New combo vaccine targets deadly diarrhea in kids

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female adults, children, toddlers, and infants aged between 18-45 years, 2-5 years, 12-23 months, and 6-11 months, respectively at the time of vaccination. * Free of obvious health problems as determined by medical history and clinical examination before entering into the study. * Normal bowel habits. * Informed consent form signed. * Negative pregnancy tests before each vaccination for females of childbearing potential. Adult participants agree to use birth control steps or abstinence. Exclusion Criteria: * Nursing and breast-feeding women. * Presence of any known significant medical or psychiatric condition / systemic disorder. * History of congenital abdominal disorders, intussusception, abdominal surgery, any other congenital disorder, any neurologic disorders or seizures. * Clinically significant abnormalities in screening hematology, serum chemistry. * Known or suspected HIV, hepatitis infection. * Clinical evidence of active gastrointestinal illness or acute disease at the time of enrolment. * Prior receipt of any Shigella or ETEC vaccine, blood transfusion or blood products. * History of febrile illness within 48 hours prior to vaccination or fever at the time of immunization. * History of diarrhoea within 7 days and / or acute diarrhoea due to culture confirmed Shigella or ETEC infections within one month prior to vaccination. * Screening stool positive for any Shigella or ETEC strain by culture. * Participation in research involving another investigational product within 30 days before before planned date of first vaccination concurrent participation in another clinical trial. * Receipt of antimicrobial drugs for any reason within 7 days before vaccination. * Allergy to quinolone, sulfa, and penicillin classes of antibiotics * Any conditions which, in the opinion of the investigator, might jeopardize the safety of study participants or interfere with the evaluation of the study objectives.