rating scales and motion sensors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Jun 2014

Finished

Mar 2018

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years and ≤ 65 years * Important essential tremor (bilateral postural and/or action tremor since more than one year) * Normal physical and neurological examination, except for essential tremor * Insufficient efficiency of usual essential tremor's treatment * No treatment altering the cortical excitability * Agreement to use a medically acceptable method of contraception throughout the study for female of childbearing potential * mini-mental status score \>24 Exclusion Criteria: * Age \< 18 years and \> 65 years * Current neurological or psychiatric illness other than essential tremor * Individual who is on medication which is known to lower seizure threshold * Previous history of seizure, loss of conciousness or current active epilepsy * Contraindication for MRI or TMS study * Intake of antiepileptic medications for essential tremor (barbiturates, gabapentine, topiramate, clonazepam), within the 7 days preceeding the first visit * alcohol intake within the 24 hours preceeding the first visit * Pregnancy, breast feeding women and women who are of childbearing age and not practicing adequate birth control * Individual who have MMS ≤ 24/30 or patients legally protected or inability to provide an informed consent * Simultaneous participation in another clinical trial * Patients who are not enrolled at social security

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Conditions

The condition(s) this trial relates to.

essential tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Essential tremor

Contacts and locations

Locations

  • Institut du Cerveau et de la Moelle, Hôpital Pitié-Salpétrière

    Paris, 75651, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.