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Scientists probe Brain's wiring to boost depression treatment

NCT ID NCT07071259

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study aims to better understand how the brain's prefrontal cortex is organized, specifically the part linked to mood and thinking. Researchers will use advanced MRI and TMS-EEG in 34 healthy adults to map connections between brain regions. The goal is to improve targeting of a therapy called rTMS, which is used for severe depression but currently works for only 20-40% of patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Transcranial magnetic stimulation (TMS) and high-field MRI
What this could lead to
If successful, this could lead to more precise targeting of brain areas for rTMS therapy, potentially improving depression treatment outcomes.
What could go wrong
This is a small, early-stage study in healthy volunteers, not patients. The findings may not translate directly to clinical practice, and the approach is still experimental.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * People aged 18 to 35 * People affiliated with a social security scheme or beneficiary of such a scheme * People who have signed the informed consent * Right-handed people * People with a body mass index between 18 and 26 * People able to abstain from alcohol for 24 hours prior to the experiment * People able to remain perfectly still for 15 minutes straight, and able to have reduced mobility for 3 hours * People able to of not using narcotics (marijuana, cocaine, ecstasy, MDMA, ketamine, etc.) during the 15 days preceeding the experiment. * Conducting a pregnancy test before inclusion for women of childbearing age and when the research is conducted over a long period, at a frequency adapted to the gaze of the research acts * Effective contraception for women of childbearing potential Exclusion Criteria: * Pregnant, parturient, or breastfeeding * Protected adults * Minors * People staying in a healthcare or social institution * People in an emergency situation * People deprived of their liberty * People with the usual contraindications to MRI * Ferromagnetic surgical clips, ocular implants, metallic foreign bodies intraocularly or in the nervous system, implants or metallic objects susceptible to concentrate the radio frequency field, cochlear implants, brain stimulator or cardiac pacemaker, presence of a craniotomy scar, agitation * Claustrophobia * Large, black tattoo close to the orofacial area * People not wishing to be informed of abnormalities discovered at the MRI * People with a history of epilepsy or suffering from epilepsy * Individuals whose parents, children, siblings, or parents have a history of epilepsy * People with known neurological and/or psychiatric disorders with past and/or current medical treatment, or drug addiction * Staff with a hierarchical link to the investigators

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Hôpital la Timone

    RECRUITING

    Marseille, 13005, France

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