Blood protein clues may predict dangerous pregnancy problems
NCT ID NCT04205383
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant volunteers. The goal was to find early markers that could improve monitoring and treatment, but this was an observational study, not a treatment trial.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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115 people
The number who actually took part.
- Started
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Mar 2019
- Finished
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Nov 2019
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
pregnant patient with a complication of the placental vascular pathology type (pre-eclampsia, eclampsia, HELLP syndrome, retroplacental hematoma, fetal death in utero) or venous thromboembolic disease (deep vein thrombosis, pulmonary embolism). AND pregnant woman, without complications (normal pregnancy), absence of identified chronic pathology, absence of a history of neoplastic pathology, absence of a history of thromboembolic disease, absence of a history of chronic infectious pathology, absence of acute pathology (benign infectious type) intercurrent within the previous 2 weeks. AND \- female, healthy volunteer, non-pregnant, no identified chronic pathology, no history of neoplastic pathology, no history of thromboembolic disease, no history of chronic infectious pathology, no history of acute (benign infectious type) intercurrent pathology within the previous 2 weeks.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * General inclusion criteria : * The patient must have given her free and informed consent and signed the consent * The patient must be a member or beneficiary of a health insurance plan * Only women are included * The patient is at least 18 years old * Inclusion criteria for the target population: * pregnant patient with a complication of the placental vascular pathology type (pre-eclampsia, eclampsia, HELLP syndrome, retroplacental hematoma, fetal death in utero) or venous thromboembolic disease (deep vein thrombosis, pulmonary embolism). OR pregnant woman, without complications (normal pregnancy), absence of identified chronic pathology, absence of a history of neoplastic pathology, absence of a history of thromboembolic disease, absence of a history of chronic infectious pathology, absence of acute pathology (benign infectious type) intercurrent within the previous 2 weeks. OR \- female, healthy volunteer, non-pregnant, no identified chronic pathology, no history of neoplastic pathology, no history of thromboembolic disease, no history of chronic infectious pathology, no history of acute (benign infectious type) intercurrent pathology within the previous 2 weeks. Exclusion Criteria: * General non-inclusion criteria : * The patient is participating in another study * The patient is in an exclusion period determined by a previous study * The patient is under the protection of justice, under guardianship or curatorship * Patient refuses to sign consent * It is impossible to give informed information about * The patient does not read French fluently Criteria for non-inclusion regarding interfering diseases or associated conditions: * The patient is undergoing hormonal ovarian stimulation treatment as part of medically assisted reproduction * The patient is pregnant OR * The patient is breastfeeding OR * The patient has been giving birth for less than 3 months .
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHUNimes
Nîmes, France
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Other studies related to the condition(s) this trial covers.
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