HEALTHY VOLUNTEERS

This early-stage study tests a new vaccine (VXB-241) designed to protect against two respiratory viruses: RSV and HMPV. About 144 healthy adults, including those aged 60-83, will receive one dose of the vaccine at different strengths to check its safety and how well it boosts the…

This study tests a new vaccine designed to protect against four types of meningococcal bacteria that can cause serious infections like meningitis. Around 1,600 healthy children and teens aged 2 to 17 in China will receive either the new vaccine or a currently approved one. Resear…

This study is testing a new vaccine that aims to protect against five types of meningococcal bacteria (A, B, C, W, Y) that can cause serious infections like meningitis. The trial includes healthy children aged 2 to 9 years, toddlers 12 to 15 months, and infants 2 months old. Rese…

This study tests a new 21-valent pneumococcal vaccine (PCV21) in about 1,092 healthy infants and toddlers to see if it is safe and helps their bodies build defenses against pneumococcal bacteria. The vaccine is given alongside routine childhood shots at ages 2, 4, and 11-15 month…

This early-stage trial tests a new booster vaccine called CD40.Pan.CoV in 48 healthy adults in France. The goal is to see if it is safe and can boost the body's defenses against many types of coronaviruses. Participants receive one shot and are monitored for side effects and immu…

This study tests a new mRNA vaccine designed to protect against a potential pandemic flu (H5N1). About 720 healthy adults aged 18 and older will receive either a high, medium, or low dose of the vaccine or a placebo. The goal is to see if the vaccine is safe and triggers a strong…

This early-stage study tests a new drug called KK4277 in healthy volunteers and people with lupus (SLE or CLE). The main goal is to check if the drug is safe and tolerable. Researchers will also measure how the drug moves through the body. The study does not aim to cure lupus, bu…

This early-stage study tests whether black raspberry confections can help prevent oral cancer in 67 healthy volunteers. Researchers will measure how the body absorbs berry compounds and how they affect genes linked to cancer and inflammation. Participants follow a berry-restricte…

This early-stage study tests the safety of a new drug called ORKA-002 in 24 healthy adults aged 18 to 65. Participants receive a single dose and are monitored for side effects and how the drug moves through the body. The goal is to gather initial safety data, not to treat any dis…

This early-phase study tests the safety of a new drug, budoprutug, in 38 healthy adults aged 18-60. Participants receive either the drug or a placebo by injection or IV. The goal is to check for side effects and how the drug moves through the body, not to treat any disease.

This study involves 50 healthy volunteers aged 18-80 to learn how a substance called [13C]pyruvate behaves in the body during an MRI scan. The goal is to improve image quality and understand how different organs use energy normally. Participants will receive the substance through…

This study checks if a new drug called IBI3027 works like the approved drug Dupixent in healthy Chinese men. 180 volunteers get one shot of either drug and are monitored for 56 days. The goal is to compare drug levels and safety, not to treat any disease.

This study follows about 100 healthy adults aged 18 to 29 who have had Epstein-Barr virus (EBV) in the past. Researchers collect blood and saliva samples over 6 to 12 months to see when the virus becomes active again and how the immune system responds. No treatment or vaccine is …

This study will test a new version of an eye imaging device (OCT) in 20 healthy adults. The goal is to improve image quality and speed so that eye diseases can be detected earlier. No treatment is given; participants simply undergo imaging to help refine the technology.

This study looks at how the natural bacteria in your gut might change how well the cholesterol-lowering drug rosuvastatin works. Researchers will track changes in gut bacteria and cholesterol levels in about 100 healthy adults over 16 weeks. The goal is to understand why some peo…

This early-stage study at Stanford University compares ketamine to a saltwater placebo during sedation in 15 healthy volunteers with major depressive disorder. The goal is to see if ketamine changes the experience of sedation and affects mood or well-being. Participants will be m…

This early-stage study tests JADE101 in 32 healthy adults to see if it is safe and how the body handles it. Participants receive a single shot of the drug or a placebo. The goal is to gather safety information, not to treat any disease.

This study collects blood, lung tissue, and other samples from people with pulmonary fibrosis, their relatives, and healthy volunteers. Researchers analyze these samples to learn what causes the disease and how it progresses. No treatments or medications are tested. The goal is t…

This study was designed to see how different drugs and drug combinations change mood, pain tolerance, and thinking skills in healthy adults aged 18 to 55. Researchers planned to measure how much of a drug people would take and how much they would pay for it. The study was withdra…

This study looks at the genes of about 1,665 people aged 45 to 65 to learn how gene changes relate to heart disease and other health conditions. Participants donate blood, have heart tests, and may learn about important gene findings. The goal is to improve our understanding of g…

This study checks if a new single pill containing three diabetes medicines (gemigliptin, dapagliflozin, metformin) works the same in the body as taking the three drugs separately. It involves 58 healthy adults aged 19 to 50 who will receive both treatments in random order under f…

This study was designed to test a new breath-activated inhaler (EDDIS) in healthy adults. Researchers planned to use a tiny amount of radioactive tracer to see where the inhaled mist lands in the lungs and check for side effects. The study was withdrawn before any volunteers were…

This early-stage study tests the safety of a new drug, RBD1119, in 32 healthy adults aged 18 to 65. Participants receive a single injection of either the drug or a placebo, and researchers monitor for side effects and how the drug moves through the body. The goal is to gather ini…

This study explores whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder make risky or uncertain decisions. About 60 adults (some with opioid use disorder, some healthy) will receive both real and fake TMS while having brain scans. The go…

This study was designed to measure DNA damage in cells from the mouth of smokers, vapers, and people who never used tobacco or nicotine. The goal was to see which types of damage might be more likely to cause oral cancer. However, the study was withdrawn before any participants w…

This study is creating a large community registry and biorepository with 50,000 adults from Cabarrus County and Kannapolis. Participants provide health information and samples to help researchers better understand chronic diseases and improve future medicine. The goal is to build…

This early-stage study is testing a new drug called SL-325 in 72 healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and no direct treatment benefit is expected.

This study looks at how psilocybin (the active ingredient in magic mushrooms) changes brain activity and body responses in healthy volunteers. Twelve people with past psychedelic experience will take four doses of psilocybin and have MRI and EEG scans. The goal is to understand t…

This study tests whether a single dose of balinatunfib affects the heart's electrical activity in 48 healthy adults aged 18 to 55. Researchers measure changes in heart rhythm over time using an ECG. The goal is to ensure the drug is safe for the heart before moving to larger tria…

This early-stage study looks at whether sirolimus, an FDA-approved drug, can increase blood flow to the brain in healthy adults aged 45-65. Some participants have a genetic risk for Alzheimer's (APOE4 gene), while others do not. The goal is to understand how the drug affects brai…

This early-stage study tests a new drug called ABBV-277 in 32 healthy adults for the first time. The main goal is to check its safety and how the body processes it. Participants receive a single dose and are monitored closely. This study does not aim to treat any disease.

This study looks at how psilocybin, the active ingredient in magic mushrooms, changes brain function and thinking in 15 healthy adults. Participants receive psilocybin in a controlled setting while their brain activity is measured with EEG and TMS. The goal is to understand how p…