PRETERM BIRTH

This study looks at what amount of oxygen is safest for babies born a few weeks early (32 to 35 weeks). Doctors will compare giving 60% oxygen versus 30% oxygen right after birth to see which helps babies breathe better and need less breathing support later. Over 1,500 babies in …

The ROOT study tests a personalized nutrition program for pregnant women. By analyzing genes and nutrients, the program creates custom diet plans to reduce risks of preterm birth, preeclampsia, and gestational diabetes. The study will enroll 500 women in North Carolina and compar…

This study tests a personalized support program (PTBCARE+) for pregnant individuals at high risk of delivering early. The program includes stress-reduction tools, a website/app, and extra support during clinic visits. Researchers will compare stress levels and birth outcomes betw…

This study will test whether chewing xylitol-containing gum during pregnancy can reduce the risk of preterm birth and low birthweight. About 6,000 pregnant women in Malawi will be randomly assigned to chew gum with a high or low dose of xylitol, or a placebo gum. The goal is to s…

This study tests a new way to prevent preterm birth by first giving pregnant women a simple risk score. Those at higher risk then get a special ultrasound to check the cervix, followed by proven treatments if needed. Researchers will compare this approach to standard care in 1,00…

This study tests whether a simple, low-cost oral health program—including daily antiseptic mouthwash and brushing instructions—can reduce the number of babies born too early or too small in rural Nepal. About 2,280 pregnant women will take part, with half receiving the extra oral…

This study will see if testing and treating pregnant women for chlamydia and gonorrhea can lower the chance of having a baby too early (preterm birth). About 2,000 women in Botswana will be split into two groups: one gets usual care, the other gets extra STI tests early and late …

This pilot study tests whether giving caffeine to preterm infants (born at 28-34 weeks) who need breathing support can help them leave the hospital sooner. About 62 babies will receive either caffeine or a placebo daily while on respiratory support. The main goal is to see if a l…

This study tests whether a supplement called nicotinamide riboside (a form of vitamin B3) can help mothers of premature or sick babies in the NICU produce more breast milk. Forty mothers will receive either the supplement or a placebo, and researchers will measure milk volume and…

This study will test whether a culturally-based live music intervention can lower stress and reduce the risk of preterm birth in pregnant Black women. Researchers will compare the music group to a control group that only receives verbal support. The goal is to see if music can im…

This study tests whether AI-powered portable ultrasound devices can help frontline health workers detect pregnancy complications early in rural Ethiopia, where access to standard ultrasound is very limited. About 1,059 pregnant women will be split into three groups: two using dif…

This study looks at whether a structured home-based program of sensory and motor activities can improve brain, movement, and thinking skills in babies born early (before 37 weeks). About 28 medically stable preterm infants will take part, with parents guided by therapists. The st…

This study looks at whether bed rest actually helps prevent early birth in pregnant women with a short cervix. About 6,000 women in Denmark will either be prescribed bed rest or not, and researchers will compare how far along they are when they give birth. The goal is to find out…

This study looks at whether expressing breastmilk during pregnancy (from week 28) is safe for women at high risk of preterm birth. It involves 250 pregnant women with conditions like preeclampsia or a history of early delivery. Researchers will measure how long until delivery, ho…