PREGNANCY COMPLICATIONS

This study is for pregnant women with antiphospholipid syndrome (APS) or lupus who are at high risk for complications like miscarriage or early delivery. Researchers are adding a drug called certolizumab to the usual treatment (blood thinners and aspirin) to see if it improves pr…

This study looks at whether giving pregnant people half the usual dose of a steroid (Celestone) can prevent serious health problems in babies born early. About 3,254 participants will be randomly assigned to receive either the standard two doses or just one dose. The goal is to s…

This study looks at whether it is possible and acceptable to start hepatitis C treatment during pregnancy in women who have a history of drug use. About 50 pregnant adults will take the medication glecaprevir-pibrentasvir and be followed for one year. Researchers will measure how…

This study tests whether taking low-dose aspirin for six months after childbirth can help women who had preeclampsia recover their blood vessel health and lower their blood pressure. About 60 new mothers will be randomly assigned to receive aspirin or a placebo. The goal is to se…

This study tests whether using a continuous glucose monitor (CGM) that shows real-time blood sugar on a smartphone app, plus joining a group chat with other pregnant participants, helps keep blood sugar levels healthy during pregnancy. The study enrolls 70 pregnant women at risk …

This study compares an automated insulin delivery system (CamAPS FX) to standard insulin therapy in 305 women with type 1 diabetes who are planning pregnancy or are in early pregnancy. The goal is to see if the automated system helps keep blood sugar in a healthy range and improv…

This study tests whether adding a specially trained doula to standard care helps new mothers with pregnancy-related high blood pressure improve their blood pressure one year after giving birth. About 454 women who had preeclampsia or similar conditions will be randomly assigned t…

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study tests a new method called U-CaVIT, which uses a balloon placed in the uterus to prevent severe bleeding after a C-section in women at high risk. About 70 participants will either get standard care or standard care plus the balloon. The goal is to see if the balloon hel…

This study tests whether providing extra money specifically for healthy groceries during pregnancy can help women avoid gaining too much weight. About 1,440 pregnant women will either receive standard nutrition advice and food assistance referrals, or the same plus up to $3,000 t…

This pilot study tests a simple exercise program designed for high-risk pregnant women who are on bed rest in the hospital. The program includes resistance and strength exercises done in bed, aiming to improve physical health, mood, sleep, and quality of life. About 20 participan…

This study tests two different pain relief methods—propofol sedation and spinal analgesia—during a procedure to turn a breech baby (feet-first) into a head-down position. The goal is to see which method helps more women avoid a C-section and have a safer vaginal birth. About 270 …

This study tests whether a buprenorphine patch can reduce withdrawal symptoms in pregnant women starting treatment for opioid use disorder. About 40 participants will use the patch during the required withdrawal period before switching to standard under-the-tongue buprenorphine. …

This study aims to find a better way to diagnose gestational diabetes in pregnant women who have had bariatric surgery and cannot drink the sugary solution used in the standard test. Researchers will track 84 women using routine blood sugar measures like fasting glucose and HbA1c…

This study uses bedside ultrasound to measure muscle loss, fat changes, and fluid buildup in critically ill pregnant and gynecological patients. Researchers will track 121 women in the ICU to see if these body changes relate to serious outcomes like death, need for a breathing ma…

This study looks at how cells in the placenta die or clean themselves in women with pregnancy complications like preeclampsia or poor fetal growth. Researchers will compare these processes in 50 pregnant women to find new ways to screen for and manage these risks. The goal is to …

This study looks at whether pregnant women with gestational diabetes also have sarcopenia (loss of muscle mass and strength). Researchers will check 200 women for muscle health and follow their pregnancy outcomes. The goal is to understand how common this muscle problem is and if…

This study looks at how things that happen early in life—like pregnancy complications or birth outcomes—can affect the health of mothers and children later on. Researchers are following 24,000 mothers and their babies born at Boston Medical Center. The goal is to learn more about…

This study follows 6,000 pregnant women in rural Pakistan to understand how high environmental temperatures impact pregnancy and birth outcomes. Researchers will monitor heat exposure, collect blood and urine samples, and track the health of mothers and babies for up to a year af…

This study is a worldwide registry that will follow about 10 women with Fabry disease who received the drug pegunigalsidase alfa around the time of pregnancy or while breastfeeding. Researchers will track pregnancy outcomes and infant health for up to one year after birth. The go…

This study looks at how the body processes aspirin in pregnant women who are at risk for preeclampsia, a serious condition involving high blood pressure. Researchers will measure aspirin byproducts and markers of metabolic health in 50 participants. The goal is to better understa…

This study looks back at the pregnancy history of 50 women who were later diagnosed with lupus. The goal is to find out how often pregnancy problems like miscarriage or preterm birth happen before the lupus diagnosis. By understanding these early signs, doctors may be able to spo…

This study is testing two new ultrasound techniques to see if they can better detect fetal growth restriction (FGR), a condition where a baby is smaller than expected. Researchers will compare these scans in 60 pregnant women, some with healthy pregnancies and some with FGR. The …

This study follows pregnant women with a severe hemophilia A gene and their babies after birth. The goal is to learn why some mothers have heavy bleeding after delivery and why some children develop antibodies that make hemophilia treatment less effective. By observing 500 mother…

This study tests a decision support tool called Periviable GOALS for parents facing the threat of giving birth extremely early (between 22 and 25 weeks of pregnancy). The tool provides clear information about outcomes and helps parents clarify their values. About 300 parents will…

This study looks at how the bacteria and natural chemicals in couples' bodies might influence the success of IVF treatment. Researchers will collect samples from 1000 couples to see if these factors are linked to pregnancy, miscarriage, or live birth. The goal is to better unders…