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Vitamin c mystery: scientists track how water affects absorption

NCT ID NCT00001309

Knowledge-focused Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 14 times

Summary

This completed study looked at how vitamin C moves through the body in healthy adults. Researchers placed 23 volunteers on a low-vitamin C diet, then gave them increasing doses of vitamin C by mouth and IV. They measured vitamin C levels in blood and urine to see how water intake affects those levels. The goal was to better understand vitamin C's pharmacokinetics, not to treat any disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin C (ascorbic acid)
What this could lead to
If successful, this study could improve understanding of how vitamin C is absorbed and used by the body, potentially guiding future dietary recommendations.
What could go wrong
This is a small, early-phase study in healthy volunteers, not designed to test any treatment. Results may not apply to people with medical conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

23 people

The number who actually took part.

Started

Jan 1997

Finished

Mar 2019

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: * 10 Males - ages 18 - 35 yrs * 10 Females - ages 18 - 35 yrs No more than 4 subjects during any period will remain as inpatients on the endocrine/metabolic ward. These subjects will be normal volunteers selected from colleges/universities who will: 1. Spend within a fall or spring semester (approximately 20-26 weeks) as an inpatient resident on the endocrine-metabolic ward at NIH. 2. Be willing to adhere to an ascorbate restricted diet for the duration of the time spent in the study as an inpatient at NlH. 3. Have veins adequate for venipunctures and be willing to undergo venipunctures approximately two to three times per week. 4. Refrain from ingestion of any medication and cigarette smoking and ethanol. 5. Be able to give informed consent. EXCLUSION CRITERIA: 1. Subject non-compliance with restricted diet. 2. Pregnancy as determined by history, physical exam and urine b-HCG. 3. History of diabetes mellitus, bleeding disorders, kidney stones, glucose-6- phosphate dehydrogenase deficiency, family history of hemochromatosis/iron overload. 4. Platelet count \<150,000/ul blood; prothrombin time/partial thromboplastin time (PT/PTT) \> 1 second above normal upper limit. 5. Positive test for exposure to human immunodeficiency virus. 6. Positive tests for hepatitis B surface antigen, core antibody or surface antibody.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteers

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

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