Healthy volunteers

This trial tests an investigational yellow fever vaccine called vYF against the standard YF-VAX vaccine in healthy adults aged 18 to 60. The goal is to see if vYF produces a similar immune response, measured by antibody levels 28 days after a single dose. Researchers will also co…

This trial tests whether booster doses of the MenACYW vaccine, given years after the first shot, keep children and teens protected against meningococcal disease. Researchers will measure antibody levels in the blood before and after the booster to see if the immune system respond…

This early-stage study tests a new vaccine called VXB-241 in healthy adults aged 60-83, with a smaller group of younger adults (18-40) first. The vaccine is designed to protect against two viruses that can cause serious lung infections: RSV and HMPV. Researchers will check how sa…

This Phase 3 study is testing an investigational meningococcal conjugate vaccine (MenACYW) in over 1,600 healthy children and adolescents aged 2 to 17 in China. The vaccine aims to protect against four types of meningococcal bacteria that can cause serious infections like meningi…

This study tests a new booster vaccine called CD40.Pan.CoV in 48 healthy adults in France. The goal is to see if it is safe and can boost the body's defenses against multiple coronavirus variants. Participants receive one injection and are monitored for side effects and immune re…

This study tests a new 21-valent pneumococcal conjugate vaccine (PCV21) in about 1,092 healthy infants and toddlers. The goal is to see if PCV21 is safe and helps the body produce antibodies against pneumococcal bacteria better than the current licensed vaccine. Participants rece…

This study tests a new pentavalent meningococcal vaccine (MenPenta) that aims to protect against five types of meningococcal bacteria (A, B, C, W, Y) in healthy children, toddlers, and infants. Researchers will compare it to existing licensed vaccines and check how well it works …

This study tests a new mRNA vaccine designed to protect against a potential pandemic flu caused by the H5 virus. Healthy adults aged 18 and older will receive either a high, medium, or low dose of the vaccine or a placebo. The goal is to see if the vaccine is safe and triggers a …

This early-stage study tests a new daily pill, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body handles it. Participants will receive either the drug or a placebo, and researchers will monitor…

This study tests an experimental drug called MRT-8102 for the first time in humans. It includes healthy volunteers and people with high inflammation (elevated CRP) who are at risk for heart problems. The goal is to check the drug's safety and find the right dose for future studie…

This early-stage study tests a new drug called CMP-CPS-001 in healthy adults and women who carry a gene for OTC deficiency, a rare liver condition that can cause dangerous ammonia buildup. The main goal is to check the drug's safety and how the body processes it. Participants rec…

This early-stage study tests a new drug called KK4277 in healthy volunteers and people with lupus (SLE or CLE). The main goal is to check safety and how the body processes the drug. It is too early to know if it works, but results will guide future research.

Researchers are collecting blood from about 50 healthy adults aged 22 and older to help develop two new laboratory test kits for syphilis antibodies. Each participant gives one blood sample of roughly 20 to 50 milliliters during a single visit. The serum from these samples is use…

This early-stage trial tests a radioactive imaging agent called RAD301 in 9 people: healthy volunteers and patients with pancreatic, lung, esophageal, cervical, endometrial, or ovarian cancer. The goal is to see how safe it is and how it travels through the body. If it works, it …

This early-stage trial tests a new biologic drug called ABCL635 for moderate-to-severe hot flashes in postmenopausal women. The study first checks safety in healthy volunteers, then measures how well the drug reduces hot flash frequency and severity. About 136 people will take pa…

This study looks at whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder and healthy volunteers make risky or uncertain decisions. Participants will have MRI scans and computer tasks, and some will receive real or sham TMS. The goal is to…

This study collects and analyzes blood, DNA, and tissue samples from 315 adults with pulmonary fibrosis, their relatives, and healthy volunteers. The goal is to learn more about the disease's causes, not to test a new treatment. Researchers hope the findings will guide future the…

This study collects blood, bone marrow, urine, and tissue samples from up to 6,000 people with solid tumors, blood cancers, or non-cancerous blood disorders, as well as from their healthy family members who are stem cell donors. The samples are stored and used in research to bett…

This early-stage study tests a single injection of a new drug, RBD1119, in 32 healthy adults aged 18 to 65. The main goal is to check for side effects and see how the drug moves through the body. Participants are randomly assigned to receive either the drug or a placebo, and no o…

This early-stage trial is testing a new drug called RO7875913 in 40 healthy volunteers to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo. The study aims to find the right dose for future trials, but offers no direct treatme…

This study is an early-stage trial to check the safety of a new drug called RO7763505. It involves 196 participants, first in healthy volunteers and then in people with stable coronary artery disease. The main goal is to see if the drug is safe and how the body processes it, not …

This trial tests whether a single injection of PBP1502, a proposed biosimilar to the arthritis drug Humira, stays in the body the same way as the European and American versions of Humira. Healthy adults aged 18 to 55 receive one of the three injections, and researchers compare dr…

This early-stage trial tests whether a single injection of MWX203 is safe and tolerable in healthy adults aged 18 to 55. Participants must have slightly elevated cholesterol and triglycerides, but not high enough to require medication. The study gives different doses to different…

This study looks at how taking itraconazole (a common antifungal) changes the way the body processes an experimental drug called ABBV-722. It involves 12 healthy adults and focuses on safety and drug levels in the blood. The goal is to gather information, not to treat any disease…

This early-stage study tests the safety and tolerability of a new drug called migaldendranib in 36 healthy volunteers. Participants receive weekly injections, and researchers monitor for side effects and how the drug moves through the body. The study does not aim to treat any dis…

This phase 1 trial is testing whether soticlestat, an experimental drug, has any effect on heart rate or rhythm. Healthy adult volunteers will receive multiple doses of soticlestat, a placebo, or an active control, and their heart activity will be monitored continuously via ECG. …

This study is sequencing the genes of 1665 people aged 45 to 65 to learn how genetic changes relate to health, especially heart disease. Participants provide blood samples and undergo heart tests. The goal is to improve methods for interpreting genetic data and understand how res…

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will use EEG and fMRI to measure brain activity and test a gentle brain stimulation technique called HD-tDCS. The goal is to understand pain processing…

This study looks at how people use their sense of hearing versus physical feeling when they speak. Healthy adults aged 18 to 45 will do speech tasks with altered audio feedback, sometimes with a visual display. Researchers will use a computer model to see if individual difference…

This study aims to establish normal reference ranges for white blood cells and granulocytes using a new device called the Liberty Analyzer WBC System. About 300 healthy adults aged 21 and older will provide blood samples. The results will help doctors interpret future test result…

This trial tests whether a 10-week Basic Body Awareness Therapy (BBAT) program can improve quality of life, reduce pain and work-related stress, and influence eating attitudes in healthy adults aged 25–55 who work at a university. Twenty participants are randomly assigned to eith…

This early-stage study is testing whether adding an enzyme called berahyaluronidase alfa changes how the body processes dupilumab (Dupixent), a drug used for conditions like eczema and asthma. Forty healthy adults will receive a single injection of dupilumab either with or withou…

This early-stage study is testing the safety and tolerability of a drug called midomafetamine in 32 healthy adults aged 18 to 55. Participants receive either a standard or a higher dose and are closely monitored for side effects, heart changes, and how the drug moves through the …

This study looks at whether taking magnesium supplements while doing spinning (indoor cycling) training can improve heart function, reduce inflammation and oxidative stress, and boost aerobic capacity. Healthy men aged 18 to 30 will be assigned to spinning with or without magnesi…

This early-stage study at Stanford University compares ketamine to a placebo (saline) during sedation in 15 healthy adults with major depressive disorder. The goal is to see how these drugs affect brain activity and experiences like dreams or thoughts. Researchers will use EEG to…

This early-stage study tests the safety of a new drug called ABCL575 in 40 healthy adults. Participants receive either a single dose of the drug or a placebo. The goal is to check for side effects and how the body processes the drug, not to treat any disease.

This study follows about 100 healthy adults aged 18 to 29 who have had Epstein-Barr virus (EBV) in the past. Researchers collect blood and saliva samples over 6 to 12 months to see when the virus becomes active again and how the immune system responds. No treatments or vaccines a…

This study looks at how omega-3 fatty acid supplements change the makeup of red blood cells and muscle function in healthy male athletes. Researchers will measure omega-3 levels in blood and use a special device to check muscle responses. The goal is to understand the effects, no…

This study gives 12 healthy volunteers with prior psychedelic experience up to four doses of psilocybin (the active ingredient in magic mushrooms) while scanning their brains with MRI and EEG. Researchers ask participants about their feelings every 100 seconds during scans to lin…

This early-stage trial compares a new drug called IBI3027 to the approved medication Dupixent. It involves 180 healthy Chinese men who receive a single injection of either drug. The goal is to see if IBI3027 is absorbed and cleared from the body similarly to Dupixent, and to chec…

This study looks at whether storing blood samples (frozen or at different temperatures) changes the accuracy of a vitamin D test called the ALPCO 25(OH) Vitamin D CLIA Kit. Researchers will compare results from fresh blood with those from stored samples in 80 healthy adults. The …

This early-stage study tests VSA012, a drug that targets the complement system (part of the immune system), in 40 healthy volunteers. The main goal is to check safety and how the drug moves through the body after a single dose. It is a first step before testing in patients with c…

This early-stage study is testing a new drug, SL-325, in 72 healthy volunteers to see if it is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor for side effects. This study does not aim to treat any disease but to gath…

This study uses a special camera (OCT) to take detailed pictures of the eyes of 20 healthy adults. The goal is to improve the camera's software so it can better detect eye diseases in the future. Participants have no eye problems and will not receive any treatment.

This early study tests whether sirolimus, an FDA-approved drug, can improve blood flow to the brain in healthy adults with a genetic risk for Alzheimer's disease. Researchers will use MRI scans to measure changes after 4 weeks of daily low-dose sirolimus. The study also explores …

This study is testing a special imaging agent called [13C]pyruvate to see how it behaves in healthy organs and tissues during MRI scans. Fifty healthy volunteers aged 18 to 80 will receive an injection of the agent, and researchers will measure image quality. The goal is to impro…

This study was designed to measure DNA damage in cells from the mouth of smokers, vapers, and people who do not use tobacco or nicotine products. The goal was to find which types of damage might be more likely to cause oral cancer. However, the study was withdrawn before any part…

This study is creating a large community registry and biorepository with 50,000 adults from Cabarrus County and Kannapolis. Participants provide health information and biological samples to help researchers better understand chronic diseases and improve medicine. It is an observa…

This early-stage study tests the safety of a new drug called JADE101 in 32 healthy adults aged 18 to 55. Participants receive either a single dose of JADE101 or a placebo by injection under the skin. The goal is to see how the body handles the drug and whether it causes any side …

This study was designed to test a new breath-activated inhaler (EDDIS) in healthy adults. Participants would have inhaled a tiny amount of radioactive liquid to see how well the device delivers medication to the lungs. The study was withdrawn before any volunteers were enrolled, …

This study was designed to see how various drugs, including stimulants, cannabinoids, and opioids, affect mood, pain, and thinking in healthy adults aged 18-55. Participants would have taken blinded oral medications and reported their experiences. However, the study was withdrawn…

This Phase 1 trial is the first time ORKA-002 is being tested in humans. It involves 24 healthy adults to check the drug's safety, tolerability, and how the body processes it. Participants receive a single injection of either ORKA-002 or a placebo. The study is not designed to tr…