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E-Cigarettes vs regular cigarettes: which delivers more nicotine?

NCT ID NCT05457634

Knowledge-focused Sponsor: Fontem US LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how much nicotine gets into the blood and how strong the urge to smoke is when using blu disposable e-cigarettes compared to regular cigarettes. Twenty adult smokers who smoke at least 10 cigarettes a day took part. They used both their usual cigarette and different flavored blu e-cigarettes in controlled sessions to measure nicotine levels and smoking behavior.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nicotine (from e-cigarettes and combustible cigarettes)
What this could lead to
If successful, this study could help regulators understand how e-cigarettes compare to regular cigarettes in terms of nicotine delivery and addiction potential.
What could go wrong
This is a small, completed study with only 20 healthy smokers, so results may not apply to all smokers or long-term use. It does not test health effects or quitting success.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Jul 2021

Finished

Aug 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects must be current smokers (≥10 per day) of combustible cigarettes for at least 6 continuous months before Visit 1 and may be occasional users of e-cigarettes * Subjects have urine cotinine \>200 ng/mL and exhaled carbon monoxide \> 10 ppm at Screening * Subject has a seated systolic blood pressure ≤160 mmHg, diastolic blood pressure ≤95 mmHg, and heart rate ≤100 bpm * Females of childbearing potential who are practicing a reliable method of contraception Exclusion Criteria: * Subjects who have used any nicotine or tobacco product other than e-cigarettes or combustible cigarettes in the 14 days prior to Visit 1 * Subjects who have an acute illness requiring treatment in the 4 weeks prior to Visit 1 * Subjects with clinically significant and relevant abnormalities of medical history. * Subjects who have used any prescription or over-the-counter smoking cessation treatments within 30 days prior to Visit 1 * Pregnant or breastfeeding female subjects

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy volunteers

Contacts and locations

Locations

  • LA Clinical Trials, LLC

    Burbank, California, 91505, United States

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