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E-Cigarettes vs. cigarettes: which delivers nicotine faster?

NCT ID NCT02032212

Knowledge-focused Sponsor: Imperial Brands PLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looked at how quickly and how much nicotine gets into the blood from e-cigarettes, a nicotine inhalator, and regular cigarettes. Twelve healthy smokers took part, and researchers measured nicotine levels and withdrawal symptoms. The goal was to understand the nicotine delivery profile of e-cigarettes compared to other products.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nicotine
What this could lead to
If successful, this could help understand how e-cigarettes deliver nicotine compared to traditional cigarettes and inhalators.
What could go wrong
This was a very small, early study with only 12 participants, so results may not apply to all smokers or products. It measured nicotine levels, not health effects or quitting success.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Start date

Dec 2013

Finished

Dec 2015

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 65 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI of 18-35kg/m2 * Subjects must be established smokers * Subjects must have smoked five to 30 cigarettes per day for at least one year Exclusion Criteria: * Subjects who have used nicotine replacement therapy within 14 days of the screening * Subjects who have donated blood within 12 months preceding study * Subjects with relevant illness history * Subjects positive for hepatitis or HIV * Subjects with history of drug or alcohol abuse * Subjects with lung function test or vital signs considered unsuitable * Subjects who are trying to stop smoking

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteers

Contacts and locations

Locations

  • Simbec Research

    Merthyr Tydfil, Wales, CF48 4DR, United Kingdom

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