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Rising temperatures threaten pregnancy: new study seeks answers

NCT ID NCT06957769

Knowledge-focused Sponsor: Aga Khan University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 6,000 pregnant women in rural Pakistan to understand how high temperatures impact pregnancy and birth outcomes. Researchers will track heat exposure, collect blood and urine samples, and monitor mothers and babies for up to a year after birth. The goal is to identify biological pathways linking heat stress to complications like low birth weight and preterm birth, helping guide public health strategies in hot climates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 6,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pregnant women residing in peri-urban and rural areas of the three districts of Sindh, i.e., Matiari, Tharparkar and Tando Muhammad Khan

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Single or multiple live pregnancy confirmed through ultrasound * Gestational age less than or equal to 13 weeks and 6 days at enrollment * At least 18 years of age * Permanent resident of the study district and plans to deliver within the district * Willing and able to attend study clinic visits and comply with study procedures throughout pregnancy Exclusion Criteria: • Plan to relocate outside the district for more than 3 months during the study period

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Conditions

The condition(s) this trial relates to.

fetal growth restriction Heat Stress Disorders Infant Death pregnancy disorder Premature Birth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Birth outcome, adverse Heat strain Infant morbidity Infant mortality Low birth weight baby Neonatal mortality Pregnancy complications Preterm birth Small for gestational age (SGA)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Matiari Research and Training Centre

    RECRUITING

    Matiari, Sindh, Pakistan

  • Mithi Study Site Office

    RECRUITING

    Mithi, Sindh, Pakistan

  • Tando Muhammad Khan (TMK) Study Site Office

    RECRUITING

    Tando Muhammad Khan, Sindh, Pakistan

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