Massive french study reveals flu Vaccine's Real-World power in hospitals
NCT ID NCT02027233
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how well the seasonal flu vaccine works in adults who are hospitalized with severe flu-like illness. Researchers compared vaccinated and unvaccinated patients across a network of French hospitals to see if the vaccine reduced confirmed flu cases. The goal is to better understand vaccine effectiveness and the burden of other respiratory viruses like RSV and COVID-19 in hospitalized adults.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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6,173 people
The number who actually took part.
- Started
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Jan 2014
- Finished
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Dec 2022
- Lead sponsor
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A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 year * Affiliated with social security health insurance * Written informed consent * Patients hospitalized for at least 24 hours for one of the reasons indicated in Table 1 of protocol * Presence of Influenza-like syndrome before the hospitalization (even if symptoms are not present at the time of inclusion), or less than 48 hours after the hospitalization * Rapid completion of nasopharyngeal sample after hospitalization without exceeding 7 days after the onset of Influenza-like syndrome Exclusion Criteria: * Realization of nasopharyngeal sampling more than 7 days after the onset of symptoms * Contraindication for influenza vaccine (Hypersensitivity to the active substances, to any of the excipients and to trace eg eggs, including ovalbumin, chicken protein) * Patients institutionalized without regular community interaction * Previously tested positive for any influenza virus in the current season (RT-PCR, multiplex RT-PCR) * Patient under curatorship or under guardianship whose sample was obtained as part of their medical care but not complying with the conditions of Article L1121-8 of the Code de la Santé Publique. * Patient under curatorship or under guardianship whose sample was not obtained as part of their medical care.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Institut National de la Santé Et de la Recherche Médicale
Paris, 75654, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.