PRETERM BIRTH

This study tests whether taking synbiotics (a mix of probiotics and prebiotics) early in pregnancy can help women who have had a preterm birth before. The goal is to see if these supplements can stabilize the vaginal microbiome and reduce the risk of delivering too early. About 4…

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can prolong pregnancy and improve outcomes for pregnant individuals whose water breaks early (before 34 weeks). About 56 participants will be randomly assigned to the new com…

This study looks at whether giving pregnant people half the usual dose of a steroid (Celestone) can prevent serious health problems in babies born early. About 3,254 participants will be randomly assigned to receive either the standard two doses or just one dose. The goal is to s…

This study looks at whether treating pregnant women who have bacteria in their urine but no symptoms can lower the chances of preterm birth, stillbirth, or having a baby that is too small. About 1,134 pregnant women in seven countries will be randomly assigned to receive antibiot…

This study tests whether adding a cervical stitch (cerclage) to vaginal progesterone is better than progesterone alone for preventing preterm birth in pregnant women with a short cervix. About 328 women with a single baby and a cervix shorter than 25 mm will be randomly assigned …

This study tests whether sulfasalazine, a drug used for arthritis, can prevent preterm birth in women who have had one before. About 50 pregnant women will take the drug or be in a control group, and researchers will measure a stress hormone called CRH. The goal is to see if the …

This study tests whether giving caffeine early to premature babies (born before 32 weeks) can prevent acute kidney injury. About 236 newborns will be randomly assigned to receive either caffeine or standard supportive care within hours of birth. The goal is to see if caffeine red…

This UK study follows 90 families of very premature babies (born before 30 weeks) for one year after leaving the hospital. It looks at how the baby's health, especially if they had a serious bowel condition called NEC, affects the family's finances, emotions, and daily life. Pare…

This study looks at how stress and childhood trauma might increase the risk of preterm birth, especially in Black and Hispanic women. Researchers will study mitochondria, the energy centers of cells, to understand how stress gets "under the skin" and affects pregnancy. The goal i…

This study looks at whether giving weekly money to low-income mothers of preterm babies helps them visit the NICU more often. The goal is to see if more visits lead to more breastfeeding and skin-to-skin care, which are good for the baby's health. About 420 mothers will take part…

This study looks at why young adults born very preterm (before 32 weeks) often don't get fitter from aerobic exercise. Researchers think early birth may damage mitochondria, the energy factories in cells, by missing a key fuel switch. They will compare mitochondrial DNA and fitne…

This study follows 6,000 pregnant women in rural Pakistan to understand how high environmental temperatures impact pregnancy and birth outcomes. Researchers will monitor heat exposure, collect blood and urine samples, and track the health of mothers and babies for up to a year af…

This study is following 2,800 pregnant women and their children in Weifang, China, to learn how things like diet, lifestyle, and environment before and during pregnancy affect the health of both mother and child. Researchers will track health issues like diabetes, high blood pres…

This study looks at how showing AI predictions to doctors affects their confidence and accuracy in predicting preterm birth. About 125 doctors will review cases with ultrasound images and see AI results in different formats. The goal is to find which AI presentation helps doctors…

This study aims to find the best time during a routine pregnancy ultrasound to measure the cervix, which helps predict preterm birth risk. About 550 pregnant individuals will be randomly assigned to have their cervical length measured either at the start or end of their anatomy s…

This study looks at whether placing a moderate or late preterm baby directly on the mother's skin right after vaginal birth can reduce stress and improve development. Researchers will compare babies who get immediate skin-to-skin contact with those who are separated briefly. The …

This study looks at whether a special imaging technique (electrical impedance tomography) and lung ultrasound can help doctors predict which premature babies will develop a serious lung condition called bronchopulmonary dysplasia (BPD). The study will include 104 preterm infants …